Molecular mechanisms for seminal fluid signalling in reproduction. Male seminal fluid regulation of the female reproductive process influences fertility and fecundity in humans and animal species. Infertility and impaired reproductive function is a major economic constraint in livestock industries, and carries a substantial social and public health cost in humans. This research will identify the active signalling molecules in seminal fluid and quantify their importance in reproductive success ....Molecular mechanisms for seminal fluid signalling in reproduction. Male seminal fluid regulation of the female reproductive process influences fertility and fecundity in humans and animal species. Infertility and impaired reproductive function is a major economic constraint in livestock industries, and carries a substantial social and public health cost in humans. This research will identify the active signalling molecules in seminal fluid and quantify their importance in reproductive success and health of offspring. The outcomes will inform development of new diagnostic assays for male fertility, and underpin strategic design of novel fertility treatments and products with applications in the human health and animal breeding industries. Read moreRead less
Mechanistic basis of a reproductive lesion in transforming growth factor beta-1 (TGFb1) null mutant mice. Null mutation in the gene encoding the cytokine transforming growth factor beta-1 (TGFb1) causes infertility in male and female mice. In recent experiments we have found that TGFb1 deficiency is associated with impaired ovarian and testicular steroidogenesis, arrested development of pre-implantation embryos and disrupted mammary gland morphogenesis. The aims of the current project are to un ....Mechanistic basis of a reproductive lesion in transforming growth factor beta-1 (TGFb1) null mutant mice. Null mutation in the gene encoding the cytokine transforming growth factor beta-1 (TGFb1) causes infertility in male and female mice. In recent experiments we have found that TGFb1 deficiency is associated with impaired ovarian and testicular steroidogenesis, arrested development of pre-implantation embryos and disrupted mammary gland morphogenesis. The aims of the current project are to unravel the mechanistic basis of the reproductive lesion in TGFb1 null mutant mice and to determine the effect of exogenous systemic delivery of TGFb1 in alleviating this lesion. It is expected that the project will provide new insight into key roles for TGFb1 in governing male and female fertility, and shed light on the prospects for exogenous supplementation of TGFb1 for improving reproductive performance in wild-type animals. This knowledge has potentially important applications in the livestock breeding industry, in devising novel contraceptive vaccine strategies, in the human pharmaceutical industry, and in devising novel contraceptive vaccine strategies.Read moreRead less
Interactions between cells and extracellular matrix in the epithelial-mesenchymal transition of the ovarian follicular stratified epithelium. The lining of many mammalian organs and cavities contain cells that can transform into different cells to bring about organ development or repair but if it goes horribly wrong the cells become metastatic cancers. This project examines the key features of this process especially the roles of matrix that develops around the cells in this process.
Strengthening Australia's Domestic and Family Violence Workforce . This project aims to generate an evidence base on the nature of domestic and family violence (DFV) work and the implications for the DFV workforce across victim, perpetrator and Aboriginal specialist services. Using the innovative method of rapid ethnography, this project expects to provide a comparative understanding of DFV work and workforce practices and requirements. Expected outcomes include workforce development strategies ....Strengthening Australia's Domestic and Family Violence Workforce . This project aims to generate an evidence base on the nature of domestic and family violence (DFV) work and the implications for the DFV workforce across victim, perpetrator and Aboriginal specialist services. Using the innovative method of rapid ethnography, this project expects to provide a comparative understanding of DFV work and workforce practices and requirements. Expected outcomes include workforce development strategies that are responsive to the context and needs of DFV work. Given the high social, health and economic costs of DFV, investing in the DFV workforce has national benefits including improved services and better client and worker wellbeing.
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Identifying and resolving challenges to the effectiveness of collective apologies. It is increasingly common for nations and organisations to apologise for current or past wrongdoing. This research investigates the unique psychological reasons for why collective apologies (as opposed to interpersonal ones) might struggle to win acceptance for victim groups; with an eye to identifying conditions that facilitate intergroup forgiveness.
The psychology of gridlock: Compromise, coalitions, and radicalisation. This project aims to test an innovative psychological model of collective gridlock. Using interviews, surveys, experiments, small group research, and analysis of social media data, the project aims to examine critical pathways in gridlock psychology, where opponents are locked into mutually suboptimal outcomes, unable to move forward. These pathways include the exit or self-censorship of moderates; normative pressure towards ....The psychology of gridlock: Compromise, coalitions, and radicalisation. This project aims to test an innovative psychological model of collective gridlock. Using interviews, surveys, experiments, small group research, and analysis of social media data, the project aims to examine critical pathways in gridlock psychology, where opponents are locked into mutually suboptimal outcomes, unable to move forward. These pathways include the exit or self-censorship of moderates; normative pressure towards purity and refusal to compromise; tactical choices to avoid coalitions; and radicalisation. The research aims to develop novel interventions to reduce polarisation and radicalisation, and to promote compromises, which together will help society respond more nimbly and effectively to social and environmental challenges.Read moreRead less
Understanding vicarious trauma in Australian foster care. This project aims to investigate experiences of vicarious trauma in Australian foster care. This project expects to generate new knowledge about antecedents and mitigators of vicarious trauma, and will do so by using interdisciplinary approaches to understand the specific contexts in which vicarious trauma may occur. Expected outcomes of this project includes the generation of national data about vicarious trauma in foster care through th ....Understanding vicarious trauma in Australian foster care. This project aims to investigate experiences of vicarious trauma in Australian foster care. This project expects to generate new knowledge about antecedents and mitigators of vicarious trauma, and will do so by using interdisciplinary approaches to understand the specific contexts in which vicarious trauma may occur. Expected outcomes of this project includes the generation of national data about vicarious trauma in foster care through the development of a new measure of vicarious trauma. This should provide significant benefits, such as providing a clear means to assessing vicarious trauma, and through the development of a mobile app that will enable foster families in Australia to monitor and report experiences of vicarious trauma.Read moreRead less
Toward a social-psychology of prejudice reduction: Examining lay beliefs. This project aims to expand social–psychological knowledge of prejudice by examining beliefs about what prejudice is, as well as the social and psychological factors affecting these beliefs. If people believe their own intergroup attitudes (even negative ones) to be correct and normative, anti-prejudice appeals will likely be rejected. What is needed, then, is an analysis of what people believe to be prejudice or not in th ....Toward a social-psychology of prejudice reduction: Examining lay beliefs. This project aims to expand social–psychological knowledge of prejudice by examining beliefs about what prejudice is, as well as the social and psychological factors affecting these beliefs. If people believe their own intergroup attitudes (even negative ones) to be correct and normative, anti-prejudice appeals will likely be rejected. What is needed, then, is an analysis of what people believe to be prejudice or not in the first place, and how these beliefs are changed. This project aims to provide this analysis via qualitative and quantitative experimental social-psychological research. Project outcomes are expected to clarify social–psychological theory, offering new insight into how anti-prejudice arguments can be successful.Read moreRead less
How utopian thinking influences political engagement. There is evidence of growing political apathy in many countries. Yet, political disengagement is a serious problem for processes of democracy and the adaptiveness of society. This project draws on recent theorising within the psychological sciences to investigate the role of prospection - the creative imagining of ideal worlds ('utopian thinking') - as a key driver of political engagement. The project will test whether and how utopian thinkin ....How utopian thinking influences political engagement. There is evidence of growing political apathy in many countries. Yet, political disengagement is a serious problem for processes of democracy and the adaptiveness of society. This project draws on recent theorising within the psychological sciences to investigate the role of prospection - the creative imagining of ideal worlds ('utopian thinking') - as a key driver of political engagement. The project will test whether and how utopian thinking stimulates a questioning of the status quo, moral engagement, and the formation of new groups to address social change: outcomes critical for a society to adapt and advance. Educators, government and non-government organisations can draw on project findings to re-engage a disaffected populace.Read moreRead less
Eyewitness identification: Metacognitive influences on choosing behaviour. There is major national and community interest in the successful conduct of criminal investigations. This research addresses the two most significant problems associated with the conduct of eyewitness identification tests: mistaken identifications of innocent suspects and failure to identify guilty suspects when they are present in the lineup. Progress on the latter problem - which results in offenders avoiding detection ....Eyewitness identification: Metacognitive influences on choosing behaviour. There is major national and community interest in the successful conduct of criminal investigations. This research addresses the two most significant problems associated with the conduct of eyewitness identification tests: mistaken identifications of innocent suspects and failure to identify guilty suspects when they are present in the lineup. Progress on the latter problem - which results in offenders avoiding detection - would be a major contribution with national impact. As well as the obvious implications for the conduct of lineups, the international collaboration on the project will increase the visibility of Australian social science research and provide crucial development opportunities for young Australian scientists.Read moreRead less