Improving the growth rate and flesh quality of cultured Barramundi: Investigating the effects of temperature, diet, and population. Barramundi fillet is one of the premier seafoods available in Australia and the decline of wild fisheries has increased the demand for the cultured product. Accordingly, there has been a rapid growth of the barramundi farming industry, but competition from cheaper overseas imports has cut the sale price and profit margins of local growers. By developing methods to i ....Improving the growth rate and flesh quality of cultured Barramundi: Investigating the effects of temperature, diet, and population. Barramundi fillet is one of the premier seafoods available in Australia and the decline of wild fisheries has increased the demand for the cultured product. Accordingly, there has been a rapid growth of the barramundi farming industry, but competition from cheaper overseas imports has cut the sale price and profit margins of local growers. By developing methods to increase growth rates, this research has the potential to substantially increase profit margins by reducing production costs and increasing turnover. Improvement of flesh quality will also increase the attractiveness of barramundi fillet. Increasing the viability of barramundi culture in Australia will attract more growers and increase employment opportunities.Read moreRead less
Evaluating the effects of fipronil, a moderately persistent new generation pesticide, on Australian native vertebrates. The Australian Plague Locust Commission is considering replacing an organophosphate pesticide with fipronil, a relatively new phenyl pyrazole pesticide, because it more specifically targets invertebrate animals. However, fipronil is more environmentally persistent, has high lipid solubility, is known to disrupt thyroid function and has wide variation in its toxicity to vertebra ....Evaluating the effects of fipronil, a moderately persistent new generation pesticide, on Australian native vertebrates. The Australian Plague Locust Commission is considering replacing an organophosphate pesticide with fipronil, a relatively new phenyl pyrazole pesticide, because it more specifically targets invertebrate animals. However, fipronil is more environmentally persistent, has high lipid solubility, is known to disrupt thyroid function and has wide variation in its toxicity to vertebrates . These characteristics place native vertebrate species at risk. Further, because peak locust activity is coincident with vertebrate breeding, there is likelihood that fipronil will affect development of young and the health of adults. We propose to launch the first comprehensive study of fipronil's effects on the health and vitality of native vertebrate adults and their offspring. We will focus on dasyurid marsupials and native birds that co-occur with plague locusts.Read moreRead less
The energetic basis to seed longevity and storage. The energetic basis to seed longevity and storage. This project aims to quantify patterns of metabolic rate in Australian native seeds to research seed ecology, dormancy, germination, longevity and persistence in natural and artificial seed banks. The project aims to optimise and refine current respirometry technology for use with native seeds, understand the allometric relationship and patterns with seed diversity, and apply this knowledge to b ....The energetic basis to seed longevity and storage. The energetic basis to seed longevity and storage. This project aims to quantify patterns of metabolic rate in Australian native seeds to research seed ecology, dormancy, germination, longevity and persistence in natural and artificial seed banks. The project aims to optimise and refine current respirometry technology for use with native seeds, understand the allometric relationship and patterns with seed diversity, and apply this knowledge to benefit restoration and conservation seed banks. By interpreting the energetics of seeds in a phylogenetic context, this project will develop an experimental protocol to predict the physiology and longevity, and test the viability of seeds in storage. Anticipated outcomes are improved efficiency of seed bank storage, conservation and restoration efforts.Read moreRead less
The preservation and management of Koala genetic diversity using reproductive biotechnology and molecular genetics: A model for endangered Australian marsupials. Assisted breeding technology will provide a new paradigm for solving problems associated with the preservation and management of captive and wild Koala populations. This project aims to improve methods of koala sperm cryopreservation and its subsequent use in artificial insemination and to establish a functional frozen sperm bank screen ....The preservation and management of Koala genetic diversity using reproductive biotechnology and molecular genetics: A model for endangered Australian marsupials. Assisted breeding technology will provide a new paradigm for solving problems associated with the preservation and management of captive and wild Koala populations. This project aims to improve methods of koala sperm cryopreservation and its subsequent use in artificial insemination and to establish a functional frozen sperm bank screened for the most prevalent pathogens. Important outcomes will include (1) a reliable, cost effective and disease free approach to the transfer of Koala genetic material into international and national zoos; (2) a technique for the management of free-range genetically restricted Koala populations and (3) successful cryostorage of Koala spermatozoa for the long-term maintenance of genetic potential.Read moreRead less
Digestive Physiology of Crocodilians: Towards an Improved Diet and Feeding Regime for Use by the Farming Industry. Crocodile farming promotes the sustainable production and consumption of crocodile products without harming natural populations. The industry grosses over $15 million per year in Australia and $200 million worldwide. Costs associated with transporting and storing food are the single largest expense that crocodile farms have. Increases in the efficiency of converting food into growth ....Digestive Physiology of Crocodilians: Towards an Improved Diet and Feeding Regime for Use by the Farming Industry. Crocodile farming promotes the sustainable production and consumption of crocodile products without harming natural populations. The industry grosses over $15 million per year in Australia and $200 million worldwide. Costs associated with transporting and storing food are the single largest expense that crocodile farms have. Increases in the efficiency of converting food into growth will have positive economic benefits to the industry. Efficiencies can be produced by (1) increasing food absorption, (2) decreasing the energetic costs of digestion, and (3) producing a new food that is less expensive to ship and store. This project will directly address the first two of these and will lay the foundation for the development of the third. Read moreRead less
Avoiding Environmental Bankruptcy: the grazing impacts of red kangaroos and sheep. Overgrazing is one of the most serious environmental and economic problems in Australia. By mitigating overgrazing, our project has three major benefits. Firstly, quantification of the foraging requirements for free-ranging sheep and kangaroos will, for the first time, allow us to identify sustainable practices that prevent overgrazing and contribute to significant land recovery. Secondly, a new mechanistic model ....Avoiding Environmental Bankruptcy: the grazing impacts of red kangaroos and sheep. Overgrazing is one of the most serious environmental and economic problems in Australia. By mitigating overgrazing, our project has three major benefits. Firstly, quantification of the foraging requirements for free-ranging sheep and kangaroos will, for the first time, allow us to identify sustainable practices that prevent overgrazing and contribute to significant land recovery. Secondly, a new mechanistic model for predicting herbivore dynamics will allow us to evaluate potential impacts of climate change on future grazing pressures. Thirdly, our results will inform management plans to sustain Australia's arid rangelands as productive, bio-diverse environments, which currently provide economic returns in excess of $20 billion p.a.Read moreRead less
Ecology, physiology and molecular microbiology of coral disease on the Great Barrier Reef. Ecological, physiological, molecular and micro-biological techniques will be used to examine the disease of corals of the Great Barrier Reef (GBR). Molecular techniques include the development of diagnostic techniques for disease identification, using Fluorescent In Situ hybridisation (FISH) and DNA microarrays (CHIPS); physiological experiments include examining the effects of temperature and sediment o ....Ecology, physiology and molecular microbiology of coral disease on the Great Barrier Reef. Ecological, physiological, molecular and micro-biological techniques will be used to examine the disease of corals of the Great Barrier Reef (GBR). Molecular techniques include the development of diagnostic techniques for disease identification, using Fluorescent In Situ hybridisation (FISH) and DNA microarrays (CHIPS); physiological experiments include examining the effects of temperature and sediment on virulence and host susceptibility to disease infection; ecological surveys will examine the extent and seasonality of disease in northern and southern parts of the GBR and on isolated reefs in the central GBR. Management implications of the current coral-disease status of the GBR will be targeted.Read moreRead less
Relaxin: molecular mechanisms of action in the reversal of fibrosis. Defects in relaxin and relaxin receptors are increasingly implicated as a cause of fibrosis which is associated with many disease processes. This study will examine the molecular mechanisms linking relaxin and fibrosis and will determine whether relaxin can be used to reverse the condition.
Relaxin action in the heart, kidney, lung and uterus: understanding fibrosis. Relaxin is a peptide hormone associated with pregnancy. We have recently generated a relaxin gene knockout mouse and exciting preliminary data show that without relaxin, non-pregnant mice develop signs of fibrosis in the heart, lung and uterus. Combining our expertise in molecular biology, pharmacology and physiology, the overall objective of this project is to investigate the functions and mechanisms of relaxin action ....Relaxin action in the heart, kidney, lung and uterus: understanding fibrosis. Relaxin is a peptide hormone associated with pregnancy. We have recently generated a relaxin gene knockout mouse and exciting preliminary data show that without relaxin, non-pregnant mice develop signs of fibrosis in the heart, lung and uterus. Combining our expertise in molecular biology, pharmacology and physiology, the overall objective of this project is to investigate the functions and mechanisms of relaxin action in these organs. Our findings will provide important basic information on relaxin physiology and enable us to implement a long-term partnership with Connetics to understand how relaxin regulates collagen production and/or the development of fibrosis.Read moreRead less
Electric field effects on cochlear tissues. The project aims to solve the underlying biology of how electricity flows through the cochlear tissues, where and how electrical stimulation excites the auditory neurons, and what the effects of sustained electrical stimulation are on the nerve fibre growth and function. The research aims to show how electric fields can be controlled in the cochlea, and how auditory nerve fibres are affected at the cellular and molecular level. The long-term aim is to ....Electric field effects on cochlear tissues. The project aims to solve the underlying biology of how electricity flows through the cochlear tissues, where and how electrical stimulation excites the auditory neurons, and what the effects of sustained electrical stimulation are on the nerve fibre growth and function. The research aims to show how electric fields can be controlled in the cochlea, and how auditory nerve fibres are affected at the cellular and molecular level. The long-term aim is to utilise these findings to improve the control of neuronal excitability, for development of interfaces with the nervous system.Read moreRead less