Controlling ultracold atomic gases. This project will develop ways to control the quantum state of ultracold atomic gases. These experimentally accessible systems will be used to investigate and understand a huge range of scientific phenomena from stars to superconductors, and enable critical quantum technologies that will revolutionise communications and precision measurement.
The systems biology of stem cells. Using new bioinformatic methods, this project aims to identify new classifiers of different stem cell populations, develop statistical models that address population heterogeneity and provide molecular predictors of the differentiation potential of stem cells. Understanding, predicting and directing the processes of differentiation are major goals in the disciplines of stem cell biology, developmental biology, tissue engineering and regenerative medicine. Molec ....The systems biology of stem cells. Using new bioinformatic methods, this project aims to identify new classifiers of different stem cell populations, develop statistical models that address population heterogeneity and provide molecular predictors of the differentiation potential of stem cells. Understanding, predicting and directing the processes of differentiation are major goals in the disciplines of stem cell biology, developmental biology, tissue engineering and regenerative medicine. Molecular atlas projects have successfully revealed rules of genome output and regulation, by mining patterns that are evident across multiple cell types and datasets. By applying this philosophy to relevant, well-curated stem cell experiments, this project aims to create new methods for the integration and interrogation of smaller individual datasets. These methods should have broad utility and enable new avenues in tissue engineering.Read moreRead less
Developing bioinformatics methods for single cell transcriptomics. This project aims to develop novel bioinformatics methods for single cell transcriptomic data that seek to model variability in cell populations. The project expects to generate new approaches using Bayesian statistics that will act as high-end enablers of discovery in transcriptional regulatory processes. Through an interdisciplinary combination of experimental and computational research, insights into fundamental biological pro ....Developing bioinformatics methods for single cell transcriptomics. This project aims to develop novel bioinformatics methods for single cell transcriptomic data that seek to model variability in cell populations. The project expects to generate new approaches using Bayesian statistics that will act as high-end enablers of discovery in transcriptional regulatory processes. Through an interdisciplinary combination of experimental and computational research, insights into fundamental biological processes will be elucidated, specifically the robustness of cellular systems. Expected outcomes include a suite of novel tools that will push the boundaries of current bioinformatics solutions with potential to deliver significant benefits to every domain of biological science, particularly tissue engineering and synthetic biology.Read moreRead less
Statistical Methods for Next Generation Genome-Wide Association Studies. This project aims to develop cutting-edge statistical methods to analyse large genomic datasets and identify genetic variants associated with inter-individual differences in various human traits. Knowledge of trait-associated DNA variants is instrumental in understanding how natural selection has shaped human traits. By integrating genomic data from diverse and underrepresented populations, this project further expects to c ....Statistical Methods for Next Generation Genome-Wide Association Studies. This project aims to develop cutting-edge statistical methods to analyse large genomic datasets and identify genetic variants associated with inter-individual differences in various human traits. Knowledge of trait-associated DNA variants is instrumental in understanding how natural selection has shaped human traits. By integrating genomic data from diverse and underrepresented populations, this project further expects to contribute to the equitable use of genomic technologies in humans, regardless of geographical origins. Expected outcomes of this research include novel analysis methods and software tools, which should broadly and significantly benefit gene discovery in other species, including those of agricultural relevance.Read moreRead less
Elucidating the genetics of attention deficit hyperactivity disorder by integrating pathway and prediction analyses. Attention deficit hyperactivity disorder (ADHD) is the most common psychiatric disorder in children; while treatments are available they are ineffective for many patients. This project will develop methods for predicting genetic effects at the level of the biological mechanism to assist in identifying new drug targets and behavioural interventions.
New-generation flexible thermoelectrics for wearable electronics. This project aims to develop lightweight, flexible, and durable thermoelectric thin films for wearable electronics using a computation-guided approach, coupled with novel device design and materials nanoengineering strategies. The key breakthrough will overcome the stereotype of fragile thermoelectric materials and their low thermoelectric efficiency for achieving localised, instant, and controllable power generation and/or coolin ....New-generation flexible thermoelectrics for wearable electronics. This project aims to develop lightweight, flexible, and durable thermoelectric thin films for wearable electronics using a computation-guided approach, coupled with novel device design and materials nanoengineering strategies. The key breakthrough will overcome the stereotype of fragile thermoelectric materials and their low thermoelectric efficiency for achieving localised, instant, and controllable power generation and/or cooling with record-high performance in carefully designed wearable thermoelectric devices. Expected outcomes include new understanding of thermoelectrics and innovative technologies for achieving electronics/energy applications, which will provide significant economic and educational benefits for Australia.Read moreRead less
Broadband quantum networking with trapped ions. Banks and governments are now using short-range quantum communication to transmit data with secrecy guaranteed by the laws of physics. This project aims to develop the key ingredient for future broadband quantum networks: high-speed transmitters delivering quantum light pulses over present-day fibre-optic telecom infrastructure.
The role of strong duality in computer vision. This project aims to undertake research in the fields of computer vision and optimization that will have a significant impact on the design of numerical algorithms for solving a wide range of problems in Computer Vision, Virtual Reality and Robotic Navigation. This project will advance understanding of a broad class of problems related to how computers interpret images. An expected outcome is the generation of novel mathematical theory and numerical ....The role of strong duality in computer vision. This project aims to undertake research in the fields of computer vision and optimization that will have a significant impact on the design of numerical algorithms for solving a wide range of problems in Computer Vision, Virtual Reality and Robotic Navigation. This project will advance understanding of a broad class of problems related to how computers interpret images. An expected outcome is the generation of novel mathematical theory and numerical algorithms capable of fundamentally changing the way problems relevant to a wide range of vision-related applications are solved. This should offer Australia a strong competitive advantage as a leader in scientific innovation in the areas of Computer Vision, Virtual Reality and Robotics and Autonomous Systems.Read moreRead less
A pictorial communication framework for inclusion. A picture can tell a thousand words; many people with an intellectual disability can only communicate with pictures and are otherwise isolated. This project will research how computers can understand and facilitate a rich pictorial communication between people and person to machine, thereby supporting inclusion. This will be achieved by inclusively co-designing with people with ID and members of the community: a) an audio-visual accessible searc ....A pictorial communication framework for inclusion. A picture can tell a thousand words; many people with an intellectual disability can only communicate with pictures and are otherwise isolated. This project will research how computers can understand and facilitate a rich pictorial communication between people and person to machine, thereby supporting inclusion. This will be achieved by inclusively co-designing with people with ID and members of the community: a) an audio-visual accessible search tool, b) a pictorial communication device, and c) a visual inclusive social network. These applications will inform future innovations for everyone, and allow citizens with ID to access online information, participate in community activities and be included in the workplace.Read moreRead less
Ultimately Trusted Security through Human-Powered Cryptography. Cryptography offers wonderful tools for unbreakable data security, but only between computer nodes, leaving their human owners helpless. Encrypted tunnels terminate not at humans but at mobile phones and personal computers, exposing users' secrets to spyware from search-engine keyloggers to full-bore malware planted by crooks, hackers, and foreign spy agencies. This project aims to create a simple and strong cryptography, so that hu ....Ultimately Trusted Security through Human-Powered Cryptography. Cryptography offers wonderful tools for unbreakable data security, but only between computer nodes, leaving their human owners helpless. Encrypted tunnels terminate not at humans but at mobile phones and personal computers, exposing users' secrets to spyware from search-engine keyloggers to full-bore malware planted by crooks, hackers, and foreign spy agencies. This project aims to create a simple and strong cryptography, so that humans can, for the first time, take front seat in real security protocols. The technical challenge is to build public-key ciphers, operable manually from a mental key in seconds, and from there remake human-powered versions of many useful information security protocols.Read moreRead less