Humane Chemical Methods for Population Management of Highly Valued Large Mammals. In many countries valued wild and feral animals are nonetheless too numerous. Their population numbers must be controlled through fertility. Examples are koalas in Australia, deer and seals in North America, cattle in India and dogs in Thailand. We aim to develop benign implants for castration based upon the gonadotrophin releasing hormone (GnRH). These implants are easily administered. The outcomes will be to ....Humane Chemical Methods for Population Management of Highly Valued Large Mammals. In many countries valued wild and feral animals are nonetheless too numerous. Their population numbers must be controlled through fertility. Examples are koalas in Australia, deer and seals in North America, cattle in India and dogs in Thailand. We aim to develop benign implants for castration based upon the gonadotrophin releasing hormone (GnRH). These implants are easily administered. The outcomes will be to protect Australia's ?green? image , worldwide market opportunities for the Australian companies involved in this application and valuable intellectual property for Macquarie. The methodology will in time allow us to apply it to the treatment of cancer.Read moreRead less
Genomic Basis of Resistance to Poisoning by Sodium Fluoroacetate (Compound 1080) in Australian Wildlife. In Australia agricultural conservation activities worth billions of dollars are protected by using sodium fluoroacetate (1080) against pest animals. Target species are Australian rabbits and foxes and New Zealand brushtail possums. Prolonged use of biocontrol agents causes genetic resistance. This occurs naturally in Western Australia in native animals living in areas with high levels of 1080 ....Genomic Basis of Resistance to Poisoning by Sodium Fluoroacetate (Compound 1080) in Australian Wildlife. In Australia agricultural conservation activities worth billions of dollars are protected by using sodium fluoroacetate (1080) against pest animals. Target species are Australian rabbits and foxes and New Zealand brushtail possums. Prolonged use of biocontrol agents causes genetic resistance. This occurs naturally in Western Australia in native animals living in areas with high levels of 1080 in native plants. As part of the Kangaroo Genome project our aim is to discover the genomic basis of this resistance. The outcomes will be improved ability to manage pest animal populations and understanding of the evolution of plant-animal interactions.Read moreRead less
Are neurobehavioural and neuromotor impairments associated with FMR1 gene expansion? The gene that causes Fragile X syndrome is found at the end of the X chromosome and is present in all humans. In many cases there is a small to medium change in this gene that may cause psychological and motor difficulties in later adulthood. The core aim of this project is to identify early age-related changes that would indicate later neurological decline.
Discovery and characterization of new classes of small regulatory RNAs in mammals. The project will reaffirm and enhance Australian leadership in the most rapidly developing area of molecular biological and genetic research, by the application of ultra high-throughput sequencing technologies to discovery of regulatory RNAs, thereby to identify the characteristics of important regulatory pathways that underpin mammalian development, brain function and species diversity. The results of this resear ....Discovery and characterization of new classes of small regulatory RNAs in mammals. The project will reaffirm and enhance Australian leadership in the most rapidly developing area of molecular biological and genetic research, by the application of ultra high-throughput sequencing technologies to discovery of regulatory RNAs, thereby to identify the characteristics of important regulatory pathways that underpin mammalian development, brain function and species diversity. The results of this research will have wide implications and applications in biotechnology, genetic engineering, animal breeding, medical science and advanced informatics.Read moreRead less
The major histocompatibility complex and scent-mediated mate choice in a Procellariiform, Gould's petrel. In Australia, there are 25 species of Procellariiformes listed as threatened or endangered under the Environment Protection and Biodiversity Conservation Act 1999. Formulating comprehensive conservation plans for endangered species requires a good understanding of the species' breeding biology yet virtually nothing is known about the mechanisms involved in mate choice in the procellariiforms ....The major histocompatibility complex and scent-mediated mate choice in a Procellariiform, Gould's petrel. In Australia, there are 25 species of Procellariiformes listed as threatened or endangered under the Environment Protection and Biodiversity Conservation Act 1999. Formulating comprehensive conservation plans for endangered species requires a good understanding of the species' breeding biology yet virtually nothing is known about the mechanisms involved in mate choice in the procellariiforms. A better understanding of the traits these long-lived birds use when choosing their lifelong breeding partner could greatly benefit conservation strategies designed to protect them. This could be particularly beneficial where translocation is an option because birds being translocated could be assessed for compatibility prior to translocation.Read moreRead less
Identification of genetic polymorphisms of synaptically expressed genes that contribute to variation in normal brain function. This project focuses on understanding brain functions. Brain and mind disorders are by far the largest contributors to the burden of disability, far exceeding any other disorder. This research will contribute to knowledge through addressing the national research priority promoting and maintaining good health. The research outcomes will form the scientific knowledge base ....Identification of genetic polymorphisms of synaptically expressed genes that contribute to variation in normal brain function. This project focuses on understanding brain functions. Brain and mind disorders are by far the largest contributors to the burden of disability, far exceeding any other disorder. This research will contribute to knowledge through addressing the national research priority promoting and maintaining good health. The research outcomes will form the scientific knowledge base essential for the translation of the project into public benefit through their application in development of new testing paradigms for a range of brain and mind disorders. Read moreRead less
Northern connections-movement of birds between Australia and its near northern neighbours. This project will better enable Australia to meet its international treaty obligations on migratory birds and provide much needed data on patterns of migratory connectivity in northern Australia. These data are critical for the conservation and management of bird species that spend part of their life-cycle outside Australia. The outputs of the project will be used to assist decision makers with policy and ....Northern connections-movement of birds between Australia and its near northern neighbours. This project will better enable Australia to meet its international treaty obligations on migratory birds and provide much needed data on patterns of migratory connectivity in northern Australia. These data are critical for the conservation and management of bird species that spend part of their life-cycle outside Australia. The outputs of the project will be used to assist decision makers with policy and management decisions relevant to (1) targeted surveillance for exotic and emergent diseases of relevance to Australia and (2) the conservation and management of bird populations in Northern Australia.Read moreRead less
Rapid evolution via genetic novelty in an invasive social insect. This project aims to determine how introduced Asian honey bee populations in Australia and the Pacific managed to overcome severe genetic bottlenecks to become invasive pests. The project will use advanced molecular techniques to understand rapid evolution at a focal gene that determines fitness in these populations, and to see evolution in action across the genome using a twelve-year timeline of samples. The outcome will be an en ....Rapid evolution via genetic novelty in an invasive social insect. This project aims to determine how introduced Asian honey bee populations in Australia and the Pacific managed to overcome severe genetic bottlenecks to become invasive pests. The project will use advanced molecular techniques to understand rapid evolution at a focal gene that determines fitness in these populations, and to see evolution in action across the genome using a twelve-year timeline of samples. The outcome will be an enhanced capacity to manage new outbreaks of invasive social insects of all kinds via a better understanding of how invasions establish and spread. This should provide significant benefits in the form of protecting Australian agriculture and pollination services from social insect pests.Read moreRead less
The functional genomics of locust migratory behaviour. Unravelling the molecular genetic basis of locust migratory behaviour will place Australia at the forefront of international biological research and simultaneously contribute to the development of new and safer ways to manage these notorious agricultural pests. We will use genomics and gene expression analyses to identify the suite of genes involved in the behavioural changes that catalyse locust swarm formation and migration. This collabor ....The functional genomics of locust migratory behaviour. Unravelling the molecular genetic basis of locust migratory behaviour will place Australia at the forefront of international biological research and simultaneously contribute to the development of new and safer ways to manage these notorious agricultural pests. We will use genomics and gene expression analyses to identify the suite of genes involved in the behavioural changes that catalyse locust swarm formation and migration. This collaborative study will enhance international relations with China, foster the development of gene-focused locust control strategies, and provide an exemplar study of an important and complex problem faced by Australia and international community.Read moreRead less
Australian plague locust population genetics and migratory behaviour. The project will allow improved monitoring and forecasting of locusts in Australia and thereby help prevent locust outbreaks. Benefits will arise directly through greater effectiveness in reducing locust damage to crops, and indirectly to Australian rural industry generally through the economic benefits of reduced losses and locust control costs. Environmental and social benefits will also arise from reduced, better targeted u ....Australian plague locust population genetics and migratory behaviour. The project will allow improved monitoring and forecasting of locusts in Australia and thereby help prevent locust outbreaks. Benefits will arise directly through greater effectiveness in reducing locust damage to crops, and indirectly to Australian rural industry generally through the economic benefits of reduced losses and locust control costs. Environmental and social benefits will also arise from reduced, better targeted use of chemical insecticides. This in turn can produce secondary economic benefits, e.g. through enhanced growth and profitability of the organic beef industry within the main locust-outbreak area. Read moreRead less