A model of the mind which explains the role of emotions in normal cognition and affective disorder. Depression is recognised as one of the most burdensome diseases in Australia. Though we of course make no claims, as philosophers, to cure depression our contribution is to engage philosophy productively with a vital national area of empirical research. The other area of national benefit is to consolidate Australia's developing reputation as a site for the involvement of philosophy in interdiscipl ....A model of the mind which explains the role of emotions in normal cognition and affective disorder. Depression is recognised as one of the most burdensome diseases in Australia. Though we of course make no claims, as philosophers, to cure depression our contribution is to engage philosophy productively with a vital national area of empirical research. The other area of national benefit is to consolidate Australia's developing reputation as a site for the involvement of philosophy in interdisciplinary projects which link the humanities to the sciences. Furthermore, with the project's anchoring in the humanities, there is hope that a focus on, and increased understanding of, depression will have flow-on effects in the Australian community that will help ease the stigmatisation that is still felt by many of its sufferers.Read moreRead less
Determinants of Audio-Visual effects in degraded and non-degraded speech. Seeing a speaker's face can affect the perception of their speech in a number of ways. This project proposes a detailed comparison of factors that affect Audio-Visual (AV) facilitation of degraded speech detection and identification. Detection-based tasks should be more sensitive to signal based correlations whereas identification-based effects more sensitive to complementary information. The significance of the current pr ....Determinants of Audio-Visual effects in degraded and non-degraded speech. Seeing a speaker's face can affect the perception of their speech in a number of ways. This project proposes a detailed comparison of factors that affect Audio-Visual (AV) facilitation of degraded speech detection and identification. Detection-based tasks should be more sensitive to signal based correlations whereas identification-based effects more sensitive to complementary information. The significance of the current proposal is that it offers both a strategy and a connected series of experiments for determining key behavioural constraints on AV speech integration. Understanding AV interactions will build links between neurophysiological processes and coherent perception and have important implications for AV application.Read moreRead less
THE EFFECT OF STRESS AND ENVIRONMENTAL ENRICHMENT ON DISEASE PROGRESSION IN MESIAL TEMPORAL LOBE EPILEPSY
Funder
National Health and Medical Research Council
Funding Amount
$578,201.00
Summary
Mesial temporal lobe epilepsy, the most common form of drug-resistant epilepsy in adults, is a progressive neurodegenerative condition for which there is currently no effective disease modifying treatment. This proposal will explore whether co-morbid stress accelerates disease progression in MTLE, and whether targeting stress pathways by medical and environmental manipulations can mitigate against this.
C-Jun N-terminal Kinase Actions In The Response To Stress
Funder
National Health and Medical Research Council
Funding Amount
$480,127.00
Summary
All cells in our body sense and respond to stressful changes in our environment. We are focused on enzymes called JNKs that relay this information, and so form part of the key response pathways. JNKs are now being evaluated as new drug targets for the treatment of diseases including diabetes and stroke, but we know very little about how JNKs work in stressed cells. We will define new partners for the JNKs and in so doing reveal new information on the stress-activated events they regulate.
Conscious states in conscious creatures: A philosophical framework for the science of consciousness. Consciousness is a major research focus world-wide. Though Australia is well represented in the field, comparatively few Australian researchers have ventured into the philosophy of consciousness science. This project will consolidate Australian research scholarship in this foundational area of philosophy, and will also contribute to the emergence of an experimental science of consciousness. An un ....Conscious states in conscious creatures: A philosophical framework for the science of consciousness. Consciousness is a major research focus world-wide. Though Australia is well represented in the field, comparatively few Australian researchers have ventured into the philosophy of consciousness science. This project will consolidate Australian research scholarship in this foundational area of philosophy, and will also contribute to the emergence of an experimental science of consciousness. An understanding of consciousness is important for understanding a number of national health concerns such as schizophrenia, coma and epilepsy. This is a project in the philosophical foundations of consciousness science, but it has some potential to inform new research and therapeutic strategies in these areas.Read moreRead less
Consciousness in the predictive mind. The project aims to provide a unified approach to the nature of consciousness. Neuroscience and philosophy are still unable to explain how the brain gives rise to our conscious experience. Competing theories of consciousness are piecemeal, difficult to test and compare, and mostly formulated without much regard to a general theory of brain function. This project takes a different approach: it front-loads a new and influential general theory of brain function ....Consciousness in the predictive mind. The project aims to provide a unified approach to the nature of consciousness. Neuroscience and philosophy are still unable to explain how the brain gives rise to our conscious experience. Competing theories of consciousness are piecemeal, difficult to test and compare, and mostly formulated without much regard to a general theory of brain function. This project takes a different approach: it front-loads a new and influential general theory of brain function, and aims to use this theory to determine which theories of consciousness can be defended and which rejected. The anticipated outcome is a unified scientific and theoretical approach to consciousness, achieving a deeper and more integrated understanding of a major field of contemporary neuroscience and philosophy research.Read moreRead less
Measuring the Mind: A Framework for Building a Consciousness Meter . This project aims to develop a new framework for measuring consciousness. The lack of well-validated measures of consciousness is at the root of a methodological crisis in the science of consciousness. Drawing on work in the philosophy of science and mind, the project plans to investigate whether consciousness can be measured in the way that other natural properties can be measured. The results of this project may inform guidel ....Measuring the Mind: A Framework for Building a Consciousness Meter . This project aims to develop a new framework for measuring consciousness. The lack of well-validated measures of consciousness is at the root of a methodological crisis in the science of consciousness. Drawing on work in the philosophy of science and mind, the project plans to investigate whether consciousness can be measured in the way that other natural properties can be measured. The results of this project may inform guidelines for the objective assessment of consciousness in the context of post-coma brain injury, anaesthesia, epileptic absence seizures, infancy and non-human animals.Read moreRead less
I am an academic endocrinologist and clinician. I lead a large research program that investigates the links between hormones and diseases of ageing in women. Thus my research program addresses the contribution of changes in adrenal and ovarian steroids in
The Efficacy Of N-acetyl Cysteine As An Adjunctive Treatment For First Episode Psychosis
Funder
National Health and Medical Research Council
Funding Amount
$2,143,069.00
Summary
First episode psychosis may foreshadow devastating, chronic illness. Psychosis follows a staged, progressive pathway. There is evidence to suggest illness progression can be diminished and perhaps even averted if appropriate treatments are given at the early stages of illness. This project will test if N-acetycysteine (NAC) administered to young people who have experienced a first episode of psychosis can help prevent this early psychotic experience from developing into a chronic disorder.