Defining The Genetic And Epigenetic Targets Involved In Serrated Neoplasia Of The Colorectum
Funder
National Health and Medical Research Council
Funding Amount
$324,122.00
Summary
We believe that some colon cancers develop from a type of polyp called a hyperplastic polyp and that many of these polyps contain a specific mutation in a gene called BRAF. We are conducting tumour studies using mouse models that carry different mutated genes to understand their role and importance in the pathway by which these cancer evolve. Understanding this will allows us to develop better treatments for pateints suffering from colon cancer.
I am a molecular-cell biologist determining the molecular regulation, cellular localisation and function of tumour suppressor proteins in cancer. We aim to elucidate pathways that can ultimately be targeted for intervention in breast and colon cancer.