Investigating The Effects Of Macrolides On Excessive Synthesis And Secretion Of Airway Mucins Using Novel Ex Vivo And In Vivo Approaches
Funder
National Health and Medical Research Council
Funding Amount
$520,821.00
Summary
Many people have difficulty breathing because the airway tubes that move air in and out of their lungs are blocked by excessive amounts of sticky mucus. Our project will use new techniques developed in our laboratories to investigate whether a group of medicines called “macrolides” can prevent the excessive production and release of mucus in the airways, and thus be beneficial in treating asthma, and potentially other lung diseases.
Genome-wide Association Study (GWAS) For Juvenile-onset Myopia And Its Component Measures To Identify Molecular Pathways To Prevent Myopia
Funder
National Health and Medical Research Council
Funding Amount
$495,364.00
Summary
We will examine 2,000 young adults from the Western Australian Raine Cohort at the Lions Eye Institute / University of Western Australia. Ocular data will be collected relating to myopia (short-sightedness) and will be combined with extensive previous childhood and genetic research data collected on the Cohort, to investigate the genetic and environmental factors predisposing to myopia. This will assist in understanding the factors leading to myopia.
REACH: Randomised Trial Of EArly Rehabilitation In Congenital Hemiplegia
Funder
National Health and Medical Research Council
Funding Amount
$972,777.00
Summary
Infants with asymmetric brain lesions are at high risk of congenital hemiplegia. This study compares modified CIMT to an equal dose of bimanual training in 150 infants recruited at 3-6 months. Both therapies will be parent-delivered supported by experienced clinicians. Outcomes include use of the impaired hand in bimanual tasks, cognitive and motor development at 12 and 24 months c.a. with measures of neural structure and functional connectivity at 24 months. Early interventions that attenuate
A Randomised Controlled Trial Of Exercise Programs For Preventing Knee Injuries
Funder
National Health and Medical Research Council
Funding Amount
$1,160,491.00
Summary
The promotion of physical activity, either through organised sport or active recreation, is a key public health strategy in this country. However, there is a risk of injury during this participation and efforts need to be undertaken to reduce this risk so that spor is safe for all. Sports injury prevention efforts to date in Australia have been severely hampered by a lack of evidence supporting currently advocated countermeasures. This concern has been recognised by both the NHMRC and the Common ....The promotion of physical activity, either through organised sport or active recreation, is a key public health strategy in this country. However, there is a risk of injury during this participation and efforts need to be undertaken to reduce this risk so that spor is safe for all. Sports injury prevention efforts to date in Australia have been severely hampered by a lack of evidence supporting currently advocated countermeasures. This concern has been recognised by both the NHMRC and the Commonwealth Department of Health and Ageing. It is imperative that we formally evaluate the effectiveness of sports injury countermeasures in the context of broad community level participation in sport, in contrast to previous research focussed on professional sport, and begin to deliver the preventive measures to the community. Australian football is a popular sport throughout Australia and it is associated with more medically-treated injuries than any other sport. Knee injuries are particularly common and can have severe consequences. One of the most commonly recommended knee injury prevention strategies is a well-designed exercise training program. Despite their potential to significantly reduce injury rates, the effectiveness of exercise training programs to prevent knee injuries in football, and indeed in most other sports, has not previously been assessed but has been identified as a priority research area by the NHMRC. This project will determine the effectiveness of exercise training programs for preventing knee injuries in community-level football players by monitoring injury rates, player behaviours and player attitudes before and after the training programs are implemented.Read moreRead less
The Long-term Consequences Of Assisted Reproduction On The Growth, Metabolic, Respiratory, Psychological, Immunological And Reproductive Development Of The Offspring.
Funder
National Health and Medical Research Council
Funding Amount
$1,552,096.00
Summary
1 in 25 children are born from IVF treatment - incredibly- to our shame; no data exists as to the long-term health of these children. Presented is a unique opportunity, which would be exceedingly difficult to replicate elsewhere in the world, to determine the long-term consequences of IVF upon the development of the offspring, by comparing their growth, metabolic, respiratory, psychological, immunological and reproductive development to a representative sample of WA children- the Raine cohort.
Reducing Prolonged Workplace Sitting Time In Office Workers: A Cluster-randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$524,613.00
Summary
Groundbreaking Australian research shows that sitting for too long, which is routine for most office workers, contributes to overweight and to a greater risk of developing diabetes and heart disease. In over 300 desk-bound office workers, this world-first study will assess the effectiveness of an innovative workplace program aimed at reducing and breaking up sitting time. It will identify practical ways for Australian office workers to minimise unhealthy effects of sitting too much at work.