Relaxin: molecular mechanisms of action in the reversal of fibrosis. Defects in relaxin and relaxin receptors are increasingly implicated as a cause of fibrosis which is associated with many disease processes. This study will examine the molecular mechanisms linking relaxin and fibrosis and will determine whether relaxin can be used to reverse the condition.
Relaxin action in the heart, kidney, lung and uterus: understanding fibrosis. Relaxin is a peptide hormone associated with pregnancy. We have recently generated a relaxin gene knockout mouse and exciting preliminary data show that without relaxin, non-pregnant mice develop signs of fibrosis in the heart, lung and uterus. Combining our expertise in molecular biology, pharmacology and physiology, the overall objective of this project is to investigate the functions and mechanisms of relaxin action ....Relaxin action in the heart, kidney, lung and uterus: understanding fibrosis. Relaxin is a peptide hormone associated with pregnancy. We have recently generated a relaxin gene knockout mouse and exciting preliminary data show that without relaxin, non-pregnant mice develop signs of fibrosis in the heart, lung and uterus. Combining our expertise in molecular biology, pharmacology and physiology, the overall objective of this project is to investigate the functions and mechanisms of relaxin action in these organs. Our findings will provide important basic information on relaxin physiology and enable us to implement a long-term partnership with Connetics to understand how relaxin regulates collagen production and/or the development of fibrosis.Read moreRead less
Optimising Exercise and Nutrition Throughout the Life Cycle. During the past decade the proportion of Australia's population aged 65 years and over has increased to 13% (2.7 million). During the same period, the proportion of the population aged 85 years and over has more than doubled and is now the fastest growing subpopulation in Australia. As the number of elderly persons continues to grow, sarcopenia-related conditions will have a dramatic and inevitable impact on the lives of all Australian ....Optimising Exercise and Nutrition Throughout the Life Cycle. During the past decade the proportion of Australia's population aged 65 years and over has increased to 13% (2.7 million). During the same period, the proportion of the population aged 85 years and over has more than doubled and is now the fastest growing subpopulation in Australia. As the number of elderly persons continues to grow, sarcopenia-related conditions will have a dramatic and inevitable impact on the lives of all Australians. The novel dietary protocols developed from the results of the studies undertaken in this proposal will translate into better treatment options for reversing age-dependent muscle degeneration. This is a critical first step for improving the standard of living for a large portion of Australian society.Read moreRead less
Novel anti-ageing peptides in the vascular system. The project will substantially improve basic understanding of the ageing process in blood vessels and provide scientific evidence to understand what preventative health care measures might work and why. It will also produce highly skilled and practically trained graduates, ready to contribute to the health industry.
Investigation of the function of Sel S a novel selenoprotein. The long term aim of this project is to find a way to prevent or delay the onset of both Type 1 and Type 2 diabetes. ChemGenex pharmaceuticals, our commercial partners have discovered and patented a selenoprotein with antioxidant properties and have shown in vitro that it protects insulin-producing beta cells from oxidative damage. This project aims to prove, in an in vivo setting, that this protein can prevent or delay the onset of d ....Investigation of the function of Sel S a novel selenoprotein. The long term aim of this project is to find a way to prevent or delay the onset of both Type 1 and Type 2 diabetes. ChemGenex pharmaceuticals, our commercial partners have discovered and patented a selenoprotein with antioxidant properties and have shown in vitro that it protects insulin-producing beta cells from oxidative damage. This project aims to prove, in an in vivo setting, that this protein can prevent or delay the onset of diabetes in mouse models of type 1 and Type 2 diabetes.Read moreRead less
Speaking Greek in diaspora: language contact, survival, and maintenance. Australia is a highly multilingual and multicultural country, speaking several hundred different indigenous and immigrant languages across the nation. Greek is the second largest language spoken in Australia (the second largest country of Greek diaspora in the world). A systematic investigation of the Greek language spoken in Australia by various generations, and its comparison with Greek as spoken in critical locations in ....Speaking Greek in diaspora: language contact, survival, and maintenance. Australia is a highly multilingual and multicultural country, speaking several hundred different indigenous and immigrant languages across the nation. Greek is the second largest language spoken in Australia (the second largest country of Greek diaspora in the world). A systematic investigation of the Greek language spoken in Australia by various generations, and its comparison with Greek as spoken in critical locations in South America, will enhance cross-cultural understanding and communication within Australia and world-wide. The project will fortify the scientific and economic links with the European community already established by the National Centre for Hellenic Studies and Research, in terms of social and economic benefit.Read moreRead less
Activating states: transforming the delivery of 'welfare to work' services to the long-term unemployed in Australia, Great Britain and the Netherlands. With declining unemployment, the possibility of labour force shortages in future years, and an annual expense of $20 billion on income support in Australia, policy makers are concerned with increasing the economic participation of social security recipients. This project will provide policy makers and service providers with important comparative ....Activating states: transforming the delivery of 'welfare to work' services to the long-term unemployed in Australia, Great Britain and the Netherlands. With declining unemployment, the possibility of labour force shortages in future years, and an annual expense of $20 billion on income support in Australia, policy makers are concerned with increasing the economic participation of social security recipients. This project will provide policy makers and service providers with important comparative assessments of the way policies designed to promote economic participation are executed by frontline staff and will provide essential data for designing policy which is more effective in assisting the unemployed to find sustainable paid employment. It will address the National Research Priority of promoting and maintaining good health through strengthening Australia's social and economic fabric.Read moreRead less
Venture capital (VC) and tax expenditure programs - an international comparative analysis of legal structures and benefits. VC investment is an important catalyst for economic growth. Many governments, including the Australian government, have designed schemes to encourage VC investment. This project compares VC schemes that exist in OECD and ASEAN countries. It will focus on "tax expenditure programs" and will analyse their legal structures and benefits. The results will be used to benchmark Au ....Venture capital (VC) and tax expenditure programs - an international comparative analysis of legal structures and benefits. VC investment is an important catalyst for economic growth. Many governments, including the Australian government, have designed schemes to encourage VC investment. This project compares VC schemes that exist in OECD and ASEAN countries. It will focus on "tax expenditure programs" and will analyse their legal structures and benefits. The results will be used to benchmark Australia's main VC schemes - the "PDF program" and "VCLP scheme". The research is designed to discover insights into alternative ways of stimulating VC investment as well as suggest areas for potential law reform and structural change. Findings will be published in refereed journal articles and an independent report provided to the Australian Government.Read moreRead less
Protecting while they prosper? Organisational responses to whistleblowing. This project aims to examine the adequacy of organisational responses to whistleblowing (employee reporting of wrongdoing). So far, research into public-interest whistleblowing has revealed much about the incidence, significance and experience of whistleblowers. This project now extends the research to the other side of the issue — the organisations. By comparing employee and managerial experience in multiple public and p ....Protecting while they prosper? Organisational responses to whistleblowing. This project aims to examine the adequacy of organisational responses to whistleblowing (employee reporting of wrongdoing). So far, research into public-interest whistleblowing has revealed much about the incidence, significance and experience of whistleblowers. This project now extends the research to the other side of the issue — the organisations. By comparing employee and managerial experience in multiple public and private sector organisations in Australia and New Zealand, the project intends to identify the factors that influence good and bad responses across a range of institutions; provide a clearer basis for reform of policies, procedures and law; and set benchmarks for comparative research worldwide.Read moreRead less
Litigation and Liability as Regulation to Reduce Tobacco Related Harm. The new National Tobacco Strategy, signed in November 2004 by all Australian Governments, explains that successful tobacco control interventions bring major social and economic returns, including healthy and independent ageing, sustainable health care systems, a stronger economy, stronger communities, stronger families, improved indigenous health, and less harm from illicit drugs. The NTS acknowledges that regulation is a key ....Litigation and Liability as Regulation to Reduce Tobacco Related Harm. The new National Tobacco Strategy, signed in November 2004 by all Australian Governments, explains that successful tobacco control interventions bring major social and economic returns, including healthy and independent ageing, sustainable health care systems, a stronger economy, stronger communities, stronger families, improved indigenous health, and less harm from illicit drugs. The NTS acknowledges that regulation is a key tobacco control intervention. The research will explore and make recommendations about new regulatory approaches that have the capacity to substantially reduce the harm caused by tobacco, and to maximise the social and economic returns of tobacco control to the community. Read moreRead less