Identification Of Glaucoma Susceptibility Variants By Exome Sequencing In Extended Pedigrees Showing Prior Evidence Of Gene Segregation.
Funder
National Health and Medical Research Council
Funding Amount
$694,002.00
Summary
Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for tr ....Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for treatment or diagnosis.Read moreRead less
Promoting employee mental health through the development of managers' psychological capital: A controlled field experiment. Depression significantly impacts Australian communities and costs the economy approximately 12 million days in lost productivity each year. By delivering a mental health promotion program to managers of small-medium enterprises, this study will enhance the psychological wellbeing and mental health literacy of managers in a sector of the business community often neglected in ....Promoting employee mental health through the development of managers' psychological capital: A controlled field experiment. Depression significantly impacts Australian communities and costs the economy approximately 12 million days in lost productivity each year. By delivering a mental health promotion program to managers of small-medium enterprises, this study will enhance the psychological wellbeing and mental health literacy of managers in a sector of the business community often neglected in occupational health research. The program targets managers within Tasmania, a setting representing regional communities in which people have a higher risk of mental ill-health problems. Read moreRead less
Discovery Indigenous Researchers Development - Grant ID: DI0240879
Funder
Australian Research Council
Funding Amount
$24,050.00
Summary
A Case Study Analysis of Indigenous Australian Entrepreneurs Exploring the Retention of Indigenous Values. The research project explores the possible changes or loss of cultural values on the Indigenous Australian Entrepreneurs from their involvement in founding and managing their own business. Does the Indigenous entrepreneur become in effect culturally non-indigenous whilst engaged in entrepreneurial activity? or, are the individuals cultural values maintained, transformed, subdued in some ot ....A Case Study Analysis of Indigenous Australian Entrepreneurs Exploring the Retention of Indigenous Values. The research project explores the possible changes or loss of cultural values on the Indigenous Australian Entrepreneurs from their involvement in founding and managing their own business. Does the Indigenous entrepreneur become in effect culturally non-indigenous whilst engaged in entrepreneurial activity? or, are the individuals cultural values maintained, transformed, subdued in some other context? These are the questions that this proposed research hopes to answer. The study is concerned with the connection between Anglo-European business values and general Indigenous cultural values. Little research has been published on Indigenous entrepreneurship; this project will fill a void in current literature in this area.Read moreRead less
The role of melting of oceanic crust within the subduction factory: A melt inclusion approach. Continental crust is ultimately generated in subduction zones, where oceanic crust is recycled back into the mantle along deep ocean trenches, producing island arcs. Processes occurring in the subduction 'factory' are poorly understood, but dehydration of old subducted oceanic crust is usually invoked to provide water that triggers mantle melting and arc magmatism. Evidence is accumulating that in many ....The role of melting of oceanic crust within the subduction factory: A melt inclusion approach. Continental crust is ultimately generated in subduction zones, where oceanic crust is recycled back into the mantle along deep ocean trenches, producing island arcs. Processes occurring in the subduction 'factory' are poorly understood, but dehydration of old subducted oceanic crust is usually invoked to provide water that triggers mantle melting and arc magmatism. Evidence is accumulating that in many locations the subducted oceanic crust may melt, rather than simply dehydrate. I will test this using studies of melt inclusions (droplets of melt trapped by crystals growing in the magma), and will better constrain the input-output budgets of the subduction factory.Read moreRead less
Phosphate stabilisation of metalliferous mine wastes: The key to solving a major environmental issue? Mine wastes represent the greatest proportion of solid waste produced by mankind. Unconstrained drainage from sulfide-rich mine wastes impacts on water, soil and sediment quality. This project will establish the scientific principles of phosphate stabilisation, which involves the addition of phosphate compounds to mine wastes and soils to permanently contain metals and acid. A solid understandin ....Phosphate stabilisation of metalliferous mine wastes: The key to solving a major environmental issue? Mine wastes represent the greatest proportion of solid waste produced by mankind. Unconstrained drainage from sulfide-rich mine wastes impacts on water, soil and sediment quality. This project will establish the scientific principles of phosphate stabilisation, which involves the addition of phosphate compounds to mine wastes and soils to permanently contain metals and acid. A solid understanding of this emerging technology is a prerequisite for any sustainable management of mine sites. The study will provide the foundation of future management tools needed by landholders, industry and regulators to remediate mined land and waste repositories.Read moreRead less
Transitions and Zoning in Porphyry-Epithermal Districts: Indicators, Discriminators, and Vectors. We aim to improve understanding of ore genesis and exploration success in porphyry-epithermal mineral districts. These districts can contain porphyry Cu-Mo-Au deposits (the world's major source of copper), epithermal Au-Ag deposits, skarn and sediment-hosted gold deposits. These districts continue to be important targets for copper and gold explorers, even though it can be difficult to identify th ....Transitions and Zoning in Porphyry-Epithermal Districts: Indicators, Discriminators, and Vectors. We aim to improve understanding of ore genesis and exploration success in porphyry-epithermal mineral districts. These districts can contain porphyry Cu-Mo-Au deposits (the world's major source of copper), epithermal Au-Ag deposits, skarn and sediment-hosted gold deposits. These districts continue to be important targets for copper and gold explorers, even though it can be difficult to identify the ore zones within large zones of background alteration. We will develop and test criteria that can be used by explorers to indicate prospective environments, discriminate between mineralization styles, and vector towards ore zones - be they of porphyry, epithermal, and/or other peripheral styles.Read moreRead less
Kimberlites and Flood Basalts: Linking Primary Melts with Mantle and Crustal Sources. Intimate relationships between kimberlites and diamonds, and between flood basalts and sulphide mineralisation make the study of deep mantle-derived magmas important to the scientific and exploration communities. The proposed research therefore represents a logical scientific step forward and is hence timely and important in this internationally competitive field, and serve as a training base for young research ....Kimberlites and Flood Basalts: Linking Primary Melts with Mantle and Crustal Sources. Intimate relationships between kimberlites and diamonds, and between flood basalts and sulphide mineralisation make the study of deep mantle-derived magmas important to the scientific and exploration communities. The proposed research therefore represents a logical scientific step forward and is hence timely and important in this internationally competitive field, and serve as a training base for young researchers keen to learn the techniques and methodologies involved. The possible outcomes of the project are of wide interest to geoscientists, and may benefit the Australian economy in that they help to predict whether the continental magmas and respective rocks have formed in parts of deep mantle with mineralisation potential.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100072
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
An x-ray scattering facility for advanced characterisation of natural and novel materials. This project will establish an analytical facility that will enable measurement of the atomic and finescale structure of materials. This facility will be used to help design novel materials for industrial, environmental and biomedical applications and to develop green technologies and processes for energy production and mining.
Powerful knowledge: mapping out standards of teachers' knowledge for teaching mathematics and English to achieve the goals of the curriculum. Setting standards is an important step to raising teacher quality. This project will establish benchmarks for teachers' knowledge at all levels of schooling in two key areas of the curriculum: English and mathematics.
Modelling with data: Advancing STEM in the primary curriculum. Improving the nation's skills in Science, Technology, Engineering, and Mathematics (STEM) remains a continuing concern, especially given the decline in international test results. The project aims to introduce a new approach to promoting this learning across grades 3-6 through modelling with data. With a focus on inquiry processes involving data variation and uncertainty within STEM-based contexts, the project aims to develop the imp ....Modelling with data: Advancing STEM in the primary curriculum. Improving the nation's skills in Science, Technology, Engineering, and Mathematics (STEM) remains a continuing concern, especially given the decline in international test results. The project aims to introduce a new approach to promoting this learning across grades 3-6 through modelling with data. With a focus on inquiry processes involving data variation and uncertainty within STEM-based contexts, the project aims to develop the important mathematical and statistical literacies needed for lifting student achievements. In advancing both theory and practice, the project aims to contribute to knowledge of primary students' capabilities for STEM problem solving and ways of enhancing implementation of the Australian Curriculum.Read moreRead less