Using genetics to reconstruct the peopling and diversification of Sahul. A recent landmark study has revealed that people who first arrived on Sahul (the landmass connecting Australia with New Guinea) remained largely genetically isolated from subsequent migrations. However, there is still little known about the route(s) taken into Sahul, or how adaptation has shaped the enormous diversity now observed across Indigenous Australians and Papuans. This project aims to look at these issues by applyi ....Using genetics to reconstruct the peopling and diversification of Sahul. A recent landmark study has revealed that people who first arrived on Sahul (the landmass connecting Australia with New Guinea) remained largely genetically isolated from subsequent migrations. However, there is still little known about the route(s) taken into Sahul, or how adaptation has shaped the enormous diversity now observed across Indigenous Australians and Papuans. This project aims to look at these issues by applying phylogenetic and population genetic tools to the largest genetic dataset yet analysed from populations across Australia, New Guinea, and Island South East Asia. The outcomes of the project should reveal both the route(s) taken into Sahul and how adaptation has shaped the diversity now observed in descendants of the colonisation.Read moreRead less
The basis of oyster resilience to global environmental change. This project aims to investigate the impact of global environmental change on the survival of Australia’s oyster industry, by combining the science of genetics, physiology and ecology to identify already resilient oysters. Through the first complete understanding of resilience in oysters, including the trade-offs they have made in other fitness traits, the project develops new capacities to 'climate and future-proof' our natural oyst ....The basis of oyster resilience to global environmental change. This project aims to investigate the impact of global environmental change on the survival of Australia’s oyster industry, by combining the science of genetics, physiology and ecology to identify already resilient oysters. Through the first complete understanding of resilience in oysters, including the trade-offs they have made in other fitness traits, the project develops new capacities to 'climate and future-proof' our natural oyster populations and the Australian oyster industry, to enable the restoration of degraded oyster habitats. This project will ensure the future of an iconic and economically important national industry and food source and contribute to preserving the critical cultural links of Indigenous Australians with their lands.Read moreRead less
The importance of DNA methylation in response to environmental changes. This project aims to investigate the importance of DNA methylation, a process whereby gene expression can be altered without changes in the DNA code, in regulating our responses to environmental challenges. It plans to do so using well-validated models of adult exposure to high fat diet or psychological stress in mice and tissue-specific (liver and brain) deletion of the major methylation enzymes. It aims to compare function ....The importance of DNA methylation in response to environmental changes. This project aims to investigate the importance of DNA methylation, a process whereby gene expression can be altered without changes in the DNA code, in regulating our responses to environmental challenges. It plans to do so using well-validated models of adult exposure to high fat diet or psychological stress in mice and tissue-specific (liver and brain) deletion of the major methylation enzymes. It aims to compare functional, gene expression and methylation status after such challenges in intact and methylase deleted animals to determine how vital this process really is. This work has major implications for our understanding of epigenetics, and the ways in which genes interact with the environment especially in times of change.Read moreRead less
The evolution of cooperative communication. This interdisciplinary project will provide a broad understanding of communication in a model ecological system involving ants, lycaenid butterflies, and host-plants. The project will reveal the nature of the chemical signals used to communicate, and their role in the origin, maintenance, and loss of mutualistic and parasitic associations.
Characterisation of tumour variants of Devil Facial Tumour Disease. This project will take a new approach to cancer research by studying the evolution of Devil Facial Tumour Disease. The results will directly contribute to the conservation management of the Tasmanian devil, as well as generating new information on tumour growth, metastasis and emergence of resistance.
Evolution of defensive and predatory venom in cone snails. This project aims to determine the molecular and cellular origins and mechanisms regulating venom production and release to establish how defensive venoms evolved in cone snails. Cone snails possess a remarkable ability to rapidly and reversibly switch between separate venoms in response to predatory or defensive stimuli, implying that these are separately evolved and regulated mechanisms. The investigators hypothesise that defensive ven ....Evolution of defensive and predatory venom in cone snails. This project aims to determine the molecular and cellular origins and mechanisms regulating venom production and release to establish how defensive venoms evolved in cone snails. Cone snails possess a remarkable ability to rapidly and reversibly switch between separate venoms in response to predatory or defensive stimuli, implying that these are separately evolved and regulated mechanisms. The investigators hypothesise that defensive venoms, originally evolved in the proximal venom duct to protect against threats such as cephalopod and fish predation, have been repurposed in the proximal duct to allow predators to become prey, facilitating the switch from worm to mollusc and fish hunting. The project aims to show the broad implications for the evolution of venoms in animals and discover the regulatory mechanisms driving venom peptide expression.Read moreRead less
Increased phenotypic variation via evolutionarily novel stressors. This project aims to understand how evolutionarily novel stressors such as obesogenic diets induce phenotypic variation in organismal traits. Such increased phenotypic variation is traditionally thought to be genetic. However, growing evidence points to non-genetic mechanisms that are capable of transgenerational inheritance. The project will use complementary approaches to study how novel stressors generate phenotypic variation ....Increased phenotypic variation via evolutionarily novel stressors. This project aims to understand how evolutionarily novel stressors such as obesogenic diets induce phenotypic variation in organismal traits. Such increased phenotypic variation is traditionally thought to be genetic. However, growing evidence points to non-genetic mechanisms that are capable of transgenerational inheritance. The project will use complementary approaches to study how novel stressors generate phenotypic variation. The project aims to deliver a more integrated evolutionary perspective not only on phenotypic evolution and the maintenance of variation, but also on the transgenerational cost of obesity.Read moreRead less
Building giants: the origins of extreme biology in baleen whales. Baleen whales are unlike any other animal. They have evolved unparalleled specialisations for feeding, hearing, smell, cognition and – above all – the largest ever body size. These extreme features underlie the unmatched dominance of baleen whales in today's oceans. The origins of these key adaptations required major changes in the anatomy and function of the skull and teeth. However, exactly how and when the extreme innovations o ....Building giants: the origins of extreme biology in baleen whales. Baleen whales are unlike any other animal. They have evolved unparalleled specialisations for feeding, hearing, smell, cognition and – above all – the largest ever body size. These extreme features underlie the unmatched dominance of baleen whales in today's oceans. The origins of these key adaptations required major changes in the anatomy and function of the skull and teeth. However, exactly how and when the extreme innovations of baleen whales began remains an outstanding question in animal biology. This proposal aims to combine exceptional Australian fossils with recent advances in 3D imaging, biomechanics, and evolutionary analysis to discover how the secrets to the success of baleen whales first evolved.Read moreRead less
The functions of reef fish colour patterns: how did the coral trout get its spots? How did the coral trout get its spots? Why are some reef fish striped yellow and blue while others dress in pink and orange blotches? This project goes beyond just interpreting animal colours and uses a new approach to reveal the meanings of whole body patterns. Uniquely, it does so through the eyes of the fish themselves.
Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement. This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, ....Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement. This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, as well as the nabarlek itself, the developmental processes and genes involved in molar generation and movement will be revealed. This project will integrate findings in regenerative medicine, evolutionary biology, materials engineering and palaeontology to reveal the mechanisms and origins of this astounding capability.Read moreRead less