Role For Zinc And ZIP2 In The Action Of Nitric Oxide And In Vascular Protection Against Cigarette Smoke And Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$685,941.00
Summary
The NO/cGMP signalling pathway, which is central to cardiovascular physiology and protection against disease, is only fully effective when there are adequate levels of zinc in the vascular endothelium. This is especially important where zinc stores are depleted (elderly, smokers, diabetics and kidney disease). There is an urgent clinical need to implement strategies to monitor vascular Zn status. This application will explore the underlying science and translate these to the clinic.
Alveolar Macrophage Zinc And Zinc Transporters And Their Role In Phagocytosis
Funder
National Health and Medical Research Council
Funding Amount
$288,975.00
Summary
Zinc is an essential dietary component that serves a number of functions in the lungs. It is both an anti-oxidant and anti-inflammatory agent. Some airway inflammatory diseases such as emphysema may involve a critical loss of lung zinc. We believe that cigarette smoke causes the loss of zinc and this prevents the lung macrophages from working properly to clear bacteria and dead cells. This will provide a foundation for our long term goals of better clinical management of emphysema.
Airway Epithelial IAPs And Their Interaction With Zn Ions
Funder
National Health and Medical Research Council
Funding Amount
$260,779.00
Summary
The air we breathe contains a variety of harmful substances. Damage to the lining involves death of the ciliated cells that line the airways. We have shown that zinc protects these cells from premature death. This application focuses on a family of proteins called IAPs which bind zinc and regulate cell death in other tissues. This project focusses on how the IAPs and Zn may act together to mainitain healthy airways and how abnormalities of these may occur in people with asthma.
Role Of Zinc In The Respiratory Epithelium And Asthma
Funder
National Health and Medical Research Council
Funding Amount
$224,250.00
Summary
This project will use a panel of Zinquin-derived Zn fluorophores developed in our laboratory, as well as probes for the mammalian family of vesicular ZnT transporters, to carry out a study of the normal physiology of Zn in the respiratory system and potential abnormalities of this in patients with chronic inflammatory respiratory disease (asthma, COPD, chronic smoking). Chronic inflammatory diseases of the respiratory tract affect a significant proportion of the Australian community. For example ....This project will use a panel of Zinquin-derived Zn fluorophores developed in our laboratory, as well as probes for the mammalian family of vesicular ZnT transporters, to carry out a study of the normal physiology of Zn in the respiratory system and potential abnormalities of this in patients with chronic inflammatory respiratory disease (asthma, COPD, chronic smoking). Chronic inflammatory diseases of the respiratory tract affect a significant proportion of the Australian community. For example, asthma affects 12% of adults and amongst these, 15% waken weekly or more often with their asthma while 6% are hospitalized annually. There is a need to understand the basic mechanisms underlying these diseases so that new strategies can be developed to modify bronchocondtriction and inflammation. The project will provide new knowledge concerning the physiology of Zn in the respiratory epithelium and interactions between Zn deficiency and oxidants on injury in the respiratory tract. The usefulness of easily accessible nasal epithelial cells as a measure of Zn and Zn transporter levels deeper in the respiratory tract will be assessed. The project encompasses a number of fields and utilizes in vitro cellular and animal models, as well as tissues from human subjects.Read moreRead less
Reverse engineering nature: metal extraction through mineral replacement. This project aims to find new methods of copper recovery from low grade copper ores, which are currently uneconomic to mine. In nature, at the top of ore deposits and just below the water-table, is a region known as the supergene zone. Here mild oxidizing reactions take place causing primary ore minerals such as chalcopyrite to be replaced by more copper-rich, less refractory minerals. These processes are driven by disso ....Reverse engineering nature: metal extraction through mineral replacement. This project aims to find new methods of copper recovery from low grade copper ores, which are currently uneconomic to mine. In nature, at the top of ore deposits and just below the water-table, is a region known as the supergene zone. Here mild oxidizing reactions take place causing primary ore minerals such as chalcopyrite to be replaced by more copper-rich, less refractory minerals. These processes are driven by dissolution re-precipitation reactions (CDR reactions) and in many CDR reactions, the reaction mechanism, rather than intensive properties such as pressure and temperature, control the nature of the products and the overall reaction process. This project will explore the mechanism and controls on these reactions to see if they can be utilized in the mining industry to economically extract copper from low grade ores.
Read moreRead less
Three-dimensional magnetotelluric imaging of lithospheric-scale mineral systems from source to deposit. Geochemical studies indicate that world-class mineral deposits are partly sourced from fluids emerging from Earth's mantle and lower crust. Finding major mineral deposits in the future will therefore require knowledge of which parts of the crust and mantle yield the most prospective locations. However, there are few methods that can image deep Earth resources, and these can be very expensive ....Three-dimensional magnetotelluric imaging of lithospheric-scale mineral systems from source to deposit. Geochemical studies indicate that world-class mineral deposits are partly sourced from fluids emerging from Earth's mantle and lower crust. Finding major mineral deposits in the future will therefore require knowledge of which parts of the crust and mantle yield the most prospective locations. However, there are few methods that can image deep Earth resources, and these can be very expensive. We propose to develop the magnetotelluric method as a low-cost and rapid approach for delineating 3D information on deep mineral systems beneath existing major deposits, and adapting this to explore in greenfield locations.Read moreRead less
Physical and Chemical Constraints of Fluid Activated Processes During the Polyphase Tectonic Evolution of the Olary Domain, S.A. The Olary Domain, eastern South Australia, underwent several phases of deformation and metamorphism. These events mobilised fluids leading, amongst other features, to the formation of breccia bodies and mineral deposits. The complex nature of the geological evolution of the region obscures relationships of fluid migration to the structural history. Fluid inclusion stud ....Physical and Chemical Constraints of Fluid Activated Processes During the Polyphase Tectonic Evolution of the Olary Domain, S.A. The Olary Domain, eastern South Australia, underwent several phases of deformation and metamorphism. These events mobilised fluids leading, amongst other features, to the formation of breccia bodies and mineral deposits. The complex nature of the geological evolution of the region obscures relationships of fluid migration to the structural history. Fluid inclusion studies and stable isotope analyses combined with structural analyses on micro to macro scales shall establish links between the thermal and structural evolution of the area. This will provide insigth into the scale and physico-chemical characteristics of fluids and mineralising processes an relate these to the tectono-thermal history.Read moreRead less
The Genesis and Tectonic Setting of Iron Oxide Associated Mineralisation in Germany and South Australia. FeOx associated mineralisations are not restricted to Olympic Dam and Ernest Henry types but occur in various geological settings, e.g. the Mt Painter and Olary region, S A. Ocurrences in Central Europe (Erzgebirge, Harz/Calvörde) contain U and other metals, their structural setting is well recorded. Together with the Bergakademie Freiberg, Germany, and the University of Nancy, France, these ....The Genesis and Tectonic Setting of Iron Oxide Associated Mineralisation in Germany and South Australia. FeOx associated mineralisations are not restricted to Olympic Dam and Ernest Henry types but occur in various geological settings, e.g. the Mt Painter and Olary region, S A. Ocurrences in Central Europe (Erzgebirge, Harz/Calvörde) contain U and other metals, their structural setting is well recorded. Together with the Bergakademie Freiberg, Germany, and the University of Nancy, France, these mineralisations shall be investigated with modern geological and geochemical methods to develop a unifying model for the genesis of iron oxide associated U-metal-REE deposits. This will help identifying exploration targets and distinguish different types of mineralisation upon their genetic setting.Read moreRead less
Deep and smelly: exploring the roles of pressure and sulphur in hydrothermal metal transport. Hot, salty fluids carry metals in the Earth's crust and are responsible for the formation of Australia's mineral wealth. This project combines exciting new experiments with molecular-level simulations to predict metal transport, providing a sound basis for improving mineral exploration models and sustaining discovery of new deposits.
Mobility of metals in hydrothermal solutions: critical experiments and numerical modelling tools to improve exploration success and ore processing. After more than 100 years of intense prospecting, ore deposits with a surface expression or a characteristic geophysical signature have been discovered. As a result, the industry needs innovative and quantitative exploration techniques. Geochemical exploration suffers from a growing gap between ever more powerful geochemical analytical capabilities a ....Mobility of metals in hydrothermal solutions: critical experiments and numerical modelling tools to improve exploration success and ore processing. After more than 100 years of intense prospecting, ore deposits with a surface expression or a characteristic geophysical signature have been discovered. As a result, the industry needs innovative and quantitative exploration techniques. Geochemical exploration suffers from a growing gap between ever more powerful geochemical analytical capabilities and the poor understanding of fundamental processes in hydrothermal systems. By combining new experiments on important geochemical systems (association between the trace elements Te and As with Au) with advances in numerical modelling of H2O-CO2-NaCl fluids, the project aims to bring geochemical exploration in line with geophysical exploration.Read moreRead less