Defining The Genetic Requirements For Maintenance Of Colorectal Cancer
Funder
National Health and Medical Research Council
Summary
Colorectal cancer is the second leading cause of cancer-related death worldwide because there are few effective treatments for people with aggressive disease. The goal of this project is to uncover how normal colon cells suppress cancerous changes and to identify the important factors that colon cancer cells depend on for survival and growth. With this knowledge we can begin to develop more effective cancer treatments with fewer side-effects.
The Contribution Of Gp130-Stat3 During Wnt-beta-catenin Induced Intestinal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$396,275.00
Summary
There is growing evidence that cancer is initiated and develops not by the deregulation of a single gene or signaling pathway, but by multiple events. We will study the co-operation between two pathways - gp130-Stat and Wnt. These signaling pathways are frequently deregulated in many types of cancer, however their interaction remains poorly understood. We shall explore their mechanism of interaction during intestinal cancer in order to develop a novel therapeutic target for this disease.