Preclinical Evaluation Of A Novel Allosteric IL-1R Inhibitor (rytvela) For The Prevention Of Perinatal Inflammation-induced Fetal Injury
Funder
National Health and Medical Research Council
Funding Amount
$1,377,827.00
Summary
Interleukin-1 (IL-1) is a potent inflammatory protein involved in many inflammatory disorders, including preterm birth (PTB). Blocking the actions of IL-1 in pregnancies at risk of delivering preterm may protect the fetus from PTB and the long-term harm of exposure to inflammation before birth. Using four different models of antenatal inflammation, we will explore the use of a new IL-1 inhibitor to see if it blocks inflammation ‘in utero’ and improve neonatal health and development.
Peri-conception Determinants Of Reproductive And Pregnancy Health
Funder
National Health and Medical Research Council
Funding Amount
$3,560,520.00
Summary
Reproductive and pregnancy disorders are common in Australian men and women, with 6% couples seeking infertility services and another 30% experiencing recurrent miscarriage, preeclampsia or preterm birth, often resulting in life-time health problems for children, and sometimes stillbirth. This research will investigate the immune causes of these conditions, and the results will contribute to new health tools, diagnostics and medical treatments to support maternal and infant health.
Predicting Renal, Ophthalmic, And Heart Events In The Aboriginal Community – THE PROPHECY Study
Funder
National Health and Medical Research Council
Funding Amount
$2,574,486.00
Summary
Up to 30% of adult Aboriginal people have diabetes yet our knowledge of the causes and predictors of complications remain incomplete. We have established the PROPHECY Study to assess the levels of complications in Aboriginal people with diabetes; to understand the way that these complications occur, and identify what clinical, social and genetic factors could predict who will get those complications to guide clinical management and prevention.
The Award Safety Net of the Australian Industrial Relations Commission. The industrial relations changes of the 1990s have altered the role of the Australian Industrial Relations Commission (AIRC) in prescribing and influencing the terms of employment. Its awards are now characterised as a ?safety net? and have, to a significant extent, been displaced by registered agreements as the legal instruments binding employers and employees. The project focuses on the remaining role of the safety net. Wh ....The Award Safety Net of the Australian Industrial Relations Commission. The industrial relations changes of the 1990s have altered the role of the Australian Industrial Relations Commission (AIRC) in prescribing and influencing the terms of employment. Its awards are now characterised as a ?safety net? and have, to a significant extent, been displaced by registered agreements as the legal instruments binding employers and employees. The project focuses on the remaining role of the safety net. What are its purposes? What are the criteria by which it is adjusted? What are the effects of the adjustments on actual wages, incomes and employment? How does the safety net relate to social welfare policies?Read moreRead less
The Allocation of Risk and Economic Slumps. The aim of this project is to construct and analyse models that identify a novel feedback mechanism in which the distribution of investment risk interacts with aggregate employment variations. It will provide a useable framework for economic policy analysis in which the distribution of wealth affects the demand for investment risk while the distribution of production risk affects the supply of labour income risk.
Radiostereometric Analysis Of The Effect Of A Large Articulation On Prosthetic Wear And Migration After Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$192,186.00
Summary
At total hip replacement, there has been a recent trend to use prostheses with a larger ball and liner in the socket. This may decrease the risk of post-operative dislocation, but may also increase the amount of wear, leading to bone loss and loosening of prostheses, which may then require replacement. This project will use a special type of x-ray to determine whether wear and movement of these new prostheses is clinically acceptable, so that they can be used with confidence in patients.
The Risks And Benefits Of Contemporary Total Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$493,530.00
Summary
The number of hip replacements undertaken in Australia is steadily increasing. The most common complications of hip replacements are dislocation and loosening due to bone loss around the implant, requiring complex and expensive revision surgery. This study will investigate the incidence of dislocation and, using a new diagnostic imaging technique, the incidence and amount of bone loss around a relatively new prosthetic material, the outcomes of which are not known despite its increasing use.
Achieving a Skilled and Sustainable Aged Care Workforce for Australia. Demand for aged care services in Australia has reached record levels and is set to rise steeply due to population ageing. The Productivity Commission identified the sector’s need to provide more care services, to expand consumer-directed care and to improve the quality of care. Currently, there is little evidence as to how the workforce can expand and change to meet these challenges. This project aims to provide new evidence ....Achieving a Skilled and Sustainable Aged Care Workforce for Australia. Demand for aged care services in Australia has reached record levels and is set to rise steeply due to population ageing. The Productivity Commission identified the sector’s need to provide more care services, to expand consumer-directed care and to improve the quality of care. Currently, there is little evidence as to how the workforce can expand and change to meet these challenges. This project aims to provide new evidence on how to attract, retain and up-skill workers in a rapidly expanding demand environment, as the sector strives to achieve a sustainable and skilled workforce fit for the future needs of older Australians.Read moreRead less
A Genome-wide Association Scan To Identify Genetic Risk Factors For Sight Threatening Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$982,203.00
Summary
Diabetic eye disease is an important complication of diabetes that can lead to blindness. Very little is known about how diabetes causes eye disease, but genetics is known to play a role. We aim to identify genes that contribute to eye disease in diabetes patients. We will compare genes between patients with diabetes with and without severe diabetic eye disease using cutting edge genomic technology. We hope to be able to better predict risk of blindness and to move towards novel treatments.
Predicting Renal, Ophthalmic And Heart Events In The Aboriginal Community: The PROPHECY Diabetes Multi-Omics Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$3,955,505.00
Summary
Diabetes is at epidemic levels in Indigenous Australians, impairing quality of life, and contributing to poor health. This is a result of rapid development of kidney, heart and eye complications. We have established a large long-term population study among Aboriginal communities within South Australia and will explore the burden, natural history and the social, psychological, environmental, clinical and genomic predictors of diabetes and its complications.