Defining Genetic And Epigenetic Variation During Early Development
Funder
National Health and Medical Research Council
Funding Amount
$996,075.00
Summary
We all began life with a set of genes inherited from our parents. However, it's now known that from the time we were in the womb onwards that genes can be turned off and on by the environment or even completely lost or gained. Even what your mother ate or how she behaved while she was pregnant could have influenced your future health. Because people are so different, we are studying the subtle differences between twins to tease out the factors that may influence our genes and our health.
Breast Cancer is a very common disease in women and although huge progress has been made in the last two decades, much remains to be done to improve our understanding of different types of breast cancer and its management. This program brings together the expertise of three senior researchers: 2scientists and 1 medical scientist. Dr Trench has an interest in identifying genes involved in cancers arising in patients who have a strong family history. She will use molecular methods and cohorts of p ....Breast Cancer is a very common disease in women and although huge progress has been made in the last two decades, much remains to be done to improve our understanding of different types of breast cancer and its management. This program brings together the expertise of three senior researchers: 2scientists and 1 medical scientist. Dr Trench has an interest in identifying genes involved in cancers arising in patients who have a strong family history. She will use molecular methods and cohorts of patients enrolled with Kathleen Cunningham Foundation for Research into Familial Breast and Ovarian Cancer to identify the genes responsible, assess their distribution in the population and determine whether these genes also play a role in non-familial cancers. Dr Khanna's work examines the complex array of enzymes that are responsible for maintaining the integrity of the DNA, and investigates how failure of these mechanisms leads to damage of the genetic material which ultimately results in cancer. It is known that genes involved in familial predisposition code for proteins that work as DNA repair enzymes. It is also known that different types of breast cancer exist, each with differing behaviour and response to treatment and that they are associated with specific genetic changes, including those associated with a familial predisposition. Prof Lakhani's interest lies in using microscopy and the latest molecular tools to refine the classification of these different types of breast tumour so that they can be managed appropriately by his surgical and oncological colleagues. A better understanding of the genetic changes and underlying biology of different types of breast cancer will lead to individualised and specific therapy for patients. This program brings together a unique combination, nationally and internationally, that investigates cancers at the level of genes and cells and translates the information to the clinic for the benefit of patient management.Read moreRead less
NATIONAL TRENDS IN SUICIDE BY AGE, GENDER, GEOGRAPHY, SOCIO-ECONOMIC AND MIGRANT STATUS AND MENTAL HEALTH
Funder
National Health and Medical Research Council
Funding Amount
$148,690.00
Summary
Suicide in Australia has become an increasingly important public health problem, chiefly because of increasing rates in some population sub-groups, and to a lesser extent because declines in other external causes of death have increased the prominence of suicide. Since the 1970s suicide rates have increased in young males and have eclipsed motor vehicle accidents as the dominant cause of death in this group. Suicide in the young produces a significant impact on years of life lost from premature ....Suicide in Australia has become an increasingly important public health problem, chiefly because of increasing rates in some population sub-groups, and to a lesser extent because declines in other external causes of death have increased the prominence of suicide. Since the 1970s suicide rates have increased in young males and have eclipsed motor vehicle accidents as the dominant cause of death in this group. Suicide in the young produces a significant impact on years of life lost from premature mortality. Suicide rates have been shown to vary by socio-economic status, ethnicity, area of residence, age and sex. In NSW for example, suicide rates in young males have been found to have increased by 50% in urban areas, and by 5-6 times in isolated rural areas. Another study has shown suicide rates to vary by country-of-birth which in turn has an effect on its relationship with socio-economic status. However, not all studies have replicated findings in NSW. In Queensland, for example, it has been shown that male youth suicide rates in rural areas have not substantially exceeded those in urban areas. There have been very few studies at the national level of variations in suicide in Australia. Most studies of Australian suicide to date have been confined to state-level analyses or to very limited nation-level analyses. An additional spur to a whole-nation approach to suicide has been the nation-wide Australian Bureau of Statistics Mental Health and Wellbeing Profile of Adults and a similar mental health survey of youth. Thus for the first time it will be possible to relate population prevalence of self-reported mental illness to suicide rates. In short, the current proposal addresses the two major gaps in Australia in population suicide research: examining suicide at the national level with regard to geographic location, immigrant and socio-economic status; and correlating surveyed prevalence of mental illness with suicide rates.Read moreRead less