Optimising experimental design for robust product development: a case study for high-efficiency energy generation. This project tackles key mathematical challenges to provide a powerful new methodology and tool for optimal product design, making smarter use of limited information, minimising costly trials, shortening the product cycle, and boosting the competitiveness of both the Australian manufacturing and alternative energy production industries.
Using Advances in Bayesian Statistics to Estimate Australian Rainfall Variations in a Climate Change World. Modelling changes to rainfall patterns answers many important questions about changes in Australia's climate. This is essential to protecting our biodiversity and ensuring Australia's environmental sustainability. The project will address such issues as the extent to which the entire distribution of daily rainfall has changed over time, which areas of Australia have been most affected by t ....Using Advances in Bayesian Statistics to Estimate Australian Rainfall Variations in a Climate Change World. Modelling changes to rainfall patterns answers many important questions about changes in Australia's climate. This is essential to protecting our biodiversity and ensuring Australia's environmental sustainability. The project will address such issues as the extent to which the entire distribution of daily rainfall has changed over time, which areas of Australia have been most affected by this change and to what extent are these changes related to global climate indices. The latest advances in Bayesian statistics will be used to introduce flexibility and complexity into the model.Read moreRead less
Bayesian estimation of flexible spatial models with applications in medical imaging and econometric modeling. This project aims to develop statistical methodology for estimating flexible highly parameterised Bayesian spatial models. The flexible models examined will include regression, choice and time series models for data that is spatially registered. Spatial smoothing of parameters in the models will involve application of hierarchical spatial prior distributions. The resulting methodology wi ....Bayesian estimation of flexible spatial models with applications in medical imaging and econometric modeling. This project aims to develop statistical methodology for estimating flexible highly parameterised Bayesian spatial models. The flexible models examined will include regression, choice and time series models for data that is spatially registered. Spatial smoothing of parameters in the models will involve application of hierarchical spatial prior distributions. The resulting methodology will be applied to the analysis of medical imaging data and to the estimation of spatial econometric models of residential real estate prices. The expected outcomes include developments in the frontier framework of Bayesian computational estimation methodology, improved methods for medical image processing and estimation of high resolution spatial models of residential real estate prices in Australian metropolitan centres.Read moreRead less
Constrained and Stable Solutions of Nonlinear and Semismooth Equations. In this project, comprehensive models for designing safe power system parameters will be proposed, efficient algorthms for solving these models will be constructed. The new models and algorithms in this project will provide efficient tools to prevent catastrophic events in power systems, which is related with national security. This project will also strengthen collaboration of Australian applied
mathematians with inter ....Constrained and Stable Solutions of Nonlinear and Semismooth Equations. In this project, comprehensive models for designing safe power system parameters will be proposed, efficient algorthms for solving these models will be constructed. The new models and algorithms in this project will provide efficient tools to prevent catastrophic events in power systems, which is related with national security. This project will also strengthen collaboration of Australian applied
mathematians with international researchers and engineering scientists. This is important for the advance of science and technology in
Australia.Read moreRead less
Response of Proteins to External Non-Ionising Radiation: an Experimental and Computer Modelling Investigation. The expanding use of digital technologies such as mobile phones has led to major health concerns about the effects of non-ionising pulsed radiation exposure which has been shown to produce instantaneous temperature rises undetectable by normal thermometry. The health implications of exposure are not understandable without establishing molecular mechanisms by which pulsed microwaves can ....Response of Proteins to External Non-Ionising Radiation: an Experimental and Computer Modelling Investigation. The expanding use of digital technologies such as mobile phones has led to major health concerns about the effects of non-ionising pulsed radiation exposure which has been shown to produce instantaneous temperature rises undetectable by normal thermometry. The health implications of exposure are not understandable without establishing molecular mechanisms by which pulsed microwaves can cause biological effects. We aim to establish methods for studying the molecular mechanisms of protein structural and energetic changes occurring due to non-ionising radiation. The results will help our industry partner to design specific drugs as well as formulate a scientifically based standard for microwave utilisation.Read moreRead less
Electromechanical controls of membrane transport phenomena. This joint computational-experimental project will explain transport processes carried out by biological membranes under different physiological and pharmacological conditions, to understand the actions of viruses, toxins, antimicrobial peptides and membrane proteins, for novel therapeutics, drug delivery and bio-sensing applications.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989506
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
A high performance computing cluster and storage for the INTERSECT Consortium of NSW. The installation of this new supercomputing facility is an important addition to the nation's foundation research infrastructure. Of particular importance to research groups in NSW is the much needed boost in computational research and research training capacity that it will provide, enabling world leading research teams to continue their ground breaking work in an increasingly competitive international enviro ....A high performance computing cluster and storage for the INTERSECT Consortium of NSW. The installation of this new supercomputing facility is an important addition to the nation's foundation research infrastructure. Of particular importance to research groups in NSW is the much needed boost in computational research and research training capacity that it will provide, enabling world leading research teams to continue their ground breaking work in an increasingly competitive international environment. Much of the research to be supported lies in areas of national priority, including frontier technologies and Australian environmental sustainability.Read moreRead less
Rates, Patterns And Determinants Of Alcohol’s Harm To Others: A Cross-national Comparative Study
Funder
National Health and Medical Research Council
Funding Amount
$305,856.00
Summary
Alcohol causes harms to drinkers, and others around them, including spouses, children, family, friends, workmates and strangers. Australian and New Zealand work on alcohol’s harm to others is being replicated by the WHO in 7 countries (Chile, Nigeria, Sri Lanka, India, Thailand, Laos and Vietnam). We aim to analyse datasets from nine countries and compare the magnitude and patterning of problems across and within cultures – identifying opportunities for reducing harm from others’ drinking.
Overseeing the internet: new paradigms of network measurement. Like the electricity network, the internet is a core infrastructure, and so must be reliable and efficient. A gap in bandwidth supply is like a blackout in terms of lost business and productivity. This project will provide the measurement breakthroughs to ensure that network behaviour can be accurately and comprehensively monitored.
From Brain Maps To Mechanisms: Modeling The Pathophysiology Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
My Fellowship will develop a framework that integrates brain imaging data with mathematical models of the brain to help understand the mechanisms responsible for schizophrenia. By linking functional Magnetic Resonance Imaging (fMRI) measurements to models of their underlying causes, the work may lead to new treatments that target the specific dysfunction in individuals with this debilitating brain disorder.