Regulation Of Extrinsic Death Pathways In Neutrophils
Funder
National Health and Medical Research Council
Funding Amount
$84,656.00
Summary
During infection, the lifespan of neutrophils normally increases despite an abundance of neutrophil death signals in inflamed tissues. Altered lifespan of neutrophils has been reported in diseases associated with influenza, Streptococcus, RSV and cytomegalovirus infection. Our research has discovered a relationship between the two dominant death pathways in neutrophils, indicating that alterations in one death pathway protect the neutrophil from death signals from the second death pathway.
In spite of significant progress, inflammatory diseases remain poorly understood and difficult to treat and are of growing public health importance. This fellowship application is for translational research on improving treatment for inflammatory diseases, including rheumatoid arthritis. It will link the senior clinical appointments of Prof Ian Wicks in Rheumatology at the Royal Melbourne Hospital with his appointment as Head of the Inflammation Division at the Walter & Eliza Hall Institute of M ....In spite of significant progress, inflammatory diseases remain poorly understood and difficult to treat and are of growing public health importance. This fellowship application is for translational research on improving treatment for inflammatory diseases, including rheumatoid arthritis. It will link the senior clinical appointments of Prof Ian Wicks in Rheumatology at the Royal Melbourne Hospital with his appointment as Head of the Inflammation Division at the Walter & Eliza Hall Institute of Medical Research.Read moreRead less