Effect Of Sex Steroids, Inflammation, Environmental And Biopsychosocial Factors On Cardiometabolic Disease Risk In Men
Funder
National Health and Medical Research Council
Funding Amount
$1,817,271.00
Summary
Heart disease is more frequent and occurs at an earlier age in men than women. The reason is unknown. Apart from obesity and associated disturbances of metabolism, changes in sex hormones such as testosterone, together with the effects of inflammation may be important, and may in turn be affected by environment, lifestyle behaviours, and stress. To untangle these relationships, we will use cutting edge technology, in a large sample of men, in partnership with other international scientists.
CENTRE OF RESEARCH EXCELLENCE TO REDUCE INEQUALITY IN HEART DISEASE
Funder
National Health and Medical Research Council
Funding Amount
$2,607,253.00
Summary
There is increasing recognition of a societal responsibility to provide effective and sustainable health care to the entire population and not just to selected parts. Indigenous and regional Australians are most affected by Australia's biggest killer - heart disease. In response, the CRE to Reduce Inequality in Heart Disease, is a national collaboration of researchers from a range of health disciplines. Together they aim to address this problem by developing sustainable and cost-effective health ....There is increasing recognition of a societal responsibility to provide effective and sustainable health care to the entire population and not just to selected parts. Indigenous and regional Australians are most affected by Australia's biggest killer - heart disease. In response, the CRE to Reduce Inequality in Heart Disease, is a national collaboration of researchers from a range of health disciplines. Together they aim to address this problem by developing sustainable and cost-effective health care services.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883078
Funder
Australian Research Council
Funding Amount
$356,000.00
Summary
Liquid Chromatography Tandem Mass Spectrometry Steroid Analysis Facility. This first of a new generation of ultra-sensitive analytical mass spectrometers for small molecules will be established as a national assay facility allowing all Australian researchers open access to a new dimension of highly accurate and simultaneous measurements of multiple bodily chemicals such as steroids, vitamins and hormones. It is crucial to developing new knowledge in basic, developmental and pathological cell bio ....Liquid Chromatography Tandem Mass Spectrometry Steroid Analysis Facility. This first of a new generation of ultra-sensitive analytical mass spectrometers for small molecules will be established as a national assay facility allowing all Australian researchers open access to a new dimension of highly accurate and simultaneous measurements of multiple bodily chemicals such as steroids, vitamins and hormones. It is crucial to developing new knowledge in basic, developmental and pathological cell biology and for underpinning commercial developments of new molecular targets for therapeutic drugs for many diseases including cancer, cardiovascular disease and reproductive disorders. This facility is pivotal to maintaining international competitiveness in many areas of biological research in national priority areas.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668241
Funder
Australian Research Council
Funding Amount
$824,610.00
Summary
A Facility for High-Throughput, Functional Gene Discovery Using Arrayed Retroviral Expression Cloning. The proposed facility will represent world-leading technology in functional genomics and provide Australian scientists with unique opportunities to identify genes involved in a broad range of biological processes. This will contribute to fundamental knowledge in mammalian biology, and equally importantly, is likely to identify genes involved in important health problems such as cancer, inflamma ....A Facility for High-Throughput, Functional Gene Discovery Using Arrayed Retroviral Expression Cloning. The proposed facility will represent world-leading technology in functional genomics and provide Australian scientists with unique opportunities to identify genes involved in a broad range of biological processes. This will contribute to fundamental knowledge in mammalian biology, and equally importantly, is likely to identify genes involved in important health problems such as cancer, inflammatory disease, brain damage and diabetes. Such genes may in turn constitute targets against which new therapies may be developed. This endeavour will contribute to national research priorities in both the health and scientific/technological development arenas.Read moreRead less
Towards operational monitoring of key climate parameters from synthetic aperture radar. Agricultural productivity is a major contributor to the Australian economy, but is experiencing significant stress in response to climate change. Moreover, soil moisture controls vegetation dynamics that contribute to carbon storage, atmospheric processes leading to severe weather, and runoff generation processes leading to floods and runoff yield from urban water storage catchments. Consequently, high reso ....Towards operational monitoring of key climate parameters from synthetic aperture radar. Agricultural productivity is a major contributor to the Australian economy, but is experiencing significant stress in response to climate change. Moreover, soil moisture controls vegetation dynamics that contribute to carbon storage, atmospheric processes leading to severe weather, and runoff generation processes leading to floods and runoff yield from urban water storage catchments. Consequently, high resolution time-series information on soil moisture and vegetation status from space represents a powerful tool for understanding climate change impacts on Australia. It is therefore imperative that products be developed specifically for the Australian environment to take full advantage of radar data from satellites.Read moreRead less
Improving water quality modelling by better understanding solute transport. Poor stream water quality is a critical problem in Australia and globally. Stream water quality depends directly on pathways and time taken for water to transport pollutants through catchments. Predicting these pathways is highly challenging and currently requires specialised data. This project aims to better model the movement of water from rainfall to streams, enable greatly improved use of water quality data routinely ....Improving water quality modelling by better understanding solute transport. Poor stream water quality is a critical problem in Australia and globally. Stream water quality depends directly on pathways and time taken for water to transport pollutants through catchments. Predicting these pathways is highly challenging and currently requires specialised data. This project aims to better model the movement of water from rainfall to streams, enable greatly improved use of water quality data routinely collected in Australia's catchments and thereby better predict water quality behaviour. Proposed field studies aim to support this development. The outcomes sought are improved planning and management of water quality in our rivers, lakes and estuaries, improved health of these water bodies and improved water supplies.Read moreRead less
Reducing the deleterious impacts of clay particle interactions with valuable minerals in copper and gold processing. This project seeks to understand the rheological behaviour of clay minerals and the effect of the viscosity caused by clay minerals on gas dispersion, the transport of network structures and the locking of the structures in the froth in mineral flotation. Novel methods will be developed to improve flotation separation by reducing the viscosity.
Surface engineering of oriented nano-layers for performance control. This research project will deliver knowledge on how to graft oriented, self assembled films from a surface, develop structure-property relationships at a nano-scale, develop a means to control these properties and develop characterization techniques at nano-scales. This research project, if successful, will deliver the ability to tailor the properties of a surface in a manner and over a range of properties that is not even cont ....Surface engineering of oriented nano-layers for performance control. This research project will deliver knowledge on how to graft oriented, self assembled films from a surface, develop structure-property relationships at a nano-scale, develop a means to control these properties and develop characterization techniques at nano-scales. This research project, if successful, will deliver the ability to tailor the properties of a surface in a manner and over a range of properties that is not even contemplated today.
In addition to the scientific benefits, there are also immediate commercial applications in Australia and worldwide for ophthalmic products (e.g. anti-fog and easy to clean lenses), if the balance of properties can be obtained.
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Do root microbiomes control seagrass response to environmental stress? The project aims to determine the role root microbes play in controlling seagrass responses to environmental stress. By integrating marine and microbial ecology, environmental genomics and ecosystem function (e.g., biogeochemical cycling), this project is significant as it will create new knowledge of the processes that confer seagrass resilience to global environmental issues. An expected outcome is an increased understandin ....Do root microbiomes control seagrass response to environmental stress? The project aims to determine the role root microbes play in controlling seagrass responses to environmental stress. By integrating marine and microbial ecology, environmental genomics and ecosystem function (e.g., biogeochemical cycling), this project is significant as it will create new knowledge of the processes that confer seagrass resilience to global environmental issues. An expected outcome is an increased understanding of how microbes control seagrass health and an enhanced capacity to develop effective restoration strategies for Australia's valuable seagrass ecosystems. Benefits include improving the extensive environmental, economic, social/cultural services Australian communities derive from seagrass ecosystems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100220
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
A study of the bulk and surface responses of ores to high voltage pulses applied using a selFrag Lab. Minerals account for 40% of Australia's exports and mining is a major Australian employer. The health of the industry is integral to Australia's prosperity. Recent events have shown that mining cannot rely on high commodity prices but must continually seek efficiency improvements. This will be even more critical as production depends increasingly on low-grade ore deposits. Using selFrag Lab, ....A study of the bulk and surface responses of ores to high voltage pulses applied using a selFrag Lab. Minerals account for 40% of Australia's exports and mining is a major Australian employer. The health of the industry is integral to Australia's prosperity. Recent events have shown that mining cannot rely on high commodity prices but must continually seek efficiency improvements. This will be even more critical as production depends increasingly on low-grade ore deposits. Using selFrag Lab, the response of different ores to high voltage pulses will be studied to identify processes that liberate a greater percentage of valuable minerals while using less energy and less water and keeping toxic elements bound in larger waste particles. SelFrag-based research will therefore deliver major economic and environmental benefits to Australia.Read moreRead less