Promoting active travel and public transport for a post-pandemic world. In many major cities, COVID-19 stimulated the provision of open streets, pop up bike lanes and widened pedestrian access, prompting unprecedented increases cycling and walking. While this type of infrastructure has always been supported by urban planners and designers, the pandemic has served as a vital inflection point, enabling cities to pursue long-term sustainable transport initiatives, including investment in Active Tra ....Promoting active travel and public transport for a post-pandemic world. In many major cities, COVID-19 stimulated the provision of open streets, pop up bike lanes and widened pedestrian access, prompting unprecedented increases cycling and walking. While this type of infrastructure has always been supported by urban planners and designers, the pandemic has served as a vital inflection point, enabling cities to pursue long-term sustainable transport initiatives, including investment in Active Travel (AT). There is an opportunity to promote AT as part of an integrated transport strategy, and to develop tools for the robust evaluation of AT impacts to inform future investment strategies. This proposal will provide our partner organisation Transport for New South Wales (with the knowledge required to achieve this.
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Assessing the determinants and consequences of safety climate in the maritime industry. This project will examine the predictors and outcomes of safety climate in the Australian maritime industry. Findings from this project will be used to improve safety policies, regulations and practices that aim to minimise the number of accidents and incidents in Australian waters.
A systemic model to underpin enhanced management of powered-two-wheelers as part of a safe, sustainable transport system. Better management of motor scooters and motorbikes (Powered-2-wheelers or P2W) will deliver economic, environmental and social benefits. Road crashes involving P2Ws cost the Australian community in excess of $2 billion per annum. There are also the broader social impacts for crash victims, their families and communities from the potentially long-term pain, grief and debilitat ....A systemic model to underpin enhanced management of powered-two-wheelers as part of a safe, sustainable transport system. Better management of motor scooters and motorbikes (Powered-2-wheelers or P2W) will deliver economic, environmental and social benefits. Road crashes involving P2Ws cost the Australian community in excess of $2 billion per annum. There are also the broader social impacts for crash victims, their families and communities from the potentially long-term pain, grief and debilitating injuries. This project will provide insight into how the incidence and costs associated with P2W crashes can be reduced. In addition, congestion costs in each of Australia's capital cities are on the order of $3 billion per annum and there is potential for P2W research to reduce not only that cost but also the broader environmental impacts of travel by providing an alternative to cars.Read moreRead less
The global consequences of subduction zone congestion. This project will use a combination of 3D geodynamic modelling, plate kinematic reconstruction and geological and geophysical synthesis to determine how congested subduction zones influence plate kinematics, subduction dynamics and tectonic evolution at orogen and global scales. The project aims to deliver a transformation change in understanding the links between congested subduction, mantle flow, trench migration, crustal growth, transitio ....The global consequences of subduction zone congestion. This project will use a combination of 3D geodynamic modelling, plate kinematic reconstruction and geological and geophysical synthesis to determine how congested subduction zones influence plate kinematics, subduction dynamics and tectonic evolution at orogen and global scales. The project aims to deliver a transformation change in understanding the links between congested subduction, mantle flow, trench migration, crustal growth, transitions between stable convergent margin configurations and deformation in the overriding plates of subduction zones. Determining these relationships is significant because it will provide dynamic context to interpret the geological record of ancient convergent margins, which host a large percentage of Earth's metal resources.Read moreRead less
Fluid-thermal-structural interactions on high-speed aerospace vehicles. Sixteen years after the retirement of Concorde, high-speed commercial flight is once again on the rise with the development of new supersonic business jets and small airliners as well as hypersonic transport and reusable space launch systems. Robust and efficient designs for these light-weight vehicles must address the problem of aerodynamic heating and its effect on structural performance and lifing. This project will desig ....Fluid-thermal-structural interactions on high-speed aerospace vehicles. Sixteen years after the retirement of Concorde, high-speed commercial flight is once again on the rise with the development of new supersonic business jets and small airliners as well as hypersonic transport and reusable space launch systems. Robust and efficient designs for these light-weight vehicles must address the problem of aerodynamic heating and its effect on structural performance and lifing. This project will design and perform first-of-kind experiments that reproduce the complex fluid-thermal-structural interactions representative of those experienced by these aircraft and rockets. We will then use these measurements to assess, validate and improve the current state-of-the-art of simulation and modelling approaches for design.Read moreRead less
Where to find giant porphyry and epithermal gold and copper deposits. This project will determine when and where giant gold or copper deposits should form, consolidating links with Indonesia, and using South East Asia as a vast natural laboratory in which to examine the effect of large-scale tectonic processes. The project will produce a four-dimensional virtual exploration toolkit to show how to apply the methods.
Fluid-structural interactions in high-speed flows. This project aims to perform experiments to measure fluid-structure interaction in hypersonic flows. The work will improve the accuracy of simulation tools that are urgently required to aid industry in the design of more structurally efficient and robust high-speed vehicles. These tools will in turn be used to reveal the underlying physics of the fluid-structure interactions and establish the relative significance of the driving parameters. Accu ....Fluid-structural interactions in high-speed flows. This project aims to perform experiments to measure fluid-structure interaction in hypersonic flows. The work will improve the accuracy of simulation tools that are urgently required to aid industry in the design of more structurally efficient and robust high-speed vehicles. These tools will in turn be used to reveal the underlying physics of the fluid-structure interactions and establish the relative significance of the driving parameters. Accurate prediction of the behaviour and lifetime of structural components subject to these fluid-structural interactions, in which the deformation of the structure induced by the local flow field, can in turn influence this flow field. This coupling can result in damage or even catastrophic structural failure and thus robust design tools must be developed to avoid this.Read moreRead less
Improving external validity of stated choice experiments. This project aims to deliver more accurate estimates of choice behaviour by reducing biases due to choice task complexity in surveys as well as design artefacts. Extracting 'true' preferences is challenging, not only due to possible hypothetical bias, but also due to increasingly complex choice tasks and the existence of design artefacts. This project will investigate the latter two in the context of marketing, transport, health, and envi ....Improving external validity of stated choice experiments. This project aims to deliver more accurate estimates of choice behaviour by reducing biases due to choice task complexity in surveys as well as design artefacts. Extracting 'true' preferences is challenging, not only due to possible hypothetical bias, but also due to increasingly complex choice tasks and the existence of design artefacts. This project will investigate the latter two in the context of marketing, transport, health, and environmental economics, and proposes new methodologies to extract preferences that more closely reflect true behaviour in real markets.Read moreRead less
Experimental constraints on the genesis of gold-rich ore deposits. The project will provide a new set of tools to explore for gold-rich ore deposits in Australia and globally. By integrating geochemical studies with cutting-edge experiments carried out at three Australian universities in strategic partnership with industry, the outcomes of this project will provide much needed knowledge to predict the locations of large gold-rich deposits that are concealed beneath vast expanses of the Australia ....Experimental constraints on the genesis of gold-rich ore deposits. The project will provide a new set of tools to explore for gold-rich ore deposits in Australia and globally. By integrating geochemical studies with cutting-edge experiments carried out at three Australian universities in strategic partnership with industry, the outcomes of this project will provide much needed knowledge to predict the locations of large gold-rich deposits that are concealed beneath vast expanses of the Australian continent. The new results will translate into smarter exploration practice, significantly enhancing success in targeting ore deposits that are rich in high-value metal and display the smallest have a small environmental footprint, to underpin the sustainability of our nation into the future.
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Role Of Transition Metal Ions And Redox Activity In The Development Of Atherosclerotic Plaques
Funder
National Health and Medical Research Council
Funding Amount
$196,018.00
Summary
Metal ions such as iron and copper have been reproted to be present in the lesions present in diseased human arteries and it has been suggested that these metal ions contribute to the development of atherosclerosis (hardening of the arteries) via their ability to catalyse the formation of highly reactive molecualr fragments called free radicals. Though metal ions are known to catalyse such reactions in test-tube experiments, both the presence of metal ions in diseased arteries and their ability ....Metal ions such as iron and copper have been reproted to be present in the lesions present in diseased human arteries and it has been suggested that these metal ions contribute to the development of atherosclerosis (hardening of the arteries) via their ability to catalyse the formation of highly reactive molecualr fragments called free radicals. Though metal ions are known to catalyse such reactions in test-tube experiments, both the presence of metal ions in diseased arteries and their ability to generate free radicals is controversial. This study will employ a novel, minimally-invasive, technique to assess the nature and quantity of metal ions present in well-defined human and animal lesions at different stages of lesion development. The ability of these metal ions to catalyse free radical formation from components present in the artery wall will also be assessed. The release of these metal ions from the artery wall to added organic molecules will be assessed as this might minimise their potential to cause damage, and provide a possible therapeutic strategy. These studies will therefore provide valuable information as to the significance and role of reactive metal ions in the development of human artery disease and the possible prevention, or minimisation, of such processes.Read moreRead less