Phase Variable Protein Glycosylation In Bacteria Mucosal Pathogens And Its Role In Immune Evasion
Funder
National Health and Medical Research Council
Funding Amount
$409,728.00
Summary
The bacterium Haemophilus influenzae is a leading cause of ear infections. Hearing loss from these infections can seriously affect literacy and educational performance. As no vaccine is available, we will research how the bacterium makes the HMW protein that is important in infection. We will study how sugars are added to the surface of this protein so that the bacterium can escape the immune system, its role in related bacteria and how it may be used in a vaccine.