The Role Of The Peptide Urotensin II And Its Receptor In Diabetes Associated Vascular Complications
Funder
National Health and Medical Research Council
Funding Amount
$323,567.00
Summary
Diabetes damages blood vessels through the actions of hormones, possibly including new hormones such as urotensin II. I intend to investigate whether stopping the actions of urotensin II will prevent blood vessel and kidney damage in diabetes. By determining how urotensin II may cause the injury and thus prevent it from causing damage, I will be able to discover new targets for treatment that could reduce, or even prevent the progression of the blood vessel and kidney damage seen in diabetes.
The Role Of The Thioredoxin System In Angiogenesis And Impaired Neovascularisation In Diabetes Mellitus
Funder
National Health and Medical Research Council
Funding Amount
$306,501.00
Summary
For many sufferers of heart disease who suffer from blocked coronary arteries, current treatments (e.g. bypass surgery or angioplasty) are unable to offer relief from the debilitating effects of occluded arteries. This is particularly true of patients with diabetes who have more aggressive blockages. We plan to study a newly identified mechanism to facilitate growth of new blood vessels to sites affected by vascular disease . Ultimately, this may result in new treatments for heart disease.
Biomarkers And Genetic Determinants Of Cardiovascular Risk In Diabetes: The FIELD Study
Funder
National Health and Medical Research Council
Funding Amount
$1,961,718.00
Summary
The patient characteristics and blood factors determining the risk of heart attack, stroke, kidney and eye disease in people suffering from diabetes are not well understood. The FIELD Study, by analysing these characteristics and many blood factors hopes to shed light on ways to prevent these complications for future patients. The project proposes to measure factors on blood samples collected on more than 9000 patients with diabetes and analyse these over the next three years. It hopes to help d ....The patient characteristics and blood factors determining the risk of heart attack, stroke, kidney and eye disease in people suffering from diabetes are not well understood. The FIELD Study, by analysing these characteristics and many blood factors hopes to shed light on ways to prevent these complications for future patients. The project proposes to measure factors on blood samples collected on more than 9000 patients with diabetes and analyse these over the next three years. It hopes to help doctors identify patients who are at particular risk of complications for special attention and early treatment.Read moreRead less
Thioredoxin Interacting Protein: A Novel Regulator Of Angiogenesis And Impaired Neovascularisation In Diabetes Mellitus
Funder
National Health and Medical Research Council
Funding Amount
$292,639.00
Summary
Heart disease is the leading cause of death and treatment options such as bypass surgery are unsuitable for many sufferers, particularly those with diabetes. This project investigates the regulation of new blood vessel growth through the action of antioxidants and also examines the contribution of adult stem cells to this process. Regulating new blood vessel growth provides a novel means to overcome current problems in the management of both non-diabetic and diabetic patients with heart disease.