Mobile DNA activity in the mammalian primordial germline. Early in pregnancy, a handful of cells in the embryo become primordial germ cells (PGCs). These PGCs will eventually give rise to sperm or egg cells, representing a critical inter-generational genetic link. Mobile DNA sequences target PGCs to create new heritable genetic changes. This proposal aims to analyse the activity, regulation, and consequences of mobile DNA activity in PGCs. This project expects to generate significant knowledge a ....Mobile DNA activity in the mammalian primordial germline. Early in pregnancy, a handful of cells in the embryo become primordial germ cells (PGCs). These PGCs will eventually give rise to sperm or egg cells, representing a critical inter-generational genetic link. Mobile DNA sequences target PGCs to create new heritable genetic changes. This proposal aims to analyse the activity, regulation, and consequences of mobile DNA activity in PGCs. This project expects to generate significant knowledge about the origins of mammalian genetic diversity. Expected outcomes include enhanced national and international collaborations across disciplines and new experimental systems. The expected benefit is an enhanced understanding of the mutational processes underlying genetic diversity and disease in mammals.Read moreRead less
Determining principles for successful episode retrieval of repeated events. This project aims to develop the first-ever set of explanatory principles for how people successfully retain and retrieve individual episode memories from repeated experiences (e.g., one occurrence of a routine social encounter or job-related activity). By deepening our understanding of how memory works, this new knowledge is expected to lay the foundation for interview guidance and ongoing research aimed at enhancing th ....Determining principles for successful episode retrieval of repeated events. This project aims to develop the first-ever set of explanatory principles for how people successfully retain and retrieve individual episode memories from repeated experiences (e.g., one occurrence of a routine social encounter or job-related activity). By deepening our understanding of how memory works, this new knowledge is expected to lay the foundation for interview guidance and ongoing research aimed at enhancing the proficiency of investigations into matters that rely on detailed and accurate accounts of specific episodes. This includes workplace or traffic accident investigations, infectious disease contact tracing, as well as prosecution of repeated sexual offences.Read moreRead less
Foundations of a good egg: correctly transitioning from mitosis to meiosis. Production of viable offspring is essential to the survival of any species. In all sexually reproducing species, this requires a unique cell type, the germ cell. Germ cells undergo a special type of cell division, called meiosis, so that they can eventually produce gametes (sperm in males and eggs in females). This project aims to discover how germ cells halt the standard form of cell division, called mitosis, and initia ....Foundations of a good egg: correctly transitioning from mitosis to meiosis. Production of viable offspring is essential to the survival of any species. In all sexually reproducing species, this requires a unique cell type, the germ cell. Germ cells undergo a special type of cell division, called meiosis, so that they can eventually produce gametes (sperm in males and eggs in females). This project aims to discover how germ cells halt the standard form of cell division, called mitosis, and initiate meiotic division instead. It is important to understand all the fundamental processes that occur during normal germ cell development so that, in the future, we can use this knowledge to support agricultural advances, rescue endangered species and solve human problems such as infertility and genetic disease.Read moreRead less
A new quality of life instrument with older people for economic evaluation. This project aims to develop and validate a new preference-based quality-of-life instrument with applications in aged-care. The new instrument will be developed with older people receiving aged care services, and will focus upon incorporating their values into the measurement and valuation of quality of life for economic evaluation. The new instrument will have immediate applications in quality assessment and economic ev ....A new quality of life instrument with older people for economic evaluation. This project aims to develop and validate a new preference-based quality-of-life instrument with applications in aged-care. The new instrument will be developed with older people receiving aged care services, and will focus upon incorporating their values into the measurement and valuation of quality of life for economic evaluation. The new instrument will have immediate applications in quality assessment and economic evaluation, improving the quality of life and wellbeing of older Australians, and will assist in determining the relative cost effectiveness of new and existing services.
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Mechanisms that control the inheritance of mitochondrial DNA mutations. How do humans and other organisms prevent the accumulation of dangerous mitochondrial genome (mtDNA) mutations across generations? This Project aims to uncover the cellular and molecular pathways that help prevent the inheritance of mtDNA mutations to offspring by employing cutting-edge genetic technologies that the laboratory has recently developed in the germline of an animal model system. This Project will generate new kn ....Mechanisms that control the inheritance of mitochondrial DNA mutations. How do humans and other organisms prevent the accumulation of dangerous mitochondrial genome (mtDNA) mutations across generations? This Project aims to uncover the cellular and molecular pathways that help prevent the inheritance of mtDNA mutations to offspring by employing cutting-edge genetic technologies that the laboratory has recently developed in the germline of an animal model system. This Project will generate new knowledge in the area of mitochondrial genetics and evolution. Expected outcomes include the development of new theories for mtDNA inheritance, which should provide significant benefits for agricultural breeding programs and the interpretation of mtDNA inheritance patterns in the human population.Read moreRead less
Attentional mechanisms in the relationship between sleep disruption and academic outcomes in Australian school children. This project will assess the impact of sleep problems on attention and academic performance in primary school children. The project will investigate typically developing children and children with developmental disorders over 18 months. The research will advance knowledge of the interplay between sleep, attention and learning across development.
Making nursing work: Developing a national framework for advanced practice in nursing. Advanced practice nursing (APN) is closing service gaps in delivery of health care across a range of settings for an aging population that is increasingly chronically ill. Development of APN has been rapid, resulting in confusion about the role and service potential. The lack of a common meaning of APN is prohibiting effective utilisation of the nursing workforce and causing confusion within nursing, the healt ....Making nursing work: Developing a national framework for advanced practice in nursing. Advanced practice nursing (APN) is closing service gaps in delivery of health care across a range of settings for an aging population that is increasingly chronically ill. Development of APN has been rapid, resulting in confusion about the role and service potential. The lack of a common meaning of APN is prohibiting effective utilisation of the nursing workforce and causing confusion within nursing, the health care industry and the community. The project aims to conduct the first nationwide study of advanced practice nurses, their clinical activities and service patterns. The research aims to develop new knowledge and professional tools and provide an evidence base for nursing workforce reform to meet the imperatives of contemporary health services.Read moreRead less
Morphological development of the kidney – a paradigm for organogenesis. This project aims to shed new light on how the kidney develops, how normal adult function is established and how congenital kidney malformations occur. It aims to investigate a mathematical pattern that has been discovered in the program of branching morphogenesis which dictates kidney development. By combining cutting-edge genetic approaches, morphological analysis and mathematical modelling, this project plans to explore h ....Morphological development of the kidney – a paradigm for organogenesis. This project aims to shed new light on how the kidney develops, how normal adult function is established and how congenital kidney malformations occur. It aims to investigate a mathematical pattern that has been discovered in the program of branching morphogenesis which dictates kidney development. By combining cutting-edge genetic approaches, morphological analysis and mathematical modelling, this project plans to explore how this pattern is established, how it dictates kidney development and whether it constitutes an ancient mechanism central to organ formation. Project outcomes may improve understanding of fundamental developmental processes and developmental disease and variation. Project findings may also be important for understanding the development of other organ systems.Read moreRead less
The initiation, development, and maintenance of alcohol/tobacco use in adolescents: The role of associative memory. Alcohol abuse and tobacco misuse are common in Australian adolescents and its long-term health consequences are well established. Models of drug-related memory association predict drug use in adults. However, memory association models have not been applied to smoking behaviour, or to understanding adolescent alcohol/tobacco use over time. It is expected that memory associations ....The initiation, development, and maintenance of alcohol/tobacco use in adolescents: The role of associative memory. Alcohol abuse and tobacco misuse are common in Australian adolescents and its long-term health consequences are well established. Models of drug-related memory association predict drug use in adults. However, memory association models have not been applied to smoking behaviour, or to understanding adolescent alcohol/tobacco use over time. It is expected that memory associations will predict the development of alcohol/tobacco use and misuse, after accounting for viable alternative explanations of the association. Understanding the role that memory associations have in the development of alcohol/tobacco use should inform prevention programs for at-risk adolescents.Read moreRead less
To imitate or innovate: A new look at children's social learning strategies. Children learn many important things by copying others. But how do we best facilitate this where it’s culturally appropriate or encourage innovation to support more general learning? This developmental psychology project aims to provide answers, using novel experiments and comparisons of different cultural groups to show how children acquire skills while becoming valued community members. Expected outcomes include the r ....To imitate or innovate: A new look at children's social learning strategies. Children learn many important things by copying others. But how do we best facilitate this where it’s culturally appropriate or encourage innovation to support more general learning? This developmental psychology project aims to provide answers, using novel experiments and comparisons of different cultural groups to show how children acquire skills while becoming valued community members. Expected outcomes include the refinement of core developmental psychology theory, introduction of new experimental techniques, and strengthening of international collaborations. This should provide significant benefits to educators, policy makers, parents and those invested in understanding and improving the inter-generational transmission of knowledge.Read moreRead less