Dissecting The Pseudoexfoliation Syndrome With Complementary Genetic, Proteomic And Biophysical Strategies
Funder
National Health and Medical Research Council
Funding Amount
$490,352.00
Summary
Pseudoexfoliation syndrome (PEX) is an eye condition in which flaky material deposits in the eye, greatly increasing the risk of cataract and glaucoma which can lead to blindness. PEX is also associated with heart disease, strokes and aneurysms. Cataract surgery in PEX patients has a higher rate of complications. In this project we will determine the nature of PEX material and why it forms. This knowlege will facilitate better diagnosis and treatment of PEX preventing associated blindness.
Identification And Characterisation Of Novel Genes For Congenital Cataract
Funder
National Health and Medical Research Council
Funding Amount
$432,750.00
Summary
Cataracts are the leading cause of blindness worldwide. The term describes a clouding of the lens which may lead to visual impairment. Congenital cataracts (present at birth) are less common than age-related cataract but the lifelong impact on vision can be severe, with a third of patients remaining legally blind. Late complications such as aphakic glaucoma may be blinding. We have shown that congenital cataracts are often inherited and have performed a population-based study in South-Eastern Au ....Cataracts are the leading cause of blindness worldwide. The term describes a clouding of the lens which may lead to visual impairment. Congenital cataracts (present at birth) are less common than age-related cataract but the lifelong impact on vision can be severe, with a third of patients remaining legally blind. Late complications such as aphakic glaucoma may be blinding. We have shown that congenital cataracts are often inherited and have performed a population-based study in South-Eastern Australia over the past 5 years to determine the causative genes. A large number of families have been involved in the study and solid progress has been made in identifying mutations in cataract genes and understanding what effect these may have on the patient's prognosis. We have recently identified a new gene in a large Australian family with a syndrome of cataract, mental retardation and teeth problems. This syndrome, known as Nance-Horan syndrome was originally described in Australia 30 years ago and we have worked with the original family to find the exact gene responsible. We already know that this gene causes the same syndrome in other families and in this project we will examine whether it can cause cataract without the other features or mental retardation without cataract. We will perform a series of experiments to learn what this gene does and how it causes the disease. We have also selected 3 other very interesting families with congenital cataracts for further study as we either know already or strongly suspect that they will enable us to identify further new genes for cataract, and in one case mental retardation. Our work in other diseases indicates that understanding the genes in severe young onset cases can give valuable clues to the causes of age-related forms and may in the future enable new ways to prevent and treat the commonest cause of worldwide blindness.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100174
Funder
Australian Research Council
Funding Amount
$380,000.00
Summary
Development of a digital Transmission Electron Microscope Facility in Tasmania. Development of a digital transmission electron microscope facility: Transmission electron microscopy is a fundamental tool for the study of biological systems at the ultrastructural level. This project will establish a facility that will be accessible to a range of biological researchers, replacing aged and non-sustainable electron microscopy facilities. The instrument will revitalise cellular research and provide ad ....Development of a digital Transmission Electron Microscope Facility in Tasmania. Development of a digital transmission electron microscope facility: Transmission electron microscopy is a fundamental tool for the study of biological systems at the ultrastructural level. This project will establish a facility that will be accessible to a range of biological researchers, replacing aged and non-sustainable electron microscopy facilities. The instrument will revitalise cellular research and provide additional insights and outcomes related to the study of intracellular features in a diverse range of systems and models. This will add substantially to the knowledge base across a wide range of fields of research, increasing national contributions in the areas of neuroscience, separation science and marine science.Read moreRead less
Threats to the water quality and ecosystem of Coffin Bay, South Australia. Coffin Bay (South Australia) is experiencing worsening environmental conditions despite its major economic and ecological importance. Research is needed to understand the cause of this decline, particularly in light of a recent bacterial outbreak that impacted the aquaculture industry. This multidisciplinary project aims to deliver world-leading scientific advice based on novel field techniques and innovative models of th ....Threats to the water quality and ecosystem of Coffin Bay, South Australia. Coffin Bay (South Australia) is experiencing worsening environmental conditions despite its major economic and ecological importance. Research is needed to understand the cause of this decline, particularly in light of a recent bacterial outbreak that impacted the aquaculture industry. This multidisciplinary project aims to deliver world-leading scientific advice based on novel field techniques and innovative models of this complex inverse estuary system and its surrounding catchment. The new understanding of the sources, fluxes and fate of nutrients within the bay and the surrounding catchment, arising from this project, is expected to benefit management decision-making and establish a new standard in estuarine water quality investigation.Read moreRead less
Putting death in its place. The project aims to link 890,000 population records to place of residence from 1838 to 1930, to examine the relationships between where people live, mortality, life expectancy and health. Where people live impacts their life-course outcomes. Using novel matching techniques, the project expects to identify intergenerational changes and the spatial dynamics of inequality and social mobility. Expected outcomes include the creation of a public resource of linked data and ....Putting death in its place. The project aims to link 890,000 population records to place of residence from 1838 to 1930, to examine the relationships between where people live, mortality, life expectancy and health. Where people live impacts their life-course outcomes. Using novel matching techniques, the project expects to identify intergenerational changes and the spatial dynamics of inequality and social mobility. Expected outcomes include the creation of a public resource of linked data and a better understanding of long-run health and inequality. These should provide economic and social benefits by informing policy aimed at contemporary social and health challenges, enhancing our understanding of Australian history, and developing public resources.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100929
Funder
Australian Research Council
Funding Amount
$462,948.00
Summary
Using ancient DNA to uncover climate change impacts on Antarctica. This project aims to utilise ancient DNA preserved in the seafloor to investigate how past Antarctic marine ecosystems have responded to past climatic changes, with a focus on the Holocene (last ~11,700 years). The study will generate the first-ever picture of marine community changes across the entire marine food web and unravel adaptation mechanisms of key marine organisms to climate shifts. Expected project outcomes will inclu ....Using ancient DNA to uncover climate change impacts on Antarctica. This project aims to utilise ancient DNA preserved in the seafloor to investigate how past Antarctic marine ecosystems have responded to past climatic changes, with a focus on the Holocene (last ~11,700 years). The study will generate the first-ever picture of marine community changes across the entire marine food web and unravel adaptation mechanisms of key marine organisms to climate shifts. Expected project outcomes will include significant knowledge advances into the evolution and resilience of Antarctic ecosystems over geological timescales. This will position Australia at the forefront of marine sedimentary ancient DNA research, and also provide valuable guidance for the conservation of Antarctica during ongoing climate change.Read moreRead less
An integrated tool for informing pest management: modelling range shifts for an invasive vertebrate in response to climate change. Invasive species and climate contribute directly to loss of biodiversity and economic productivity. This research project focuses on providing user-orientated tools that enable a strategic approach to European rabbit management and vertebrate pest control in Australia in response to anticipated climate and land-use change.
Industrial Transformation Training Centres - Grant ID: IC190100033
Funder
Australian Research Council
Funding Amount
$3,852,568.00
Summary
ARC Training Centre for Transformation of Australia's Biosolids Resource. This Centre aims to bring together Australia’s leading biosolids researchers and key industry and government stakeholders to advance the management, transformation and reuse of biosolids in agriculture. The focus is: 1) capability and knowledge building, 2) research development, extension and training, 3) sustainable strategic partnerships. The expected outcomes of the Centre are to develop a group of new, highly-trained i ....ARC Training Centre for Transformation of Australia's Biosolids Resource. This Centre aims to bring together Australia’s leading biosolids researchers and key industry and government stakeholders to advance the management, transformation and reuse of biosolids in agriculture. The focus is: 1) capability and knowledge building, 2) research development, extension and training, 3) sustainable strategic partnerships. The expected outcomes of the Centre are to develop a group of new, highly-trained industry-ready researchers as well as advanced solutions in three major themes: improved technologies, enhanced products and sustainability. This will provide significant benefits in the economic value of new applications and market opportunities as well as deliver cost-savings – all in an environmentally friendly manner.Read moreRead less
Capturing Proteus: 65 million years of ecosystem change revealed through evolution of Proteaceae in Australasia. By assessing past changes in the iconic Australian plant family Proteaceae, this research will show how the Australasian vegetation has responded to 65 million years of profound landscape and climate changes. This knowledge from the past will give important insights into how ecosystems can be expected to change under future climate scenarios.
Polymer nanoparticles and their assembled supracolloidal monolithic structures for applications in separation science. This project will generate new polymeric materials that will improve the analysis of complex samples. This will be applied in a wide range of areas of national importance including: pharmaceutical analysis and drug discovery; environmental, clinical and forensic analysis; and energy generation and foods.