Simultaneous Targeting Of Contraception And Sexually Transmitted Disease
Funder
National Health and Medical Research Council
Funding Amount
$681,380.00
Summary
This research will generate a completely novel topical contraceptive agent that becomes activated on contact with semen and will simultaneously protect the user against both unwanted fertility and sexually transmitted disease. A prototype compound has already been developed and patented. This research is aimed at the chemical optimization of this reagent, analysis of its mechanism-of-action and characterization of its anti-microbial activity against chlamydia, gonorrhoea, herpes simplex and HIV
Characterization Of The Molecular Basis Of Human Sperm-oocyte Interaction
Funder
National Health and Medical Research Council
Funding Amount
$492,956.00
Summary
In this proposal, we shall exploit our expertise in gamete biology and innovative proteomic technologies to elucidate the molecular mechanisms that underpin human sperm-oocyte interaction. This exquisitely cell- and species-specific event constitutes one of the most strategically important cellular interactions. Our research will provide the foundation for diagnosis and treatment of male infertility and identify a range of targets for the development of novel contraceptive technology.
I am a clinician-scientist with a focus on basic and translational research in male reproductive physiology and health disorders, notably infertility, contraception and androgen action.
Novel Function Of Heat Shock Protein 2A In The Regulation Of Human Sperm-egg Interactions
Funder
National Health and Medical Research Council
Funding Amount
$302,627.00
Summary
Male infertility is an extremely common condition affecting around 1 in 20 Australian men. One of the major reasons for this pathology is that the spermatozoa have lost their ability to recognize the egg. In this project we shall investigate whether this defect is due to a deficiency in a specific protein (HSPA2). This project will provide new and powerful insights into the causes of male infertility, with practical implications for prevention, diagnosis and treatment of this condition.
I am a reproductive biologist focused on women’s reproductive health. I am studying the reasons why some women are infertile have spontaneous abortions and pregnancy complications such as pre-eclampsia. My research will define the roles of molecules that are critical in the establishment of pregnancy and the formation of a health placenta and therefore a healthy baby.