Improving neuronal cell function with cell permeable copper complexes. Metal-based drugs offer an exciting new approach to treatment of neurodegeneration. However, little is known about how cells metabolise these drugs and this information is critical for further drug development. This project will determine how metal-based drugs are metabolised by neuronal cells and how this may result in therapeutic benefit.
Language processing in children with high functioning autism: Evidence from eye tracking. The language abilities in people with autism predict their response to intervention and their cognitive outcome. Young children with autism with poor language abilities are severely disadvantaged. Yet we understand little about what impedes their language development and their interpretation of what others say. The research findings will make a significant contribution by enriching our understanding of why ....Language processing in children with high functioning autism: Evidence from eye tracking. The language abilities in people with autism predict their response to intervention and their cognitive outcome. Young children with autism with poor language abilities are severely disadvantaged. Yet we understand little about what impedes their language development and their interpretation of what others say. The research findings will make a significant contribution by enriching our understanding of why and how comprehension may go astray, as well as helping us to identify subgroups within the autism population.Read moreRead less
Engineering functional nerves using microtailored culture systems. The aim of this work is to develop new culture systems for developing and growing nerves outside of the body. The project will generate knowledge and engineering technology for production of neural implants suitable for medical applications. The availability of engineered nerve grafts to repair neural injuries will improve patient health outcomes.
The impact of environmental toxicants on the fertility of female animals. This study aims to address a problem of national significance; determining the impact of commonly used environmental toxicants (pesticides) on the fertility and health of female animals, both agricultural and native. This project expects to generate new knowledge in the fields of ovarian biology, female fertility and toxicology by using a combination of mouse and marsupial animal models. The expected outcomes include the e ....The impact of environmental toxicants on the fertility of female animals. This study aims to address a problem of national significance; determining the impact of commonly used environmental toxicants (pesticides) on the fertility and health of female animals, both agricultural and native. This project expects to generate new knowledge in the fields of ovarian biology, female fertility and toxicology by using a combination of mouse and marsupial animal models. The expected outcomes include the establishment of interdisciplinary collaborations and provision of world-class training for staff and students in the field of reproductive biology. This project should provide significant benefits, such as improved chemical management in livestock production and the development of marsupial conservation action plans.Read moreRead less
Adaptive Evolution of BRCA1 in Ancestral Mammals. This project investigates adaptive evolution of BRCA1 in the early radiation of mammals. We will test the hypothesis that the evolution of mammary glands and X chromosome inactivation has resulted in modification of the BRCA1 protein sequence as it aquired new roles in these processes. We will also investigate the importance of these changes inducing compensatory changes in other parts of the protein.
The Structure of Moral Reasoning: Hume, Kant and the Evidence from Psychopathology and Neuroscience. What can moral philosophers hope to learn from the sciences of the mind? Recent work on the disorders of autism and psychopathy, has promised to reshape a longstanding philosophical debate between Kantians and Humeans on the role of empathy (sympathy) in moral thinking. This project will draw out the implications of a range of neuroscientific findings for key questions in moral theory and also co ....The Structure of Moral Reasoning: Hume, Kant and the Evidence from Psychopathology and Neuroscience. What can moral philosophers hope to learn from the sciences of the mind? Recent work on the disorders of autism and psychopathy, has promised to reshape a longstanding philosophical debate between Kantians and Humeans on the role of empathy (sympathy) in moral thinking. This project will draw out the implications of a range of neuroscientific findings for key questions in moral theory and also consider how the normative and conceptual claims made by such theories, about what must be true of a moral judgment, are connected to descriptive claims about the psychology of the moral agents who make them.Read moreRead less
Time and timelessness in Aboriginal societies as exemplified in Ngarinyin body-imagery. My project is an investigation of northern Kimberley trading practices, arguing against some pervasive views in the Aboriginalist literature which cast Aboriginal people and cultures as emphasising timelessness and de-emphasising human creativity. Kimberley trading/sharing practices, I suggest, show that exchanges (at various levels of formality) between groups and individuals are locally experienced as an ac ....Time and timelessness in Aboriginal societies as exemplified in Ngarinyin body-imagery. My project is an investigation of northern Kimberley trading practices, arguing against some pervasive views in the Aboriginalist literature which cast Aboriginal people and cultures as emphasising timelessness and de-emphasising human creativity. Kimberley trading/sharing practices, I suggest, show that exchanges (at various levels of formality) between groups and individuals are locally experienced as an active and ongoing participation in the creation of the bodies of kin and of the country itself. This is done in a way which actively participates in, rather than merely reproduces, the creative travels of the first ancestral beings. Phenomenology and psychoanalysis theoretically inform my approach.Read moreRead less
Development of Model Systems to Investigate Blood Hydrodynamic Parameters Affecting Blood Cell Function: An Interdisciplinary Approach. National benefit will come through this research contributing to a better understanding of blood flow biology and pathology, both of which are of particular relevance to the aging Australian population. This benefit is well aligned with the 2008 National research priority 2: Promoting and Maintaining Good Health; Priority Goal 3. Preventative Health. The synthes ....Development of Model Systems to Investigate Blood Hydrodynamic Parameters Affecting Blood Cell Function: An Interdisciplinary Approach. National benefit will come through this research contributing to a better understanding of blood flow biology and pathology, both of which are of particular relevance to the aging Australian population. This benefit is well aligned with the 2008 National research priority 2: Promoting and Maintaining Good Health; Priority Goal 3. Preventative Health. The synthesis of both extensive expertise in platelet/cardiovascular research and bioengineering/rheology should provide a substantial platform from which fundamental new discoveries in this niche area can be made. The development of novel platelet analysis tools arising from this work may also ultimately lead to new intellectual property and attract industry based funding.Read moreRead less
Using nanostructured biomaterials and stem cells to repair spinal cord injuries. There is currently no effective cure for spinal cord injuries and the consequences to the patient are devastating. Spinal cord injuries affects limb, bowel, bladder and sexual function, and many people with these injuries strugle to maintain their independence. Because people can live for many years after spinal cord damage, the financial and social costs are immense, as many are dependent on the help of others for ....Using nanostructured biomaterials and stem cells to repair spinal cord injuries. There is currently no effective cure for spinal cord injuries and the consequences to the patient are devastating. Spinal cord injuries affects limb, bowel, bladder and sexual function, and many people with these injuries strugle to maintain their independence. Because people can live for many years after spinal cord damage, the financial and social costs are immense, as many are dependent on the help of others for their survival. This proposal tackles this urgent problem by applying advanced nanostructured materials with stem cells, to assist the body in the repair of the spinal cord following injury. Read moreRead less
How free is free?: word order in Australian Indigenous languages. This project aims to address the fundamental issue of how the grammatical structure of the language we speak shapes the way we plan and interpret sentences. The project will use innovative methodologies to investigate language production and comprehension in three Australian Indigenous languages that have unusually free word order, where the words in a sentence can be varied in multiple ways without changing the overall meaning. E ....How free is free?: word order in Australian Indigenous languages. This project aims to address the fundamental issue of how the grammatical structure of the language we speak shapes the way we plan and interpret sentences. The project will use innovative methodologies to investigate language production and comprehension in three Australian Indigenous languages that have unusually free word order, where the words in a sentence can be varied in multiple ways without changing the overall meaning. Expected outcomes include new knowledge of the relationship between language structure and human cognition, a deeper understanding of the grammatical structure of three Indigenous languages and how they differ from other languages, and important contributions to Indigenous language maintenance and education.Read moreRead less