PANDORA Wave 1: Assessment Of The Impact Of Maternal Diabetes On Growth And Nutritional Indicators, Cardio-metabolic Risk Factors And Developmental Risk Of Pre-school Aged Children Living In The Northern Territory.
Funder
National Health and Medical Research Council
Funding Amount
$122,714.00
Summary
Addressing the diabetes epidemic in the Indigenous Australian population requires early intervention. Early life is critical for long term risk of chronic disease but little is known regarding effective interventions, particularly for follow-up of children after a pregnancy complicated by diabetes. The project examines growth, body composition, and risk of developmental issues in children of mothers with and without diabetes in pregnancy, exploring risk factors for later chronic disease.
Improving The Design Of Pragmatic Clinical Trials In Children
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Whilst clinical research is designed to investigate interventions that improve patient health, to date, patients (including children) and their families have had no say in deciding what health outcomes matter most to them. The voices of patients and their families must be heard and used to inform how studies are designed if we are to achieve an improved model of health care and health service delivery. We propose to investigate and provide recommendations as to how this is best achieved.
A Comparison Of Arthroscopic Synovial Biopsy Based Targeted Biologic Therapy Versus Conventional Therapy In Rheumatoid Arthritis
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
This proposed study will investigate if treatment of rheumatoid arthritis (RA) based on biopsy of affected joints’ lining is better than standard therapy (not based on the results of biopsy). Current strategies to treat RA not infrequently result in incomplete disease suppression with potentially resultant joint damage, in part because of lack of definite guidelines to individualise treatment. We propose that therapy on the basis of the analysis of biopsy of joint lining will lead to better dise ....This proposed study will investigate if treatment of rheumatoid arthritis (RA) based on biopsy of affected joints’ lining is better than standard therapy (not based on the results of biopsy). Current strategies to treat RA not infrequently result in incomplete disease suppression with potentially resultant joint damage, in part because of lack of definite guidelines to individualise treatment. We propose that therapy on the basis of the analysis of biopsy of joint lining will lead to better disease control than the currently prevalent approach.Read moreRead less
Standardised Outcomes In Nephrology – Peritoneal Dialysis (SONG-PD): Establishing A Core Outcome Set In Peritoneal Dialysis
Funder
National Health and Medical Research Council
Funding Amount
$66,502.00
Summary
Standardised Outcomes in Nephrology-Peritoneal Dialysis study aims to establish a set of core outcomes for trials in PD based on the shared priorities of all stakeholders, so that outcomes of most relevance for decision making can be evaluated, and that interventions can be compared reliably.
Understanding Predictors Of Fatigue After Brain Injury In Children.
Funder
National Health and Medical Research Council
Funding Amount
$98,459.00
Summary
This research will examine what factors predict the fatigue children will experience after brain injury. This study is important because fatigue is one of the most commonly reported and challenging symptoms after traumatic brain injury. It significantly impacts on well being and quality of life after injury. We will assess fatigue of 120 children who suffer brain injury, from Toronto and Melbourne. This study will improve our understanding of the factors that predict fatigue following brain inju ....This research will examine what factors predict the fatigue children will experience after brain injury. This study is important because fatigue is one of the most commonly reported and challenging symptoms after traumatic brain injury. It significantly impacts on well being and quality of life after injury. We will assess fatigue of 120 children who suffer brain injury, from Toronto and Melbourne. This study will improve our understanding of the factors that predict fatigue following brain injury.Read moreRead less
Osteoporosis is a common problem with increased premature mortality associated with hip and even more minor fractures. The cause of increased mortality is debated although osteoporosis treatment may decrease this risk. This study will be the first to examine survival of all subjects in NSW admitted for a fracture including cause for subsequent hospitalisation and treatment taken. This study will help define the cause of the mortality and the role of anti osteoporosis treatment on outcome.
Anaemia In The Elderly: Epidemiology, Causes, Consequences And Optimal Transfusion Strategies
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Anaemia in the elderly (AE) is a common and increasing issue, which is often treated with blood transfusions. This project aims to investigate the causes and risk factors of patients who develop AE, and the impact of AE on health outcomes. The results will help define appropriate haemoglobin thresholds for AE, and provide information to develop appropriate guidelines for AE and transfusion management in the elderly.
Congenital aortic stenosis is a life-long condition caused by a narrowing of the aortic valve. It accounts for 2-6% of congenital heart disease, and if left untreated, results in heart failure and death. While several surgical and non-surgical interventions are available, the ideal treatment for this condition is unclear. My research aims to evaluate outcomes of aortic valve repair and compare it to other techniques.
Evaluating A Clinical Information Tool That Supports Patients’ Decision Making For Treatment Of End Stage Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$80,222.00
Summary
Chronic Kidney Disease is responsible for approximately 10% of deaths in Australia and this rate is increasing. There is also a growing number of people over 65 who are progressing to end stage kidney disease (ESKD). For some elderly people dialysis treatment may not be in their best interest. This research will develop and evaluate an evidence-based information tool to assist elderly people and their families in making appropriate decisions regarding treatment options in management of ESKD.