Psychosocial and economic impacts of rare diseases on Australian children, families and health professionals. Rare childhood diseases have enormous impacts on children and families; health services, and health professionals. This project will enable Australia to lead the international research effort by using a coordinated approach to study the impacts of rare diseases in order to improve psychosocial, health and economic outcomes for children and families.
Genes to phenotype: Exploiting the marsupial model. This research will exploit one of Australia's finest natural resources, its marsupial fauna. The features of marsupial reproduction and development provide a unique opportunity to answer fundamental biological questions. This research will show how the minor differences in key developmental genes that have arisen in their 100 million year isolation give rise to the characteristic differences in developmental timing and reproduction between mar ....Genes to phenotype: Exploiting the marsupial model. This research will exploit one of Australia's finest natural resources, its marsupial fauna. The features of marsupial reproduction and development provide a unique opportunity to answer fundamental biological questions. This research will show how the minor differences in key developmental genes that have arisen in their 100 million year isolation give rise to the characteristic differences in developmental timing and reproduction between marsupials and other mammals. The focus on reproduction and development will also provide invaluable knowledge to underpin efforts to conserve our endangered species and to control those that are overabundant.Read moreRead less
Domestic air quality: towards the setting of guidelines. Air quality standards have been developed to protect human health. Although people spend most of their time indoors there are no standards and only a few guidelines for indoor air pollution (IAP). The aim of this study is to investigate the levels of IAP that may worsen asthma in children. Childhood asthma will be used as a health indicator due to its high prevalence, cost to the healthcare system and implications for respiratory morbidity ....Domestic air quality: towards the setting of guidelines. Air quality standards have been developed to protect human health. Although people spend most of their time indoors there are no standards and only a few guidelines for indoor air pollution (IAP). The aim of this study is to investigate the levels of IAP that may worsen asthma in children. Childhood asthma will be used as a health indicator due to its high prevalence, cost to the healthcare system and implications for respiratory morbidity in adult life. We expect to identify levels of IAP that will represent a health risk as well as the factors that may contribute to increased IAP in homes.Read moreRead less
Extrinsic Control of Mammalian Germ Cell Delineation. Australia is a leader in the recent exciting breakthroughs in reproduction and development, such as cloning and embryonic stem cell propagation, and understanding how germ cells are specified would help us understand the biology underlying specification and developmental potential of all cells. This research will continue to contribute to maintaining Australia's high reputation in advances in reproductive biology. In addition, a greater under ....Extrinsic Control of Mammalian Germ Cell Delineation. Australia is a leader in the recent exciting breakthroughs in reproduction and development, such as cloning and embryonic stem cell propagation, and understanding how germ cells are specified would help us understand the biology underlying specification and developmental potential of all cells. This research will continue to contribute to maintaining Australia's high reputation in advances in reproductive biology. In addition, a greater understanding of marsupial reproduction is a high priority for Australia in the 21st century, with its current unacceptably high rate of mammalian extinctions, for 'we cannot conserve until we comprehend' (Short, 1985).The results therefore are of great potential benefit to society.
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The Kids in Communities Study: national investigation of community level effects on children's developmental outcomes. This project (a cross-disciplinary collaboration) will investigate community level factors influencing early childhood developmental outcomes using a mixed methods approach in up to 10 communities across Australia. This will result in a potential set of measures or indicators that reflect communities that are good for children.
Community spirit, social transformation, sustainable partnership: community capacity building for community transformations. This partnership is at the forefront of developments in the provision of community services. The project will contribute to a growing international field of research focused on developing integrated frameworks for measuring community wellbeing. The community capacity building approach will serve as a best practice model for other Australian municipalities. The indicators a ....Community spirit, social transformation, sustainable partnership: community capacity building for community transformations. This partnership is at the forefront of developments in the provision of community services. The project will contribute to a growing international field of research focused on developing integrated frameworks for measuring community wellbeing. The community capacity building approach will serve as a best practice model for other Australian municipalities. The indicators are a tool for engaging communities in making informal decisions and developing shared goals; a policy tool for evidence based planning; and a reporting tool to track and communicate progress towards agreed goals and outcomes. The outcomes will be efficient use of available funding for community services and lower cost of provision of social welfare.Read moreRead less
Postviral Wheezing In Childhood: Disregulation Of Airway Tone?
Funder
National Health and Medical Research Council
Funding Amount
$577,040.00
Summary
Asthma is a very common childhood condition that is becoming increasingly more common. Wheezing is common in infants and young children following viral infections and is often thought of as the first manifestation of asthma. However, many children and infants who wheeze with viral infections appear to grow out of asthma in their teenage years. Asthma that persists into adult life is usually associated with allergies to common environmental allergens, such as house dust mite and grass pollens. Ho ....Asthma is a very common childhood condition that is becoming increasingly more common. Wheezing is common in infants and young children following viral infections and is often thought of as the first manifestation of asthma. However, many children and infants who wheeze with viral infections appear to grow out of asthma in their teenage years. Asthma that persists into adult life is usually associated with allergies to common environmental allergens, such as house dust mite and grass pollens. However, many infants who wheeze with viral infections, especially in the first year of life, do not develop allergies in later life, raising the possibility that they did not have the same type of asthma as those whose symptoms persist. This project will study the effects of viral infections on lung function to determine whether particular types of virus can have detrimental effects of lung function lasting for years. We will also examine whether the age at which the infection occurs and the severity of the infection influence the long-term outcome. The project involves studying infants during the recovery phase of respiratory viral infections, older children years after documented infections and experimental animal models that have been infected under controlled conditions. By determining whether respiratory viral infections can have long-term effects on lung function that can mimic asthma, we will advance our understanding of how asthma develops. In addition, specific treatment and preventative strategies could then be developed to prevent these long-term abnormalities, instead of relying on asthma medication (especially inhaled corticosteroids) as is the current practice. Preventative strategies could include encouraging the development of specific vaccines.Read moreRead less
Functional-trait approach to restoration of species-rich shrublands. The project aims to deliver management tools that will help mining companies to meet restoration targets and to improve the field of trait-based predictive restoration ecology. Species-rich kwongan shrublands of south-west Australia are a biodiversity treasure. Despite their global and national conservation value, little is known about which plant traits are most important for community assembly and diversity maintenance. This ....Functional-trait approach to restoration of species-rich shrublands. The project aims to deliver management tools that will help mining companies to meet restoration targets and to improve the field of trait-based predictive restoration ecology. Species-rich kwongan shrublands of south-west Australia are a biodiversity treasure. Despite their global and national conservation value, little is known about which plant traits are most important for community assembly and diversity maintenance. This project plans to use plant functional traits related to nutrient and water acquisition to predict plant community assembly under different soil resource availabilities and thus assist in successful rehabilitation of this native vegetation after closure of sand-mining operations.Read moreRead less
Pathways to better practice: developing human resources in child protection services for Indigenous communities in Western Australia and Queensland. This study addresses the serious and escalating problem of providing child protection services to Indigenous children and their families in rural and remote areas. Service delivery to rural and remote environments in Australia is a high cost exercise and, to date, little research has been conducted to understanding the complex nature of professiona ....Pathways to better practice: developing human resources in child protection services for Indigenous communities in Western Australia and Queensland. This study addresses the serious and escalating problem of providing child protection services to Indigenous children and their families in rural and remote areas. Service delivery to rural and remote environments in Australia is a high cost exercise and, to date, little research has been conducted to understanding the complex nature of professional (non-medical) interventions in communities with high proportions of Indigenous families and children. The study, conducted across two states, will contribute to national benefit in 3 key areas: the health and wellbeing of Indigenous children; skills shortage in rural areas and intergenerational change in professional disciplines.Read moreRead less
Bolstering commitment to positive social change through group-based interaction. Building on an impressive series of preliminary results, this research uses small group interaction to bolster commitment to work towards long-term goals. The methods explored in the proposal have the potential to boost commitment in the public, private, and community sectors by identifying the key factors responsible for sustaining long-term change. The research is relevant for efforts to combat racism, and to incr ....Bolstering commitment to positive social change through group-based interaction. Building on an impressive series of preliminary results, this research uses small group interaction to bolster commitment to work towards long-term goals. The methods explored in the proposal have the potential to boost commitment in the public, private, and community sectors by identifying the key factors responsible for sustaining long-term change. The research is relevant for efforts to combat racism, and to increase community support for international development and environmental sustainability. Benefits are expected both in terms of the promotion of positive attitudes in society and in overcoming apathy within organisations.Read moreRead less