Image processing techniques for artificial human vision systems. Blindness affects millions of people worldwide and over 100,000 Australians. Our project supports quality of life improvements for them by developing image processing techniques necessary for artificial human vision systems: "bionic eyes". Our approach will extract the most visually informative content in a scene,allowing low resolution images to be generated which optimise usage of the limited number of eletrodes available in prot ....Image processing techniques for artificial human vision systems. Blindness affects millions of people worldwide and over 100,000 Australians. Our project supports quality of life improvements for them by developing image processing techniques necessary for artificial human vision systems: "bionic eyes". Our approach will extract the most visually informative content in a scene,allowing low resolution images to be generated which optimise usage of the limited number of eletrodes available in prototype bionic eye implants. Psychophysical tests presenting such modified images to normally sighted participants will verify the effectiveness of this approach. The techniques developed will provide a real-time image processing toolkit for visual protheses, with significant commercial and social benefits including enhancement of Australilia's neuroprostheses industry profile.Read moreRead less
Broad spectrum nanomedicine for Meningitis treatment. Brain inflammatory diseases are among the top ten infectious causes of death. The project aims to provide Australian doctors with a superior alternative of treating infections that do not respond to conventional antibiotics. The nanomedicine developed will reduce the burden of hospital and boost Australia economy in the biomedical sector.
Advanced micro-architecture and nanotopography for enhanced tissue growth in scaffolds. Tissue engineering scaffolds offer an urgently needed synthetic biomaterials solution to overcome disease transmission from donor transplants. This work will combine biomaterial chemistry and designed surface topography to trigger bone formation within a scaffold for the first time in the world. Collaboration with national research leaders on stem cell and animal testing of the new scaffolds will provide the ....Advanced micro-architecture and nanotopography for enhanced tissue growth in scaffolds. Tissue engineering scaffolds offer an urgently needed synthetic biomaterials solution to overcome disease transmission from donor transplants. This work will combine biomaterial chemistry and designed surface topography to trigger bone formation within a scaffold for the first time in the world. Collaboration with national research leaders on stem cell and animal testing of the new scaffolds will provide the necessary interdisciplinary approach to generate a new product for patients in need of bone regeneration. Australia will benefit from the contribution to medical science, the development of a new device for rapid prototyping tissue engineering scaffolds, retain biomaterials research expertise, and generate new biomedical products.Read moreRead less
Functional Electronic Stimulation of Muscles - Development of a Model for Sensory Feedback to Amputees and Vision for the Blind. Electrical stimulation of nerve fibres is an emerging physiological technique with great promise towards rehabilitation. The field lacks techniques for detailed, focal application of stimuli to recruit specific fibres for fine muscle control or conveying useful neurosensory information. The investigator has developed microtechnology for delivering stimuli to 100 sites, ....Functional Electronic Stimulation of Muscles - Development of a Model for Sensory Feedback to Amputees and Vision for the Blind. Electrical stimulation of nerve fibres is an emerging physiological technique with great promise towards rehabilitation. The field lacks techniques for detailed, focal application of stimuli to recruit specific fibres for fine muscle control or conveying useful neurosensory information. The investigator has developed microtechnology for delivering stimuli to 100 sites, conceivably facilitating recruitment of specific fibres within a given bundle. Effects of muscle stimulation are readily measured and shall be used to model and refine techniques for generic high-resolution fibre recruitment. Benefits include, improved muscle control in functional electrical stimulation, sensory perception for amputees and patterned vision from optic nerve stimulation.Read moreRead less
Conformal Bionics - addressing the challenges in bringing miniaturised implants to the site of therapeutic delivery. Smaller, more sophisticated, lifetime-implantable bionic devices capable of being placed at the site of therapeutic delivery will facilitate new or improved opportunities for treatment of disease. Three critical areas of research aim to be explored in pursuit of this goal will be addressed within this study: introduction of new fabrication materials that enable devices to conform ....Conformal Bionics - addressing the challenges in bringing miniaturised implants to the site of therapeutic delivery. Smaller, more sophisticated, lifetime-implantable bionic devices capable of being placed at the site of therapeutic delivery will facilitate new or improved opportunities for treatment of disease. Three critical areas of research aim to be explored in pursuit of this goal will be addressed within this study: introduction of new fabrication materials that enable devices to conform to the anatomy of the targeted site of therapeutic delivery; improved means of addressing the data and energy transfer needs of devices implanted in confined spaces; and innovation of novel sensors for testing and monitoring of atmospheric conditions within the implant to anticipate and safely manage issues relating to a breach of hermetic encapsulation barriers.Read moreRead less
Large-scale Parallelization of Neural Stimulation in a Visual Prosthesis. Over time, engineers have been able to treat a large number of disorders through new technologies. For example, the deaf can now hear again through cochlear implants. Similar efforts to provide vision to the blind, however, have met with difficulties owing to the high quantities of sites that must be stimulated to provide 'useful' vision. This study addresses the important issues relating to the delivery of large quantitie ....Large-scale Parallelization of Neural Stimulation in a Visual Prosthesis. Over time, engineers have been able to treat a large number of disorders through new technologies. For example, the deaf can now hear again through cochlear implants. Similar efforts to provide vision to the blind, however, have met with difficulties owing to the high quantities of sites that must be stimulated to provide 'useful' vision. This study addresses the important issues relating to the delivery of large quantities of electrical stimulations to surviving nerves in the eyes of blind patients in an effort to devise a beneficial visual prosthesis or 'bionic eye'. The outcomes of this study could substantially enhance Australia's already prominent reputation in neurostimulation and provide much needed treatments to vision disorders.Read moreRead less
Image-guided skin microbiopsy technology development. There is a need for targeted biopsies in dermatology. This novel technology enables minimally invasive biopsies to be taken from suspicious skin lesions by integrating micromedical and imaging devices.
Ultra-low fouling active surfaces. This project aims to develop chemistries and fabrication approaches through innovative materials evaluation to develop ultra-low fouling active electrode surfaces. Development of ultra-low fouling surfaces will have significant impact in a range of applications where system or device failure is attributed to fouling. The growing field of bionics, where implantable electronic devices interface directly with the nervous system, is one such device. The expected ou ....Ultra-low fouling active surfaces. This project aims to develop chemistries and fabrication approaches through innovative materials evaluation to develop ultra-low fouling active electrode surfaces. Development of ultra-low fouling surfaces will have significant impact in a range of applications where system or device failure is attributed to fouling. The growing field of bionics, where implantable electronic devices interface directly with the nervous system, is one such device. The expected outcomes will be an understanding of the material requirements that lead to the elimination of protein and cell accumulation at surfaces that degrades the performance and lifetime of these implants. The findings will benefit any application where fouling is a problem.Read moreRead less
Quantitative multi-modal optical imaging of deep tissue. This project aims to create new tools to quantify the structural and functional properties of tissue. Combining multiple optical imaging technologies (multi-modal) into a single, miniaturised probe, these tools could enable physiologists and biomedical researchers to obtain new insight into disease. Encasing the highly miniaturised probe within a medical needle is aimed to allow insertion of the 'needle probe' deep into tissue, extending o ....Quantitative multi-modal optical imaging of deep tissue. This project aims to create new tools to quantify the structural and functional properties of tissue. Combining multiple optical imaging technologies (multi-modal) into a single, miniaturised probe, these tools could enable physiologists and biomedical researchers to obtain new insight into disease. Encasing the highly miniaturised probe within a medical needle is aimed to allow insertion of the 'needle probe' deep into tissue, extending optical imaging to areas not previously accessible. The project could develop novel quantification models to allow longitudinal assessment and comparison between subjects. Validating the tools with specific biomarkers, it could provide outcomes in breast and liver cancer, and a framework to explore other diseases.Read moreRead less
A comprehensive framework for interactive home telehealth research. We propose the development of a comprehensive research framework for the next generation of home telecare technology. The framework will support the unattended recording of patient physiological data and allow for patient management and information review by health professionals. It will include knowledge management tools to support clinical decision making. Research will also be conducted into the development of mobile communit ....A comprehensive framework for interactive home telehealth research. We propose the development of a comprehensive research framework for the next generation of home telecare technology. The framework will support the unattended recording of patient physiological data and allow for patient management and information review by health professionals. It will include knowledge management tools to support clinical decision making. Research will also be conducted into the development of mobile community networks and ambulatory monitoring technologies based around Bluetooth piconets.
The long-term outcomes of this research will be improved patient health outcomes in the chronically ill and a decreased overall health care expenditure by reducing hospital admissions.Read moreRead less