Mechanical modulation of particle-cell interactions. Mechanical forces play critical roles in many biological processes, but how particle mechanical properties modulate particle-cell interactions remains elusive. This project aims to develop new design principles for engineering nano/micromaterials with tunable mechanical properties for improved cell activation and expansion, and to advance knowledge of the role of particle stiffness in modulating receptor-mediated particle-cell interactions. Ex ....Mechanical modulation of particle-cell interactions. Mechanical forces play critical roles in many biological processes, but how particle mechanical properties modulate particle-cell interactions remains elusive. This project aims to develop new design principles for engineering nano/micromaterials with tunable mechanical properties for improved cell activation and expansion, and to advance knowledge of the role of particle stiffness in modulating receptor-mediated particle-cell interactions. Expected outcomes and benefits include new fundamental understanding of the effect of particle mechanical properties on cell function, new insights into T cell activation and expansion, and new classes of stiffness-tunable fit-for-purpose materials for various applications in cell manufacturing.Read moreRead less
Engineering defect-intensive ozonation catalysts to degrade micropollutants. This project aims to engineer unique particles containing defect-intensive surfaces which are designed to accelerate the catalytic ozonation of waters contaminated with pharmaceuticals and other recalcitrant pollutants. This will enable timely treatment of industrial waste water as well as sewerage treatment plant effluents using simple and cheap catalyst materials. Wet- and flame-based particle fabrication technologies ....Engineering defect-intensive ozonation catalysts to degrade micropollutants. This project aims to engineer unique particles containing defect-intensive surfaces which are designed to accelerate the catalytic ozonation of waters contaminated with pharmaceuticals and other recalcitrant pollutants. This will enable timely treatment of industrial waste water as well as sewerage treatment plant effluents using simple and cheap catalyst materials. Wet- and flame-based particle fabrication technologies paired with unique post-synthesis treatment strategies, including either a coupled hydrogenation-illumination approach or plasma exposure, will be implemented for defect manipulation so as to produce new cheaper, stable, and higher-performing catalysts for activating ozone to treat water containing pharmaceutical and endocrine disrupting micro-pollutants under different process conditions.Read moreRead less