Radiotherapy Treatment For Prostate Cancer - A Change In Practice Based On Direct Evidence For Targeting And Toxicity Effects Using Real Outcomes Data
Funder
National Health and Medical Research Council
Funding Amount
$555,129.00
Summary
Radiotherapy for prostate cancer treatment will be more effective when we have better knowledge of what patient anatomy needs to be targeted, and what needs to be avoided. This project will combine data collected during a large Australasian prostate cancer radiotherapy trial, ‘RADAR’, with data collected using new patient imaging methods to determine how patient anatomy impacts on the effectiveness of their treatment and the side-effects they experience.
Heparin-induced Thrombocytopenia And Thrombosis: Better Understanding Of Pathogenesis And Improving Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$653,137.00
Summary
Heparin, a widely used drug, can cause an adverse effect which results in a fall of the platelet count and the development of serious thrombosis. This drug complication is mediated by an immune mechanism. This proposal aims to provide a better understanding of the disease mechanism. It also aims to develop a new test that will improve the diagnosis, and to produce a novel drug that will effectively suppress the immune reaction and improve the treatment.
Development Of A New High Throughput Screen For Drug Binding To HERG K+ Channels
Funder
National Health and Medical Research Council
Funding Amount
$351,320.00
Summary
Inadvertent drug block of hERG, a potassium channel in the heart, can cause cardiac arrhythmias and sudden cardiac death. Screening for hERG toxicity has become a major hurdle for development of new drugs. We will use a mutant hERG protein that has enhanced drug binding to develop a high throughput test for hERG toxicity. Identification of dangerous drugs early in the drug discovery process will save the pharmaceutical industry millions of dollars in the costs of brining new drugs to market.
Drug-induced Immune Thrombocytopenia: Understanding The Disease Mechanisms Is The Key To Better Treatment
Funder
National Health and Medical Research Council
Funding Amount
$509,550.00
Summary
Many very commonly used medications cause an allergic reaction in a small number of patients that receive them. The allergic reaction results in platelets being destroyed and puts the patients at risk of bleeding. The patient recovers slowly if the drug is stopped but there is no other treatment and no way to reverse the effect quickly if the patient starts to bleed. This project will try to understand the mechanism of the condition and test a potential treatment.
Enhancing Direct Cu Recovery through Increased Gas Processing Understanding. This project aims to investigate mechanisms of copper loss during smelting and find new ways to reduce the loss. Smelting, which produces copper matte product and slag tailings, is an important step of the copper-making process from copper sulphides. The loss of copper to slag can be as high as 12 per cent. The project aims to create new knowledge about copper loss by matte droplets floated with gas bubbles generated by ....Enhancing Direct Cu Recovery through Increased Gas Processing Understanding. This project aims to investigate mechanisms of copper loss during smelting and find new ways to reduce the loss. Smelting, which produces copper matte product and slag tailings, is an important step of the copper-making process from copper sulphides. The loss of copper to slag can be as high as 12 per cent. The project aims to create new knowledge about copper loss by matte droplets floated with gas bubbles generated by chemical reactions to the slag phase. The outcomes are intended to enable copper smelters to maximise direct copper recovery, reduce copper production costs and increase the productivity of the smelting process.Read moreRead less
A Randomised Open-label Study Comparing The Safety And Efficacy Of Two Alternative Treatment Options In The Management Of HIV-1 Infected Participants Who Have Virologically Failed A Standard First-line Combination ART Regimen
Funder
National Health and Medical Research Council
Funding Amount
$457,676.00
Summary
For the past decade there has been an unprecedented international effort to provide access to care for all HIV-infected people as a basic human right. Most of these people are treated with a simple combination of drugs that are well proven to control HIV. However, what to do when this first drug combination stops working is unknown. This study aims to fill that knowledge gap so that patients failing the first drug combination can be offered a second combination with a maximal chance of success.
A revolution in Earth History: Life and Environment in the Neoarchaean (2.5-2.8 Ga). This research will keep Australian scientists in the forefront of studies of early life on Earth. At a time when there is a great deal of interest in this topic because of the search for similar life elsewhere in the Solar System, this work will take a prominant place in international research. It will attract leading researchers from elsewhere, with consequent intellectual benefits, and will inspire students t ....A revolution in Earth History: Life and Environment in the Neoarchaean (2.5-2.8 Ga). This research will keep Australian scientists in the forefront of studies of early life on Earth. At a time when there is a great deal of interest in this topic because of the search for similar life elsewhere in the Solar System, this work will take a prominant place in international research. It will attract leading researchers from elsewhere, with consequent intellectual benefits, and will inspire students to careers in science.Read moreRead less
A Phase III Trial Comparing Adjuvant Versus Salvage Radiotherapy For High Risk Patients Post Radical Prostatectomy
Funder
National Health and Medical Research Council
Funding Amount
$819,138.00
Summary
About half of all patients Treated with an operation to remove their prostate cancer have a high chance of the cancer coming back. Giving immediate radiotherapy to all patients will improve cure rates but does not benefit all men and can cause significant side effects. This study explores whether it is safe to wait and only give radiotherapy when there is a rising PSA after surgery indicating active cancer. A total of 470 men from Australasia will enter this study comparing the two approaches.
Where to find giant porphyry and epithermal gold and copper deposits. This project will determine when and where giant gold or copper deposits should form, consolidating links with Indonesia, and using South East Asia as a vast natural laboratory in which to examine the effect of large-scale tectonic processes. The project will produce a four-dimensional virtual exploration toolkit to show how to apply the methods.
Carbothermal synthesis of titanium carbide. The project's ultimate aim is to develop a comprehensive understanding of carbothermal reduction of titania and ilmenite for titanium carbide production. The projects findings will be of importance to improving the efficiency of carbothermal reduction processes, which are major technologies in ferrous metallurgy, and to the development of titanium industry in Australia.
Australia is the world largest producer of rutile and ilmenite, which are mainly s ....Carbothermal synthesis of titanium carbide. The project's ultimate aim is to develop a comprehensive understanding of carbothermal reduction of titania and ilmenite for titanium carbide production. The projects findings will be of importance to improving the efficiency of carbothermal reduction processes, which are major technologies in ferrous metallurgy, and to the development of titanium industry in Australia.
Australia is the world largest producer of rutile and ilmenite, which are mainly sold overseas and partly processed to titania pigment. Development of the cost-efficient technology for titanium carbide will stimulate a domestic production of this advanced material, what will add enormously to the value of titanium minerals.Read moreRead less