Modifying The Trajectory Of Insidious Late Life Cognitive Decline Using Computerised Cognitive Training
Funder
National Health and Medical Research Council
Funding Amount
$743,152.00
Summary
Supervised, group-based computerised cognitive training (CCT) is a safe and effective intervention to maintain cognition in healthy older adults. This project will examine the extent to which CCT can attenuate or even reverse the rate of decline in older people with previously documented cognitive decline, as well as strategies to maintain CCT effects in the long term.
Moving Behavioural Neuroscience & Neuroeconomics Into Dementia Prevention: Spatial Tracking And Economic Decision-making As New Sensitive Measures Of Daily Function
Funder
National Health and Medical Research Council
Funding Amount
$595,588.00
Summary
This project will aim to develop new measures for clinical trials by learning the relationship between older people's movements around the house, ability to make decisions about their health and finance and their cognitive performance. These instruments may aid future trials of drugs and other interventions for preventing dementia by indicating how basic behavioural patterns respond to interventions.
Modifiable Risks And Interventions For Cognitive Decline, Depression And Dementia In Older People
Funder
National Health and Medical Research Council
Funding Amount
$430,055.00
Summary
This research proposal will explore the modifiable risk factors for cognitive decline (ie. changes in memory and thinking functions) in older people. It will examine the pertinence of critical contributors to glial-neuronal networks including depression, cardiovascular disease, sleep-wake systems, mental and physical exercise, inflammatory processes and diet, as well as test interventions that target these risk factors. It will use sophisticated brain scanning methods to examine which factors pr ....This research proposal will explore the modifiable risk factors for cognitive decline (ie. changes in memory and thinking functions) in older people. It will examine the pertinence of critical contributors to glial-neuronal networks including depression, cardiovascular disease, sleep-wake systems, mental and physical exercise, inflammatory processes and diet, as well as test interventions that target these risk factors. It will use sophisticated brain scanning methods to examine which factors promote neuroplasticity.Read moreRead less
A Selective Prevention Trial Using Novel Pharmacotherapies In An Older Age Cohort At Risk For Depression
Funder
National Health and Medical Research Council
Funding Amount
$975,259.00
Summary
The study will examine whether omega-3 fatty acids or antidepressants prevent the onset of depression in a group of older community participants who have previously been identified as being "at risk" of depression. The study will incorporate sophisticated brain scanning methods, as well as tests of brain functioning to determine acute brain changes, reduction in cognitive decline and prevention of depression over a one-year period.
Benefits Of Home-based Multidisciplinary Rehabilitation In Non Small Cell Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$581,039.00
Summary
Lung cancer is the third leading cause of death in Australia. People with lung cancer experience a complex mix of symptoms that can provoke significant distress and impair physical function. This study aims to develop and test a home based exercise and self-management support program to increase function and physical activity levels, reduce levels of depression and improve quality of life of people with lung cancer.
The Impact Of Circadian Disturbances On Sleep Quality, Cognition And Psychiatric Symptoms In Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$496,340.00
Summary
There is an increasing awareness that neurodegenerative diseases are associated with disturbances in sleep. Our group have recognised that patterns of sleep disturbance in these patients are also related to problems with memory and mood. The proposed study will be the first of its kind to explore whether disruptions in the circadian system represent a common mechanism underlying these comorbid disease features. Understanding this pathology will hopefully lead to the development of new therapies.
The development of predictive brain function in preschool children. This project aims to track developmental changes in brain activity and connectivity in typically developing three-to-six year-old children. The preschool years are a time of huge change in children's cognitive abilities, but little is known of the corresponding changes in brain function. This work will use child-optimised magnetoencephalography to test the hypothesis that early cognitive development is characterised by refinemen ....The development of predictive brain function in preschool children. This project aims to track developmental changes in brain activity and connectivity in typically developing three-to-six year-old children. The preschool years are a time of huge change in children's cognitive abilities, but little is known of the corresponding changes in brain function. This work will use child-optimised magnetoencephalography to test the hypothesis that early cognitive development is characterised by refinement of the brain's innate ability to generate predictions about the sensory environment. The resulting insights could improve understanding of neurodevelopmental disorders such as autism.Read moreRead less
Dynamics of word recognition: new insight from the reach-to-touch paradigm. This project will introduce a new behavioural reach-to-touch paradigm for studying basic cognitive processes such as word recognition. The advantage of this paradigm is that it is able to measure cognitive processes moment-by-moment as they unfold over time. This will provide new insights into the temporal dynamics of basic cognitive processing.
Risky Futures: Toward a Computational Process Model of Risky Inter-Temporal Choice. A lot is known about people’s preferences. People like their rewards now. Most would prefer $10 today than $20 in one month. Risk is also unattractive; a certain $10 is more attractive than a 50 per cent chance of receiving $25. Surprisingly, much less is known about the interaction between delay and risk. That is, relatively little is known about whether people prefer $10 now, or a 50 per cent chance of $50 in ....Risky Futures: Toward a Computational Process Model of Risky Inter-Temporal Choice. A lot is known about people’s preferences. People like their rewards now. Most would prefer $10 today than $20 in one month. Risk is also unattractive; a certain $10 is more attractive than a 50 per cent chance of receiving $25. Surprisingly, much less is known about the interaction between delay and risk. That is, relatively little is known about whether people prefer $10 now, or a 50 per cent chance of $50 in one month. This project will use a combination of experiments and cognitive modelling to examine all three types of choice. The outcome will be a novel computational model that will elucidate the complex interaction between delay and risk, thereby answering an enduring question in the literature: are risk and delay psychologically equivalent?Read moreRead less
Cross-comparison, Validation And Performance Of Computerised Neuropsychological Assessment Devices In The Evaluation Of Mild Cognitive Impairment And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$700,482.00
Summary
With an ageing population and associated increase in dementia there will be increased demand for neuropsychological assessment, with insufficient trained personnel and resources to meet this demand. Computerised tests offer excellent opportunities for large scale implementation of cognitive screening and monitoring of older adults. This is the first study to systematically evaluate and compare several popular computerised neuropsychological assessment devices in elders with and without dementia.