Radiotherapy Treatment For Prostate Cancer - A Change In Practice Based On Direct Evidence For Targeting And Toxicity Effects Using Real Outcomes Data
Funder
National Health and Medical Research Council
Funding Amount
$555,129.00
Summary
Radiotherapy for prostate cancer treatment will be more effective when we have better knowledge of what patient anatomy needs to be targeted, and what needs to be avoided. This project will combine data collected during a large Australasian prostate cancer radiotherapy trial, ‘RADAR’, with data collected using new patient imaging methods to determine how patient anatomy impacts on the effectiveness of their treatment and the side-effects they experience.
Heparin-induced Thrombocytopenia And Thrombosis: Better Understanding Of Pathogenesis And Improving Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$653,137.00
Summary
Heparin, a widely used drug, can cause an adverse effect which results in a fall of the platelet count and the development of serious thrombosis. This drug complication is mediated by an immune mechanism. This proposal aims to provide a better understanding of the disease mechanism. It also aims to develop a new test that will improve the diagnosis, and to produce a novel drug that will effectively suppress the immune reaction and improve the treatment.
Where to find giant porphyry and epithermal gold and copper deposits. This project will determine when and where giant gold or copper deposits should form, consolidating links with Indonesia, and using South East Asia as a vast natural laboratory in which to examine the effect of large-scale tectonic processes. The project will produce a four-dimensional virtual exploration toolkit to show how to apply the methods.
Role Of Transition Metal Ions And Redox Activity In The Development Of Atherosclerotic Plaques
Funder
National Health and Medical Research Council
Funding Amount
$196,018.00
Summary
Metal ions such as iron and copper have been reproted to be present in the lesions present in diseased human arteries and it has been suggested that these metal ions contribute to the development of atherosclerosis (hardening of the arteries) via their ability to catalyse the formation of highly reactive molecualr fragments called free radicals. Though metal ions are known to catalyse such reactions in test-tube experiments, both the presence of metal ions in diseased arteries and their ability ....Metal ions such as iron and copper have been reproted to be present in the lesions present in diseased human arteries and it has been suggested that these metal ions contribute to the development of atherosclerosis (hardening of the arteries) via their ability to catalyse the formation of highly reactive molecualr fragments called free radicals. Though metal ions are known to catalyse such reactions in test-tube experiments, both the presence of metal ions in diseased arteries and their ability to generate free radicals is controversial. This study will employ a novel, minimally-invasive, technique to assess the nature and quantity of metal ions present in well-defined human and animal lesions at different stages of lesion development. The ability of these metal ions to catalyse free radical formation from components present in the artery wall will also be assessed. The release of these metal ions from the artery wall to added organic molecules will be assessed as this might minimise their potential to cause damage, and provide a possible therapeutic strategy. These studies will therefore provide valuable information as to the significance and role of reactive metal ions in the development of human artery disease and the possible prevention, or minimisation, of such processes.Read moreRead less
Geochemistry of ore metals at very high temperatures. The world’s largest copper and gold mines occur in extinct volcanoes around the Pacific Rim. Understanding how these essential metals are mobilised from magmas in the roots of volcanoes to become ore deposits and how to recognize where this has occurred is crucial in exploration for new deposits.
New Lead-Free Brass Solutions for Drinking Water Applications. The aim of this Linkage Project is to provide viable material solutions to address the health problem of Lead-contamination in drinking water arising from Leaded-brass plumbing products and the impact Lead-removal from brass will have on the brass industry. In order to achieve this, this project engages leading multidisciplinary researchers along with Australian and international industry partners from across the brass industry suppl ....New Lead-Free Brass Solutions for Drinking Water Applications. The aim of this Linkage Project is to provide viable material solutions to address the health problem of Lead-contamination in drinking water arising from Leaded-brass plumbing products and the impact Lead-removal from brass will have on the brass industry. In order to achieve this, this project engages leading multidisciplinary researchers along with Australian and international industry partners from across the brass industry supply and sales network. This project seeks to identify and harness the key material-product attributes required to develop and implement new, lead-free alloy alternatives that meet health-compliance, production and commercial viability, that offer benefits across the industry network and health benefits to society.Read moreRead less
Ore deposits and tectonic evolution of the Lachlan Orogen, SE Australia. Ore deposits and tectonic evolution of the Lachlan Orogen, SE Australia. This project aims to develop and test models to evaluate past tectonic processes and configurations in South-east Australia, using both new and existing geological, geophysical and isotopic data. Over the past 550 million years, plate tectonic processes have formed metal-rich mineral deposits in South-east Australia. The project will identify areas of ....Ore deposits and tectonic evolution of the Lachlan Orogen, SE Australia. Ore deposits and tectonic evolution of the Lachlan Orogen, SE Australia. This project aims to develop and test models to evaluate past tectonic processes and configurations in South-east Australia, using both new and existing geological, geophysical and isotopic data. Over the past 550 million years, plate tectonic processes have formed metal-rich mineral deposits in South-east Australia. The project will identify areas of high potential for economically valuable ore deposits, enabling more efficient prioritisation of mineral exploration efforts. This is expected to increase the probability of significant ore deposit discoveries leading to national economic benefit.Read moreRead less
Evolution of Proterozoic multistage rift basins – key to mineral systems. This project will deliver a new quantitative and integrated exploratory framework for the mineral industry in Australia’s frontier sedimentary basins by integrating the latest advances in laboratory experimental tectonics with thermo-mechanical numerical, surface process and geophysical modelling. The project will use northern Australian basins as a natural laboratory to address the fundamental processes involved in the de ....Evolution of Proterozoic multistage rift basins – key to mineral systems. This project will deliver a new quantitative and integrated exploratory framework for the mineral industry in Australia’s frontier sedimentary basins by integrating the latest advances in laboratory experimental tectonics with thermo-mechanical numerical, surface process and geophysical modelling. The project will use northern Australian basins as a natural laboratory to address the fundamental processes involved in the development of sedimentary ore systems. The project will investigate how they can be detected by modern exploration techniques using a multidisciplinary approach with a team of experts with backgrounds in mineral and petroleum systems. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989123
Funder
Australian Research Council
Funding Amount
$575,000.00
Summary
Spark Plasma Sintering (SPS) Facility for Advanced Materials Processing. The establishment of the first Spark Plasma Sintering (SPS) facility would significantly enhance Australia's capacity in manufacturing of advanced materials, especially the more sophisticated and specialized materials, which is a National Research Priority. This facility will benefit a large number of researchers and projects in Australia's premier research organisations and will also meet the needs of organisations outside ....Spark Plasma Sintering (SPS) Facility for Advanced Materials Processing. The establishment of the first Spark Plasma Sintering (SPS) facility would significantly enhance Australia's capacity in manufacturing of advanced materials, especially the more sophisticated and specialized materials, which is a National Research Priority. This facility will benefit a large number of researchers and projects in Australia's premier research organisations and will also meet the needs of organisations outside the consortium. It will allow Australian researchers to remain at the leading edge of research and enhance collaborations in advanced materials nationwide. The successful outcomes of these activities will underpin the advancement in many areas of research and technology developments in the country.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560956
Funder
Australian Research Council
Funding Amount
$397,100.00
Summary
World-leading elemental and isotopic microanalysis and chemical speciation facilities for an environmentally sustainable Australia. We propose to establish a world-leading centre for the study of the elemental and isotopic composition of key environmental, archaeological and mineral samples. This will be based upon ultra-short wavelength laser ablation and speciation methods, combined with new advanced ICP-MS technologies developed in Australia. This will give the centre unrivalled capabilities ....World-leading elemental and isotopic microanalysis and chemical speciation facilities for an environmentally sustainable Australia. We propose to establish a world-leading centre for the study of the elemental and isotopic composition of key environmental, archaeological and mineral samples. This will be based upon ultra-short wavelength laser ablation and speciation methods, combined with new advanced ICP-MS technologies developed in Australia. This will give the centre unrivalled capabilities and allow new areas of research to be undertaken in global climate change, the impact of increased salinity and pollution on the sustainability of Australia's inland waterways and coastal environments, and the history of the first humans who inhabited Australia. This will provide a baseline and new quantitative measures to better plan for an environmentally sustainable Australia.Read moreRead less