Probiotic Prawn Oral Immunotherapy (ProPIT) For Treatment Of Prawn Allergy
Funder
National Health and Medical Research Council
Funding Amount
$1,865,369.00
Summary
A ‘curative’ food allergy treatment is needed to prevent deaths and improve care. We recently showed that probiotic peanut oral immunotherapy (PPOIT) was highly effective for treating peanut allergy. 82% of PPOIT treated children gained tolerance compared to 4% of the placebo group. We will now test the combined probiotic-food OIT approach for treating prawn allergy. If successful, we will have identified the first treatment for prawn allergy and a platform treatment for other food allergies.
The Kids in Communities Study: national investigation of community level effects on children's developmental outcomes. This project (a cross-disciplinary collaboration) will investigate community level factors influencing early childhood developmental outcomes using a mixed methods approach in up to 10 communities across Australia. This will result in a potential set of measures or indicators that reflect communities that are good for children.
Which Heart Failure Intervention Is Most Cost Effective In Reducing Hospital Care (WHICH? II) Trial: A Multicentre, Randomised Trial Of Standard Versus Intensified Management Of Metropolitan And Regional-dwelling Patients With Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$1,891,210.00
Summary
Chronic heart failure (CHF) management programs are now the gold-standard to cost-effectively care for thousands of Australians hospitalised with CHF each year. We’ve shown that home-based management is most cost-effective in reducing hospital stay in CHF. The Which Intervention is most Cost-effective in reducing Hospital care (WHICH? II) Trial, a multicentre, randomised study, will determine if more intensive care (via home visits and remote care contacts) further improves poor outcomes in CHF.
Building connections: schools as community hubs. This project aims to support school systems and planning authorities enhance engagement between schools and local communities. The key objective is to advance the cost-effective development of the infrastructure required to deliver community programs and services from school sites, in addition to education programs for school-aged students. The project expects to generate new knowledge about how best to plan, design, govern and manage facilities a ....Building connections: schools as community hubs. This project aims to support school systems and planning authorities enhance engagement between schools and local communities. The key objective is to advance the cost-effective development of the infrastructure required to deliver community programs and services from school sites, in addition to education programs for school-aged students. The project expects to generate new knowledge about how best to plan, design, govern and manage facilities and infrastructure to enable schools to operate successfully as more than a school, encouraging the development of resilient and connected communities. The outcomes are expected to include a development framework for maximising schools as community hubs.Read moreRead less
Outcomes of collective action: After the blockade, what next? The project intends to study how collective actors react when conventional or radical collective action succeeds or fails. If a democratic protest rally is ignored by authorities, does support for violence increase? If a turbulent riot attracts favourable media attention and concessions, does this increase the likelihood of future riots or undercut them? This project aims to answer these questions. It plans to test a new, theoreticall ....Outcomes of collective action: After the blockade, what next? The project intends to study how collective actors react when conventional or radical collective action succeeds or fails. If a democratic protest rally is ignored by authorities, does support for violence increase? If a turbulent riot attracts favourable media attention and concessions, does this increase the likelihood of future riots or undercut them? This project aims to answer these questions. It plans to test a new, theoretically integrative model of collective action and the intergroup dynamic, using a mixed-methods approach including experiments, small group research and longitudinal field surveys. Project outcomes may provide an evidence basis for policy-makers' debates about trajectories of radicalisation and deradicalisation, and for recommendations about engagement and negotiation of tactics for activists, political parties, and nongovernment organisations.Read moreRead less
Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliance ....Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliances with the government, industry and community partners will develop a practice framework to prevent everyday harms and the escalation to abuse, and to promote safety and wellbeing. The research has policy benefits for capacity-building in the sector to act on the rights and voices of people with disability. Read moreRead less
Strengthening Relationships for Young People in Residential Care. Young people in residential care face major challenges in forming positive relationships, many having experienced adults as a source of threat rather than safety. This project aims to investigate practices within therapeutic residential care that enable or limit young people’s identity formation, positive social connections, safety and wellbeing. This research will generate nuanced knowledge informing interpersonal and institution ....Strengthening Relationships for Young People in Residential Care. Young people in residential care face major challenges in forming positive relationships, many having experienced adults as a source of threat rather than safety. This project aims to investigate practices within therapeutic residential care that enable or limit young people’s identity formation, positive social connections, safety and wellbeing. This research will generate nuanced knowledge informing interpersonal and institutional change. Expected outcomes include improved approaches to therapeutic care and to methods for enabling the participation of young people in care in matters that may change their life trajectory on exiting care. Expected benefits include more responsive policies and frameworks for practice.Read moreRead less
What Cost-effective Built Environment Interventions Would Create Healthy, Liveable And Equitable Communities In Australia, And What Would Facilitate These Being Translated Into Policy And Practice?
Funder
National Health and Medical Research Council
Funding Amount
$2,658,832.00
Summary
This CRE involves collaboration between a multi-disciplinary research team across Australia working with policy-makers covering planning, urban design, transport planning and health. It will identify the most cost-effective built environment interventions required to create healthy, liveable, and equitable communities. Factors that influence research findings being translated into urban planning policy and practice will be examined and tools to assist changes to policy and practice developed.
Beyond safety: Ethical practice involving children. This project aims to investigate the role of ethical practice in improving child safety. Focusing especially on those who are at greater risk of harm, the findings will contribute to ensuring Australia’s children are safe and treated with dignity and respect. Expected outcomes include better-targeted, child-informed policy and practice for organisations involved with children, and important knowledge for organisations seeking to optimise, promo ....Beyond safety: Ethical practice involving children. This project aims to investigate the role of ethical practice in improving child safety. Focusing especially on those who are at greater risk of harm, the findings will contribute to ensuring Australia’s children are safe and treated with dignity and respect. Expected outcomes include better-targeted, child-informed policy and practice for organisations involved with children, and important knowledge for organisations seeking to optimise, promote and protect children’s safety and wellbeingRead moreRead less
Killing which averts suffering: the role of norms and empathy. Abattoir workers and butchers kill animals to prepare food, farmers to cull stock, and veterinarians to alleviate suffering. Soldiers kill other humans in war, police or security guards to protect the public, and doctors to enact legal euthanasia. Research shows that these tasks can be confronting, and even traumatic. This project aims to test the processes through which people learn socially supported palliative killing to avert suf ....Killing which averts suffering: the role of norms and empathy. Abattoir workers and butchers kill animals to prepare food, farmers to cull stock, and veterinarians to alleviate suffering. Soldiers kill other humans in war, police or security guards to protect the public, and doctors to enact legal euthanasia. Research shows that these tasks can be confronting, and even traumatic. This project aims to test the processes through which people learn socially supported palliative killing to avert suffering and their neural underpinnings, with a focus on norms and empathic distress. It will focus on two core samples: veterinarians, who must euthanize animals, and health practitioners in Victoria, where legal changes will introduce ‘voluntary assisted dying’ in mid-2019. It will investigate how practitioners learn palliative killing, and what the impact is on psychological variables such as empathy and identity. It will generate new understandings of social influence around life and death decisions, provide an evidence basis to inform policy makers, and help institutions and practitioners seeking to manage distress and respond to fast-moving, controversial policy changes.Read moreRead less