Novel Statistical Methods For Genetic Epidemiology
Funder
National Health and Medical Research Council
Funding Amount
$481,505.00
Summary
We are in the midst of a genomics revolution that is transforming epidemiology, medicine and drug discovery. However, the scarcity of sophisticated statistical techniques to deal with the complicated problems inherent in genetic investigations of complex diseases is currently the critical factor limiting the success of human gene discovery programs. Statistical genetic methodology is currently one of the fastest developing areas of epidemiology. In information-intensive' areas such as genetic ep ....We are in the midst of a genomics revolution that is transforming epidemiology, medicine and drug discovery. However, the scarcity of sophisticated statistical techniques to deal with the complicated problems inherent in genetic investigations of complex diseases is currently the critical factor limiting the success of human gene discovery programs. Statistical genetic methodology is currently one of the fastest developing areas of epidemiology. In information-intensive' areas such as genetic epidemiology, genomics, and proteomics, there is a high demand for data analysis and statistical skills. WA has some world class expertise in statistical science, both in academia and in industry. However, this expertise has not yet been applied in a system way to genetic data analysis. We propose to undertake advanced methodological research in statistical genetics and bioinformatics, to produce easy-to-use and accessible software tools and resources that allow methodological advances to be accessed by the Australian research community, and to apply our new methods and tools both to specific disease research and to the developing human genome epidemiology (HuGE) enterprise in WA. These new initiatives in methodological research will draw together a number of currently separate research strands and will provide new tools and resources that will allow applied Australian programs to improve the efficiency of their research into the causes of important. Methodological development in both bioinformatics and statistical genetics are recognized international areas of need.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100148
Funder
Australian Research Council
Funding Amount
$460,000.00
Summary
TrISMA - Tracking Infrastructure for Social Media Analysis. Tracking infrastructure for social media analysis: The tracking infrastructure for social media analysis (TrISMA) project establishes state-of-the-art technical and organisational infrastructure for the tracking of public communication by Australian users of social media, at large scale, in real time, and for the long term, addressing a significant gap in national research infrastructure. Social media are increasingly embedded in the Au ....TrISMA - Tracking Infrastructure for Social Media Analysis. Tracking infrastructure for social media analysis: The tracking infrastructure for social media analysis (TrISMA) project establishes state-of-the-art technical and organisational infrastructure for the tracking of public communication by Australian users of social media, at large scale, in real time, and for the long term, addressing a significant gap in national research infrastructure. Social media are increasingly embedded in the Australian media ecology, and systematic analyses of how public communication takes place via social media provide rich insights into a range of issues and debates of high importance to our society.Read moreRead less
A hand up: Disrupting the communication of intergenerational welfare dependency. Some families rely permanently on welfare support and communicate this dependency to the next generation. Children growing up in these families find it difficult to break out of poverty. With the help of twelve families and members of the St Vincent de Paul Society (Western Australia), this project aims to create ethnographies which illuminate turning points and opportunities for change. It will look to use creative ....A hand up: Disrupting the communication of intergenerational welfare dependency. Some families rely permanently on welfare support and communicate this dependency to the next generation. Children growing up in these families find it difficult to break out of poverty. With the help of twelve families and members of the St Vincent de Paul Society (Western Australia), this project aims to create ethnographies which illuminate turning points and opportunities for change. It will look to use creative and educational interventions to explore new ways of delivering services and disrupting the communication of welfare dependency. Ending inherited poverty is a significant step in helping individuals reach their potential and frees resources for people facing sudden hardship.Read moreRead less
An ethnographic investigation into the everyday work and communication cultures of public transport transit guards: reducing risk and injury. This research improves the safety of public transport for workers and passengers with flow-on benefits at local and national levels. The main health and safety risk transit guards face is attacks upon them, or injury incurred while intervening in assaults they witness. Conventional initiatives have not impacted greatly on injury rates but culture and commu ....An ethnographic investigation into the everyday work and communication cultures of public transport transit guards: reducing risk and injury. This research improves the safety of public transport for workers and passengers with flow-on benefits at local and national levels. The main health and safety risk transit guards face is attacks upon them, or injury incurred while intervening in assaults they witness. Conventional initiatives have not impacted greatly on injury rates but culture and communication change strategies offer potential ways forward. Strategies that reduce incidents confer clear community benefits and competitive advantage. Effective management of such challenges assists with the recruitment and retention of appropriate staff, improving profitability. Benefits include reduced costs of public transport, increased passenger load, and positive environmental impacts.Read moreRead less
Toddlers and tablets: exploring the risks and benefits 0-5s face online. Children aged between zero and five are experiencing an extraordinary shift in media consumption. They intuitively swipe screens and press buttons on tablet computers and smartphones, using apps and accessing the internet. With an estimated five-fold increase in their tablet usage (2012 to 2013), there is an urgent need for research and policy development to maximise benefit and minimise risk. This project is intended to in ....Toddlers and tablets: exploring the risks and benefits 0-5s face online. Children aged between zero and five are experiencing an extraordinary shift in media consumption. They intuitively swipe screens and press buttons on tablet computers and smartphones, using apps and accessing the internet. With an estimated five-fold increase in their tablet usage (2012 to 2013), there is an urgent need for research and policy development to maximise benefit and minimise risk. This project is intended to investigate family practices and attitudes around very young children's internet use in Australia and the United Kingdom, and is expected to contribute to public debate and evidence-based policy in Australia, the United Kingdom and Ireland. It aims to develop recommendations for policy makers and offers guidelines for parents of three age groups: zero to one, two to three and four to five.Read moreRead less
A Structural Investigation Into The T-cell Response To Epstein Barr Virus Infection
Funder
National Health and Medical Research Council
Funding Amount
$549,000.00
Summary
X-ray crystallography is an essential tool for solving the three-dimensional structure of proteins. Proteins control the biological processes within the cell and it is the precise shape of proteins that determines how they function. Depending on the particular sequence of the amino acids, the so-called building unit of the proteins, the protein molecule bends and forms a distinct, complex shape. This specific three-dimensional shape allows the protein to undertake its specific function, such as ....X-ray crystallography is an essential tool for solving the three-dimensional structure of proteins. Proteins control the biological processes within the cell and it is the precise shape of proteins that determines how they function. Depending on the particular sequence of the amino acids, the so-called building unit of the proteins, the protein molecule bends and forms a distinct, complex shape. This specific three-dimensional shape allows the protein to undertake its specific function, such as binding to other proteins, acting as an enzyme or interacting with nucleic acids. To determine how a protein acts, it is vital to know the precise three-dimensional shape at the atomic level. This proposal is concerned with understanding the precise shape of proteins that control the immune response to Epstein Barr Virus. Epstein Barr Virus is an ubiquitous human pathogen that has being linked to a number of cancers. This work will further our understanding of the immune response to Epstein Barr Virus.Read moreRead less
Structural relations of loners' loneliness and antisocial behaviour in children and adolescents: building a conceptual model for effective intervention. This is the first research project to develop a conceptual model of loneliness and detached a-loneness to explain the contribution of loneliness to childhood and adolescent antisocial behaviour. The outcome will be a school-based web delivered program which will have a major impact on promoting the healthy development of young Australians.
Young People, Technology, and Wellbeing Research Facility. Large numbers of initiatives now mobilise technology to support the wellbeing of young Australians. However, amongst communities undertaking this work, there is currently significant duplication and insufficient sharing of research and best practice models. A Research Facility that consolidates existing research, and guides new research and initiatives will improve service delivery to young Australians by: reducing duplication between or ....Young People, Technology, and Wellbeing Research Facility. Large numbers of initiatives now mobilise technology to support the wellbeing of young Australians. However, amongst communities undertaking this work, there is currently significant duplication and insufficient sharing of research and best practice models. A Research Facility that consolidates existing research, and guides new research and initiatives will improve service delivery to young Australians by: reducing duplication between organizations working with young people; providing an accessible interface with research that can help address the community’s concerns about the role of technology in young people’s lives, and inform future policy and programs; and model effective cross-sector knowledge brokering to Australian industry. Read moreRead less
Navigating urban spaces. This project aims to study how disabled people use smartphones to navigate the urban environment. Smartphones could improve urban accessibility and social participation for people with impairments. The project will study how this group uses smartphones to mitigate the effects of their impairments and compensate for inaccessibility in urban spaces. The study is expected to comprehensively map mobile phone use in urban space to inform design of the urban space, and the dev ....Navigating urban spaces. This project aims to study how disabled people use smartphones to navigate the urban environment. Smartphones could improve urban accessibility and social participation for people with impairments. The project will study how this group uses smartphones to mitigate the effects of their impairments and compensate for inaccessibility in urban spaces. The study is expected to comprehensively map mobile phone use in urban space to inform design of the urban space, and the development of apps as disabled people integrate with these spaces. This project intends to address wider problems related to the social participation of people with disability.Read moreRead less
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$14,927,045.00
Summary
This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune or inflammatory diseases.