Evaluation Of Factor Va From The Venom Of The Australian Brown Snake As A Topical And Systemic Anti-bleeding Agent
Funder
National Health and Medical Research Council
Funding Amount
$113,742.00
Summary
Anti-bleeding agents are important pharmaceuticals for use in truama, surgery and several medical conditions to reduce blood loss and the need for blood transfusion. Some Australian snakes contain in their venom a powerful blood clotting agent. This agent mimics the human clotting machinery. In this project, we plan to test purified components of snake venom for an ability to clot human blood. We will undertake laboratory test-tube experiments as well as using an animal model after ethical appro ....Anti-bleeding agents are important pharmaceuticals for use in truama, surgery and several medical conditions to reduce blood loss and the need for blood transfusion. Some Australian snakes contain in their venom a powerful blood clotting agent. This agent mimics the human clotting machinery. In this project, we plan to test purified components of snake venom for an ability to clot human blood. We will undertake laboratory test-tube experiments as well as using an animal model after ethical approval. This project seeks to capture some of the genetic blueprint of an Australian snake, for human benefit by developing a new therapeutic agent based on a venom component. If the experiments are successful, the next stage will be further testing of efficacy and toxicity before seeking approval for clinical trials. The research is supported by the Australian pharmaceutical company QRx Pharma Pty Ltd who will work with Uniquest Pty Ltd to protect intellectual property generated in the project.Read moreRead less
Development Of Miniaturized Microwave Catheter Antennas And Monitoring Systems For Transcatheter Ablation For The Cure O
Funder
National Health and Medical Research Council
Funding Amount
$161,500.00
Summary
The development of microwave cardiac ablation system is crucial to the development towards a permanent cure for cardiac arrhythmias. Cardiac ablation using microwave energy can overcome the limitations of current ablative energy such as laser and RF ablation. Based on the combined knowledge and experience of UTS and Westmead hospital researchers, the proposed research is to develop a working prototype of cardiac ablation system using microwave energy based on our patent. The ultimate aim would b ....The development of microwave cardiac ablation system is crucial to the development towards a permanent cure for cardiac arrhythmias. Cardiac ablation using microwave energy can overcome the limitations of current ablative energy such as laser and RF ablation. Based on the combined knowledge and experience of UTS and Westmead hospital researchers, the proposed research is to develop a working prototype of cardiac ablation system using microwave energy based on our patent. The ultimate aim would be to attract interested industry parties to take up for full production and commercialisation.Read moreRead less
Development Of Recombinant RsolCD39-PSGL As A Novel Therapeutic With Anti-thrombotic And Anti-inflammatory Effects
Funder
National Health and Medical Research Council
Funding Amount
$186,367.00
Summary
Heart disease and stroke are due to a narrowing of arteries followed by occlusion, due a combination of clot formation initiated by platelet clumping, and inflammation surrounding the vessel wall. The currently available drugs are often limited by the adverse reaction of bleeding. We will investigate the efficiency of a new drug to prevent clot formation and inflammation.