Antibiotic resistance is a looming public health crisis. New antibiotics with new mechanisms of action are desperately needed. The long-term goal of this research is to develop new drugs that disarm bacteria to overcome the problem of antibiotic resistance.
Discovery Early Career Researcher Award - Grant ID: DE130101183
Funder
Australian Research Council
Funding Amount
$361,880.00
Summary
Next-generation expanders for renewable power applications: dealing with variability and uncertainty. This project will develop new strategies to design optimum expanders capable of maintaining good performance under uncontrollable working conditions. If these innovative design methods can be applied to engineering applications they will assist Australia to meet the Renewable Energy Target and to become an international leader in the field.
Theoretical modelling and design of safe covalent anti-cancer drugs. Covalent drugs are a new class of drugs with outstanding potential in cancer therapy. Detailed computer modelling studies will be performed to determine how these drugs interact with an important target in cancer therapy, the epithelial growth factor receptor, and thereby aid the development of new cancer treatments.
Enhanced force fields for computational drug design and materials research. This project aims to improve the atomic interaction functions used to calculate the structural, dynamic and thermodynamic properties of molecules that alter net charge or structure in different environments. Predicting the stability of alternative protonation and tautomeric states for molecules bound to therapeutic targets is a major challenge in computational drug design. It is key to identifying the therapeutically act ....Enhanced force fields for computational drug design and materials research. This project aims to improve the atomic interaction functions used to calculate the structural, dynamic and thermodynamic properties of molecules that alter net charge or structure in different environments. Predicting the stability of alternative protonation and tautomeric states for molecules bound to therapeutic targets is a major challenge in computational drug design. It is key to identifying the therapeutically active chemical species as well as understanding drug transport and off-target effects. The work will expand the utility of modelling software used by over 13,000 researchers worldwide. In addition, the improved interaction functions will also help in the understanding of a wide range of other materials at an atomic level.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101546
Funder
Australian Research Council
Funding Amount
$288,900.00
Summary
Development of computer-based optimisation to improve hypersonic aerodynamic design. Next-generation launch vehicles using high-speed jet engines will make it cheaper and more reliable for humankind to engage in activities in space. This project will contribute to the technology of high-speed jet engines by developing optimised air intake systems. The research aims to advance the use of computational engineering and apply this to improve the design of air intake systems. The outcomes of this pro ....Development of computer-based optimisation to improve hypersonic aerodynamic design. Next-generation launch vehicles using high-speed jet engines will make it cheaper and more reliable for humankind to engage in activities in space. This project will contribute to the technology of high-speed jet engines by developing optimised air intake systems. The research aims to advance the use of computational engineering and apply this to improve the design of air intake systems. The outcomes of this project will advance the technology of high-speed jet engines with the goal of replacing existing rocket systems.Read moreRead less
Integrating architectural, mathematical and computing knowledge to capture the dynamics of air in design. This research will bring together architectural, mathematical and computing knowledge to discover effective ways to design buildings and cities that are more responsive to the complex dynamics of air movement and temperature. This knowledge will lead to reduced energy consumption and carbon dioxide emissions, increased comfort and more usable public space.
Elucidating the morphology of organic semiconductors at an atomic level. Controlling morphology and self-organization at a molecular level is key to advancing the performance of optoelectronic devices such as organic light-emitting diodes and organic photovoltaic cells. Current device development relies on a costly and inefficient empirical design cycle (material synthesis followed by device fabrication and testing). In addition, the active layers often involve multiple components and their nano ....Elucidating the morphology of organic semiconductors at an atomic level. Controlling morphology and self-organization at a molecular level is key to advancing the performance of optoelectronic devices such as organic light-emitting diodes and organic photovoltaic cells. Current device development relies on a costly and inefficient empirical design cycle (material synthesis followed by device fabrication and testing). In addition, the active layers often involve multiple components and their nano-scale morphology is difficult to probe experimentally. Recently developed molecular simulation techniques can provide unique insight into atomic-level structural details that determine device efficiency. The project will determine if such simulations are sufficiently accurate to be industrially useful.Read moreRead less
Centre Of Research Excellence In Medicines Intelligence
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
The NHMRC Centre of Research Excellence in Medicines Intelligence is a co-ordinated research program that will accelerate the development and translation of evidence on prescribed medicines use and outcomes for regulators and payers. The CRE is perfectly placed to embrace the national ‘call to action’ from the Health Minister's recent announcement to establish Quality Use of Medicine Safety as a National Health Priority.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100130
Funder
Australian Research Council
Funding Amount
$320,000.00
Summary
An earthquake shaking table to investigate soil-structure interactions. An earthquake shaking table to investigate soil-structure interactions: This project aims to develop Australia's most advanced earthquake shaking table. Earthquakes are a problem of great significance to Australia. Infrastructure in civil, transport, mining and energy sectors may be at an unacceptable risk of damage under earthquake loading as current design practices do not account for the interaction between infrastructure ....An earthquake shaking table to investigate soil-structure interactions. An earthquake shaking table to investigate soil-structure interactions: This project aims to develop Australia's most advanced earthquake shaking table. Earthquakes are a problem of great significance to Australia. Infrastructure in civil, transport, mining and energy sectors may be at an unacceptable risk of damage under earthquake loading as current design practices do not account for the interaction between infrastructure and the ground under such loading. The shaking table will simulate earthquakes and enable controlled testing of three-tonne models of foundation and soil-structure interaction systems typical of Australia's infrastructure. The discoveries made are expected to be integral to the modernisation of Australia's seismic design standards so that earthquake-induced damage and risk exposure can be minimised.Read moreRead less
Life Cycle Measures of Cost Effectiveness for 4 D CAD in Design and Construct Projects across Industry Sectors. The effective and efficient delivery of complex construction projects will be transformed by the increased application of virtual design and construction technologies, including 4D CAD. By combining a 3D computer model of a design with the time dimension of the construction schedule, 4D CAD enables risks and opportunities to be better managed during the design phase and hence avoid co ....Life Cycle Measures of Cost Effectiveness for 4 D CAD in Design and Construct Projects across Industry Sectors. The effective and efficient delivery of complex construction projects will be transformed by the increased application of virtual design and construction technologies, including 4D CAD. By combining a 3D computer model of a design with the time dimension of the construction schedule, 4D CAD enables risks and opportunities to be better managed during the design phase and hence avoid costly issues during construction. However this requires addition design costs which currently represent a barrier to the uptake of this transforming technology. This project will overcome this by developing a flexible framework that allows the benefits gained across the life cycle of a project through using 4D CAD to be set against the additional costs and thus make this emerging technology more attractive to industry. Significantly this research will be based on comparative cases studies across different industry sectors including civil, building, and process engineering.Read moreRead less