Gain modulation and stability in biological neural systems. This project is relevant to the National Research Priority area of Frontier Technologies and addresses fundamental cross-disciplinary issues of control and information processing in large, distributed neural systems that are at the cutting edge of intelligent processing systems. Applications are in rapidly growing fields of robotics, machine learning, adaptive control and intelligent systems, all with applications in diverse areas of ec ....Gain modulation and stability in biological neural systems. This project is relevant to the National Research Priority area of Frontier Technologies and addresses fundamental cross-disciplinary issues of control and information processing in large, distributed neural systems that are at the cutting edge of intelligent processing systems. Applications are in rapidly growing fields of robotics, machine learning, adaptive control and intelligent systems, all with applications in diverse areas of economic importance. Applications to cochlear implant speech processing will provide benefit for the hearing impaired. The project will provide students with training at an international level within Australia, thus helping ensure Australia maintains and extends its science and technology base into the futureRead moreRead less
Functionally characterizing mammalian microRNAs and mRNA interactions controlling cell division. This project addresses some of the most burning issues in molecular biology and genetic research, and the results will be widely applicable to a broad range of fields, including biotechnology, animal breeding, agricultural production, genetic engineering, medical science, and computational biology. By understanding the regulatory potential of microRNA molecules, we will understand more about species ....Functionally characterizing mammalian microRNAs and mRNA interactions controlling cell division. This project addresses some of the most burning issues in molecular biology and genetic research, and the results will be widely applicable to a broad range of fields, including biotechnology, animal breeding, agricultural production, genetic engineering, medical science, and computational biology. By understanding the regulatory potential of microRNA molecules, we will understand more about species diversity, regulatory networks, and plant and animal development. The early adoption of multi-gigabase next-generation sequencing technology in Australia provides rare and exciting opportunity to lead the world in genome-scale research, and to ensure that Australia has the necessary skill base to remain internationally competitive in this field.Read moreRead less
Understanding cortical processing: Neuronal activity and learning in recurrently connected networks. This project addresses fundamental cross-disciplinary issues of information processing and control in large-scale biological neural systems. This is an area of research that is at the cutting edge of intelligent processing systems. An understanding of these mechanisms would have considerable implications in areas that span a range of complex biological and artificial neural systems, including the ....Understanding cortical processing: Neuronal activity and learning in recurrently connected networks. This project addresses fundamental cross-disciplinary issues of information processing and control in large-scale biological neural systems. This is an area of research that is at the cutting edge of intelligent processing systems. An understanding of these mechanisms would have considerable implications in areas that span a range of complex biological and artificial neural systems, including the rapidly growing fields of robotics, machine learning, and adaptive control, all with applications in diverse areas of economic importance. The project will provide students with training at an international level within Australia, thus helping ensure Australia maintains and extends its science and technology base.Read moreRead less
Statistical and Mathematical Analyses of Sequence and Array Data. Development of mathematical and statistical methods and tools in bioinformation science will ensure that Australia is at the cutting-edge of modern biology. This will enhance Australia's reputation for dealing with the exponentially growing body of genomic data emerging from life sciences laboratories throughout the world. The proposed project has a broad range of potential applications in biotechnology, particularly in the medic ....Statistical and Mathematical Analyses of Sequence and Array Data. Development of mathematical and statistical methods and tools in bioinformation science will ensure that Australia is at the cutting-edge of modern biology. This will enhance Australia's reputation for dealing with the exponentially growing body of genomic data emerging from life sciences laboratories throughout the world. The proposed project has a broad range of potential applications in biotechnology, particularly in the medical and agricultural industries. Examples include improvements to livestock, in plant breeding such as drought resistance, and better genetic disease diagnosis, including earlier cancer diagnosis, and personalised treatment.Read moreRead less
Genetic variation of transcriptional control. Genetic variation is a key cause phenotype differences in humans, animals, and plants and so of great economic importance. Despite its proven importance to human diseases, ?quantitative? variation in the amount of gene expression rather than ?qualitative? protein sequence changes, has not been systematically studied. We have developed a powerful method to identify genetic causes of quantitative variation using crosses of inbred mice in conjunction wi ....Genetic variation of transcriptional control. Genetic variation is a key cause phenotype differences in humans, animals, and plants and so of great economic importance. Despite its proven importance to human diseases, ?quantitative? variation in the amount of gene expression rather than ?qualitative? protein sequence changes, has not been systematically studied. We have developed a powerful method to identify genetic causes of quantitative variation using crosses of inbred mice in conjunction with microarray techniques to analyse expression of thousands of genes simultaneously. These studies will be extended to humans and be significant to wide areas of biological and commercial activity.Read moreRead less
Topological Approaches for Three Dimensional Graph Drawing. Human analysis of huge quantities of relational data in biotechnology, web engineering, social networks, and computer networks requires visualization. In recent years, three-dimensional visualisation has promised to give new insights into such abstract data. However the past ten years of visualization research has had very little impact on the industry; visualization software providers have not adopted visualization methods developed b ....Topological Approaches for Three Dimensional Graph Drawing. Human analysis of huge quantities of relational data in biotechnology, web engineering, social networks, and computer networks requires visualization. In recent years, three-dimensional visualisation has promised to give new insights into such abstract data. However the past ten years of visualization research has had very little impact on the industry; visualization software providers have not adopted visualization methods developed by academics. We hypothesise that current 3D relational visualization methods fail because they do not pay attention to the human perception of topology. In this project we will leverage mathematical topology to construct new methods for the 3D visualization of relational data.
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New Methods for Interactive Visualization of Large Microarray Data Sets. This project will investigate methods for visualising graphs produced by AI-based analysis of real-world biological data. These new visualisation methods will assist biologists to develop new DNA Microarray experiments, the source of raw data for visualisation. Data from new enhanced experiments, plus background knowledge from integrated public databases will produce richer data for visualisation, thus creating a positive f ....New Methods for Interactive Visualization of Large Microarray Data Sets. This project will investigate methods for visualising graphs produced by AI-based analysis of real-world biological data. These new visualisation methods will assist biologists to develop new DNA Microarray experiments, the source of raw data for visualisation. Data from new enhanced experiments, plus background knowledge from integrated public databases will produce richer data for visualisation, thus creating a positive feedback loop in the course of research into both topics.Read moreRead less
Traversing a treacherous landscape: Modelling caterpillar movement and behaviour on whole plants at multiple scales. How caterpillars move on plants and where they feed is central to developing plants resistant to these insect pests. Our research program will generate computer models of caterpillar behaviour on virtual plants that interact in realistic ways with the changing structure of the plant as it grows, its micro-architecture and environment. We provide a set of tools that will form the ....Traversing a treacherous landscape: Modelling caterpillar movement and behaviour on whole plants at multiple scales. How caterpillars move on plants and where they feed is central to developing plants resistant to these insect pests. Our research program will generate computer models of caterpillar behaviour on virtual plants that interact in realistic ways with the changing structure of the plant as it grows, its micro-architecture and environment. We provide a set of tools that will form the cornerstone of important future research agendas in the ecology of foraging caterpillars, optimisation of insecticide spray application, and the development of novel genetically transformed plants for insect control central to the future of Australian agriculture.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882979
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Australian High Performance Computational Structural Biology Facility. This work will have major outcomes for structural biology research at a national and international level. For structure determination, the ability to perform massively parallel calculations will afford a timesaving of weeks to months. Further, significant insights will be gained into the use of high-performance grid computing in protein structure determination by X-ray crystallography. This knowledge has considerable impact ....Australian High Performance Computational Structural Biology Facility. This work will have major outcomes for structural biology research at a national and international level. For structure determination, the ability to perform massively parallel calculations will afford a timesaving of weeks to months. Further, significant insights will be gained into the use of high-performance grid computing in protein structure determination by X-ray crystallography. This knowledge has considerable impact on our ability to undertake high quality structural biology research - a key area in the majority of biological research programs. Software developed will be made available to academic researchers free of charge.Read moreRead less
Emergence of robust, stable structures via computation within natural networks. An ever-increasing challenge for modern society is the sheer complexity of vast infrastructures. Unexpected, and sometimes catastrophic, behaviour often emerges from interactions between elements of large systems. As a result, highly complex systems such as the Internet, international finance markets, and power grids are highly susceptible to costly problems such as cascading failures, inefficiency, and critical sens ....Emergence of robust, stable structures via computation within natural networks. An ever-increasing challenge for modern society is the sheer complexity of vast infrastructures. Unexpected, and sometimes catastrophic, behaviour often emerges from interactions between elements of large systems. As a result, highly complex systems such as the Internet, international finance markets, and power grids are highly susceptible to costly problems such as cascading failures, inefficiency, and critical sensitivity. High-tech industries, such as biotechnology and information networking, also face problems in coordinating swarms of interacting agents. This project will contribute to solving such problems by identifying and adapting solutions from nature.Read moreRead less