The Impact Of Circadian Disturbances On Sleep Quality, Cognition And Psychiatric Symptoms In Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$496,340.00
Summary
There is an increasing awareness that neurodegenerative diseases are associated with disturbances in sleep. Our group have recognised that patterns of sleep disturbance in these patients are also related to problems with memory and mood. The proposed study will be the first of its kind to explore whether disruptions in the circadian system represent a common mechanism underlying these comorbid disease features. Understanding this pathology will hopefully lead to the development of new therapies.
Benefits Of Home-based Multidisciplinary Rehabilitation In Non Small Cell Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$581,039.00
Summary
Lung cancer is the third leading cause of death in Australia. People with lung cancer experience a complex mix of symptoms that can provoke significant distress and impair physical function. This study aims to develop and test a home based exercise and self-management support program to increase function and physical activity levels, reduce levels of depression and improve quality of life of people with lung cancer.
Moving Behavioural Neuroscience & Neuroeconomics Into Dementia Prevention: Spatial Tracking And Economic Decision-making As New Sensitive Measures Of Daily Function
Funder
National Health and Medical Research Council
Funding Amount
$595,588.00
Summary
This project will aim to develop new measures for clinical trials by learning the relationship between older people's movements around the house, ability to make decisions about their health and finance and their cognitive performance. These instruments may aid future trials of drugs and other interventions for preventing dementia by indicating how basic behavioural patterns respond to interventions.
Modifiable Risks And Interventions For Cognitive Decline, Depression And Dementia In Older People
Funder
National Health and Medical Research Council
Funding Amount
$430,055.00
Summary
This research proposal will explore the modifiable risk factors for cognitive decline (ie. changes in memory and thinking functions) in older people. It will examine the pertinence of critical contributors to glial-neuronal networks including depression, cardiovascular disease, sleep-wake systems, mental and physical exercise, inflammatory processes and diet, as well as test interventions that target these risk factors. It will use sophisticated brain scanning methods to examine which factors pr ....This research proposal will explore the modifiable risk factors for cognitive decline (ie. changes in memory and thinking functions) in older people. It will examine the pertinence of critical contributors to glial-neuronal networks including depression, cardiovascular disease, sleep-wake systems, mental and physical exercise, inflammatory processes and diet, as well as test interventions that target these risk factors. It will use sophisticated brain scanning methods to examine which factors promote neuroplasticity.Read moreRead less
Modifying The Trajectory Of Insidious Late Life Cognitive Decline Using Computerised Cognitive Training
Funder
National Health and Medical Research Council
Funding Amount
$743,152.00
Summary
Supervised, group-based computerised cognitive training (CCT) is a safe and effective intervention to maintain cognition in healthy older adults. This project will examine the extent to which CCT can attenuate or even reverse the rate of decline in older people with previously documented cognitive decline, as well as strategies to maintain CCT effects in the long term.
A Selective Prevention Trial Using Novel Pharmacotherapies In An Older Age Cohort At Risk For Depression
Funder
National Health and Medical Research Council
Funding Amount
$975,259.00
Summary
The study will examine whether omega-3 fatty acids or antidepressants prevent the onset of depression in a group of older community participants who have previously been identified as being "at risk" of depression. The study will incorporate sophisticated brain scanning methods, as well as tests of brain functioning to determine acute brain changes, reduction in cognitive decline and prevention of depression over a one-year period.