Testing A Tailored, Evidence-based Education Intervention To Enhance Outcomes For Patients Commencing Chemotherapy
Funder
National Health and Medical Research Council
Funding Amount
$311,250.00
Summary
This project tests an innovative education program aimed at reducing the physical and psychosocial burden experienced during a course of cancer chemotherapy. The aim of the study is to reduce the burden and distress associated with cancer chemotherapy. Cancer chemotherapy is associated with physical (nausea, fatigue, hair loss, infection) and psychosocial (fear, anxiety, worry about family) effects that cause significant distress. Patients experience a highly level of pre-treatment anxiety and f ....This project tests an innovative education program aimed at reducing the physical and psychosocial burden experienced during a course of cancer chemotherapy. The aim of the study is to reduce the burden and distress associated with cancer chemotherapy. Cancer chemotherapy is associated with physical (nausea, fatigue, hair loss, infection) and psychosocial (fear, anxiety, worry about family) effects that cause significant distress. Patients experience a highly level of pre-treatment anxiety and for many this distress lasts across the course of treatment. Over the past decade there has been a dramatic shift in chemotherapy delivery to the outpatient setting. This means that patients are now responsibile for monitoring their own health at home and may need to use self-care strategies to deal with the many adverse effects of treatment. Pre-treatment education has usually focused on providing information about the facts of treatment, i.e. likelihood of nausea, rather than preparing the patient for the experience of treatment or helping them to manage the self-care demands associated with receiving treatment in the outpatient setting. The innovative education program tested here is the first of its type to draw on high level research evidence about preparing patients for potentially threatening medical procedures, tailoring this education to the individual situation of the patient and coaching the patient to implement evidence-based self-care behaviours and to use stress reduction techniques across the course of treatment.Read moreRead less
In 2013 there were ~200 million clinical cases of malaria, causing ~600,000 deaths. All antimalarial drugs are now associated with malaria parasite resistance. Thus, new therapies are urgently needed, including new drugs to prevent this disease. We have made the exciting discovery that an existing antimalarial drug can kill malaria parasites in a unique, previously unknown, manner. Here, we will investigate how this occurs and develop new drug candidates for malaria prevention.
Does Australian Corporate Taxation Matter? On a GDP-weighted basis the average OECD corporate rate has fallen from 44 percent in 1985 to 31 percent in 2004. Australia operates a flat thirty percent corporate tax rate and this compares well with the current OECD average. Yet, the Business Council of Australia argues that the Australian corporate tax rate is 'uncompetitive'. Certainly, the corporate tax burden (i.e. corporate tax revenue as a proportion of GDP) is very high in Australia, the thi ....Does Australian Corporate Taxation Matter? On a GDP-weighted basis the average OECD corporate rate has fallen from 44 percent in 1985 to 31 percent in 2004. Australia operates a flat thirty percent corporate tax rate and this compares well with the current OECD average. Yet, the Business Council of Australia argues that the Australian corporate tax rate is 'uncompetitive'. Certainly, the corporate tax burden (i.e. corporate tax revenue as a proportion of GDP) is very high in Australia, the third highest in the OECD, and the highest in the Asia-Pacific region. This project will evaluate the extent that the corporate tax burden is a hinderance to Australian firms and economic behaviour. Read moreRead less
Cognitive Outcome And Therapeutic Interventions For Coronary Artery Disease.
Funder
National Health and Medical Research Council
Funding Amount
$392,104.00
Summary
Dementia is recognized as an increasingly important factor affecting quality of life as people age. Deaths from heart disease are declining, in part due to improved surgical techniques and to the use of less invasive methods to keep arteries open such as coronary stenting. It is now well known that 20 to 60% of patients experience some degree of impairment in thinking ability (cognitive impairment) after cardiac surgery, that this will persist in some of these individuals for years and may incre ....Dementia is recognized as an increasingly important factor affecting quality of life as people age. Deaths from heart disease are declining, in part due to improved surgical techniques and to the use of less invasive methods to keep arteries open such as coronary stenting. It is now well known that 20 to 60% of patients experience some degree of impairment in thinking ability (cognitive impairment) after cardiac surgery, that this will persist in some of these individuals for years and may increase the risk of long-term problems. Cognitive impairment affects people in many ways. While it is not yet known whether the occurrence of cognitive impairment predisposes to dementia, it is thought that Mild Cognitive Impairment (MCI) may do so. We propose to explore the link between MCI and Post Procedural Cognitive Deficit (PPCD) in patients with coronary disease from before the first point of objective diagnosis, i.e. prior to the coronary angiogram, and over a 12-month period, through and subsequent to further treatment interventions such as stenting or cardiac surgery. Our Pilot data suggest that PPCD does indeed occur after angiography, and we propose to identify how long this lasts, whether MCI predisposes to it and whether it is better to wait until it resolves before further interventions are undertaken. In this way we hope to identify the safest treatment strategy for patients with coronary disease that will minimize the occurrence of Cognitive Deficit and possibly longer-term cognitive changes after investigation and treatment for their symptoms.Read moreRead less
Using eye movements to study how past experiences shape expectations. We intend to examine how the brain decides where to look next with our eyes, a decision made approximately three times every second. Understanding how the normal brain makes decisions will in turn help us to understand what happens when things go wrong in diseases like dementia and Parkinson's disease, with the hope of better - and earlier - diagnosis, and improved monitoring of treatment. In addition, our research will establ ....Using eye movements to study how past experiences shape expectations. We intend to examine how the brain decides where to look next with our eyes, a decision made approximately three times every second. Understanding how the normal brain makes decisions will in turn help us to understand what happens when things go wrong in diseases like dementia and Parkinson's disease, with the hope of better - and earlier - diagnosis, and improved monitoring of treatment. In addition, our research will establish an important research link with The University of Cambridge, and allow Australia to be competitive with laboratories in North America and Europe that are currently studying how the brain makes decisions about where to look.Read moreRead less
Getting back on track after the unexpected happens: decision making in predictable and unpredictable environments. This project intends to examine how the brain decides where to look next with our eyes, a decision made approximately three times every second. Understanding how the normal brain makes decisions will in turn help us to understand what happens when things go wrong in diseases like dementia and Parkinson's disease.
Effects on Labour Supply, Savings and Welfare of the July 2007 Policy Changes to Superannuation and the Age Pension. This proposal's central question falls within the priority goal of 'Strengthening Australia's social and economic fabric'. Understanding the effects of alternative superannuation tax arrangements is crucial in view of concerns regarding aggregate private savings and labour force participation in an ageing economy. Low savings or participation could have implications for sustained ....Effects on Labour Supply, Savings and Welfare of the July 2007 Policy Changes to Superannuation and the Age Pension. This proposal's central question falls within the priority goal of 'Strengthening Australia's social and economic fabric'. Understanding the effects of alternative superannuation tax arrangements is crucial in view of concerns regarding aggregate private savings and labour force participation in an ageing economy. Low savings or participation could have implications for sustained economic growth. This project's outcomes will provide an indication of the potential effects of policies on labour supply and savings. After further modifications, the model developed in this project can also address other questions in the context of life-cycle decisions under uncertainty, such as labour supply, fertility or health.Read moreRead less
Managing an ageing population for income adequacy and fiscal sustainability. This project aims to improve understanding of the impacts of existing key reforms intended to ease fiscal pressures associated with population ageing. The right mix of retirement income policies is vital to Australia's fiscal sustainability, however the effectiveness of existing policies is unknown. The project expects to identify impacts of key reforms on employment, re-training, income, savings and future retirement i ....Managing an ageing population for income adequacy and fiscal sustainability. This project aims to improve understanding of the impacts of existing key reforms intended to ease fiscal pressures associated with population ageing. The right mix of retirement income policies is vital to Australia's fiscal sustainability, however the effectiveness of existing policies is unknown. The project expects to identify impacts of key reforms on employment, re-training, income, savings and future retirement income and public pension receipt. The project will develop a new tax records-based dataset to facilitate future research on tax and welfare systems.Read moreRead less
A computational and experimental investigation of reading aloud: Dyslexia, disyllables, and beyond. Australia is a world leader in computational cognitive science, particularly with respect to language processing. This project will help maintain and extend this position. Insights from the project will help us understand the processes that underlie both normal reading and reading disorders, particularly in areas that are comparatively neglected yet extremely important, such as how people read wor ....A computational and experimental investigation of reading aloud: Dyslexia, disyllables, and beyond. Australia is a world leader in computational cognitive science, particularly with respect to language processing. This project will help maintain and extend this position. Insights from the project will help us understand the processes that underlie both normal reading and reading disorders, particularly in areas that are comparatively neglected yet extremely important, such as how people read words of more than one syllable. Given that everyone in Australian needs to learn to read and that acquired and developmental disorders of reading are common, providing the theoretical base on which the processes involved in reading can be understood (and hence learnt and remediated most effectively) is of utmost importance.Read moreRead less
An innovative theory driven approach to enhancing situation awareness among road users in Australia. This project will develop, via on-road studies exploring road user behaviour, a first of its kind systems theoretic model of situation awareness (SA) for road transport. The model will then be used to inform the development of roadway design solutions to enhance road user SA, which will be tested through advanced simulation.