Understanding prokaryotic small proteins from context. Prokaryotic small proteins are increasingly recognised to play important biological roles but have been largely overlooked due to the lack of adequate tools to study them. This project aims to develop new methods to identify and predict the functions of small proteins from microbial communities by studying sequence patterns in their genomes. These predicted functions will be confirmed in the laboratory, leading to a catalogue of newly charac ....Understanding prokaryotic small proteins from context. Prokaryotic small proteins are increasingly recognised to play important biological roles but have been largely overlooked due to the lack of adequate tools to study them. This project aims to develop new methods to identify and predict the functions of small proteins from microbial communities by studying sequence patterns in their genomes. These predicted functions will be confirmed in the laboratory, leading to a catalogue of newly characterised small proteins from a diverse range of habitats and geographies. By creating new ways to study the role of small proteins in the global microbiome, we will provide the foundational knowledge required to leverage these proteins for use in biotechnology. Read moreRead less
Statistical Methods for Next Generation Genome-Wide Association Studies. This project aims to develop cutting-edge statistical methods to analyse large genomic datasets and identify genetic variants associated with inter-individual differences in various human traits. Knowledge of trait-associated DNA variants is instrumental in understanding how natural selection has shaped human traits. By integrating genomic data from diverse and underrepresented populations, this project further expects to c ....Statistical Methods for Next Generation Genome-Wide Association Studies. This project aims to develop cutting-edge statistical methods to analyse large genomic datasets and identify genetic variants associated with inter-individual differences in various human traits. Knowledge of trait-associated DNA variants is instrumental in understanding how natural selection has shaped human traits. By integrating genomic data from diverse and underrepresented populations, this project further expects to contribute to the equitable use of genomic technologies in humans, regardless of geographical origins. Expected outcomes of this research include novel analysis methods and software tools, which should broadly and significantly benefit gene discovery in other species, including those of agricultural relevance.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100883
Funder
Australian Research Council
Funding Amount
$452,777.00
Summary
The cognitive science of farsighted deliberation. Many fundamental decisions in life require us to deliberate about sooner versus later consequences. This cognitive psychology project aims to determine how the capacities that enable people to think about the future (prospection) and reflect on their own thinking (metacognition) influence how they manage such decisions. By using innovative methods, this project is expected to advance our understanding of future-oriented cognition across the lifes ....The cognitive science of farsighted deliberation. Many fundamental decisions in life require us to deliberate about sooner versus later consequences. This cognitive psychology project aims to determine how the capacities that enable people to think about the future (prospection) and reflect on their own thinking (metacognition) influence how they manage such decisions. By using innovative methods, this project is expected to advance our understanding of future-oriented cognition across the lifespan. Expected outcomes include new knowledge about how people deliberate through important everyday decisions. This should provide significant benefits by laying the foundation for improving effective choices about the future.Read moreRead less
Novel framework for optimising battery-cooling microchannel heat exchangers. Thermal overheating can affect the capacity, safety and life expectancy of batteries for renewable energy storage and electric vehicles. Microscale heat exchangers are a potential high-efficiency, low-bulk solution. This project aims to develop a novel computational methodology to optimise the design of those heat exchangers in which viscoelastic fluids are used to control flow instabilities and enhance heat transfer at ....Novel framework for optimising battery-cooling microchannel heat exchangers. Thermal overheating can affect the capacity, safety and life expectancy of batteries for renewable energy storage and electric vehicles. Microscale heat exchangers are a potential high-efficiency, low-bulk solution. This project aims to develop a novel computational methodology to optimise the design of those heat exchangers in which viscoelastic fluids are used to control flow instabilities and enhance heat transfer at the microscale. A new microscopic fluid physics model will provide data for an innovative neural network framework to optimise the working fluid conditions and microscale design, which could contribute to increased adoption of renewable energy technologies that are supported by microscale heat exchangers.Read moreRead less
Expanding the scramjet operating envelope through oxygen enrichment. This project aims to investigate the benefits of expanding the operating envelope of scramjets to higher altitudes and speeds by enriching their fuel with oxygen. This is expected to enhance the performance and flexibility of hypersonic air-breathing engines designed to form the core of a more reliable and economical access to space system. Expected outcomes of this project are a validated understanding and mapping of how oxyge ....Expanding the scramjet operating envelope through oxygen enrichment. This project aims to investigate the benefits of expanding the operating envelope of scramjets to higher altitudes and speeds by enriching their fuel with oxygen. This is expected to enhance the performance and flexibility of hypersonic air-breathing engines designed to form the core of a more reliable and economical access to space system. Expected outcomes of this project are a validated understanding and mapping of how oxygen enrichment can augment scramjet thrust at high altitudes and speeds, and a performance evaluation of a launch system optimised for this approach. This could provide significant benefits to the performance of reusable, air-breathing launch technology, where Australia is leading the push towards commercialisation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100794
Funder
Australian Research Council
Funding Amount
$419,000.00
Summary
Prediction of new electrolytes for improved electrical energy storage. This project aims to identify new electrolyte solutions with suitable properties for use in improved electrical energy storage technologies. Identifying new electrolyte solutions is a crucial challenge for improving the performance of many technologies including energy storage. This project applies quantum mechanical calculation to develop a fast, accurate and predictive model of the properties of electrolyte solutions. High ....Prediction of new electrolytes for improved electrical energy storage. This project aims to identify new electrolyte solutions with suitable properties for use in improved electrical energy storage technologies. Identifying new electrolyte solutions is a crucial challenge for improving the performance of many technologies including energy storage. This project applies quantum mechanical calculation to develop a fast, accurate and predictive model of the properties of electrolyte solutions. High throughput computational screening based on this model can then identify new electrolytes that can be used in technologies such as energy storage. This should give Australia a competitive edge in the rapidly growing energy storage industry, while also accelerating the shift away from harmful fossil fuels. Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100263
Funder
Australian Research Council
Funding Amount
$477,037.00
Summary
Improve genomic testing tools for fertility traits in beef cattle. Fertility is a key driver of productivity and profitability for beef industry; however, a substantial industry challenge is poor fertility and the difficulty and expense of measuring fertility in remote Australia. By integrating multiple omics datasets and fifty thousand fertility phenotypes recorded on beef cattle, the project will identify sequence variation, including structural variants, that underpin genetic variation in cat ....Improve genomic testing tools for fertility traits in beef cattle. Fertility is a key driver of productivity and profitability for beef industry; however, a substantial industry challenge is poor fertility and the difficulty and expense of measuring fertility in remote Australia. By integrating multiple omics datasets and fifty thousand fertility phenotypes recorded on beef cattle, the project will identify sequence variation, including structural variants, that underpin genetic variation in cattle fertility. Our industry partner, which genotypes hundreds of thousands of cattle a year, will produce new genotype arrays and novel low-cost sequencing approaches including these variants, enabling selection that could potentially increase herd reproductive rate by 4%, returning $40M per annum to the farmers.Read moreRead less
Design and verification of correct, efficient and secure concurrent systems. This project aims to provide methods for the design and verification of correct, secure and efficient concurrent software that are scalable and mechanised. Computers with multiple processors are now the norm and are used in a wide range of safety, security and mission critical software applications such as transport, health and infrastructure. These multi-core architectures have the potential to lead to important effici ....Design and verification of correct, efficient and secure concurrent systems. This project aims to provide methods for the design and verification of correct, secure and efficient concurrent software that are scalable and mechanised. Computers with multiple processors are now the norm and are used in a wide range of safety, security and mission critical software applications such as transport, health and infrastructure. These multi-core architectures have the potential to lead to important efficiency gains, but can introduce complex and error-prone behaviours that cannot be managed using traditional software development approaches. This project will produce better, scalable and mechanised methods for the design and verification of such software which is expected to reduce the prevalence of failures in efficient, modern software.Read moreRead less
Electron Transpiration Cooling of Hypersonic Vehicles. Future aircraft for flight at hypersonic speeds require sharp leading edges for the best aerodynamic performance. Sharp leading edges incur high heat loads and cannot be adequately cooled with current technologies. The project aim is to investigate novel surface materials that emit electrons when heated. This emission of electrons from the surface can significantly contribute to the cooling of the sharp leading edges. This project is expecte ....Electron Transpiration Cooling of Hypersonic Vehicles. Future aircraft for flight at hypersonic speeds require sharp leading edges for the best aerodynamic performance. Sharp leading edges incur high heat loads and cannot be adequately cooled with current technologies. The project aim is to investigate novel surface materials that emit electrons when heated. This emission of electrons from the surface can significantly contribute to the cooling of the sharp leading edges. This project is expected to deliver new experimental data on novel surface materials exposed to a hypersonic flow environment and computer models that can simulate their cooling effect. This investigation will contribute towards enabling technologies for sustained hypersonic flight by overcoming critical head load limitations.Read moreRead less