Comparing Einstein to Newton: a mathematical foundation for the Newtonian limit and post-Newtonian expansions. This proposal will benefit the nation in the following ways: (i) to make Australia a world leader in post-Newtonian research, (ii) to contribute to Australia's existing commitment to the search for gravitational waves by providing theoretical tools that will aid in the analysis of gravitational wave data, (iii) to train the next generation of Australian gravitational researchers in a fi ....Comparing Einstein to Newton: a mathematical foundation for the Newtonian limit and post-Newtonian expansions. This proposal will benefit the nation in the following ways: (i) to make Australia a world leader in post-Newtonian research, (ii) to contribute to Australia's existing commitment to the search for gravitational waves by providing theoretical tools that will aid in the analysis of gravitational wave data, (iii) to train the next generation of Australian gravitational researchers in a field whose importance will only grow as the field of gravitational wave astronomy matures, and (iv) to facilitate visits by my collaborators to Australia who will bring world class expertise for the benefit of both Australian students and experts in general relativity.Read moreRead less
Quantum Spectra. Fundamental quantum processes will play a key role in emerging technologies in the twenty-first century across diverse industries including quantum information technology, quantum computers and electronics, quantum optics, nanoscale quantum microscopes and superconductor technology. Australia has a strong base of expertise in the underpinning quantum disciplines. This project in strategic basic research within mathematical physics will develop a comprehensive and consistent math ....Quantum Spectra. Fundamental quantum processes will play a key role in emerging technologies in the twenty-first century across diverse industries including quantum information technology, quantum computers and electronics, quantum optics, nanoscale quantum microscopes and superconductor technology. Australia has a strong base of expertise in the underpinning quantum disciplines. This project in strategic basic research within mathematical physics will develop a comprehensive and consistent mathematical description of quantum processes. This research will lead to a deeper understanding of quantum processes, keep Australia at the leading edge of international developments and increase Australia's capacity to develop and implement these new technologies.Read moreRead less
Identifying Target Genes For Novel Anti-epileptic Therapies In The Mouse
Funder
National Health and Medical Research Council
Funding Amount
$469,802.00
Summary
Epilepsy is a disease which affects 2-4% of the population. There are a wide range of drugs available to treat the condition but there is consistently 30-40% of patients who do not respond well to any of these drugs and who continue to have seizures. The reason that there are no drugs available for these people is that most of the drugs available have been designed along the same principles. A new set of principles is needed to develop new drugs which will be able to treat those people not respo ....Epilepsy is a disease which affects 2-4% of the population. There are a wide range of drugs available to treat the condition but there is consistently 30-40% of patients who do not respond well to any of these drugs and who continue to have seizures. The reason that there are no drugs available for these people is that most of the drugs available have been designed along the same principles. A new set of principles is needed to develop new drugs which will be able to treat those people not responding to current therapy. This project is designed to identify new biologic pathways which may be interrupted with drugs to prevent seizures in people with epilepsy. This project uses a procedure to induce mutations into genes in mice and then screens for mice which do not seize when challenged with a drug which generates seizures in mice. Genetic studies will identify the mutated genes and these will be used as potential targets for new therapies or will identify new biological pathway which should expand the use of future anti-epileptic drugs.Read moreRead less
Energy, Cosmic Censorship and Black Hole Stability. Human progress is achieved by confronting fundamental questions, at the leading edge of knowledge. This project will lead to better understanding of space-time physics, and of the properties of singular solutions of non-linear hyperbolic equations. Such equations govern a wide range of physical phenomena, including fluid flow, weather and electromagnetic fields.
The Sakai scheme-Askey table correspondence, analogues of isomonodromy and determinantal point processes. The Australian mathematical sciences enjoys two research groups with active interests on Painleve equations in applied mathematics which are able to address difficult problems. Such a problem is to give a formulation of Sakai's 2001 classification of the Painleve equations in a form most suitable for applications. For this links will be made with a seemingly distinct area of mathematics - t ....The Sakai scheme-Askey table correspondence, analogues of isomonodromy and determinantal point processes. The Australian mathematical sciences enjoys two research groups with active interests on Painleve equations in applied mathematics which are able to address difficult problems. Such a problem is to give a formulation of Sakai's 2001 classification of the Painleve equations in a form most suitable for applications. For this links will be made with a seemingly distinct area of mathematics - the Askey table from the theory of hypergeometric orthogonal polynomials. A number of tractable PhD projects are suggested by this proposal.Read moreRead less
The shape of chaos: geometric advances in partially hyperbolic dynamics. This project aims to use recent advances in geometry and topology to discover new forms of chaotic dynamical systems and further classify the forms of chaos which are possible. Many systems in nature exhibit chaotic dynamics as they change in time. Not all systems are chaotic in the same way, and identifying the form of chaos and its qualitative properties is crucial to truly understanding the system. Chaotic dynamics aris ....The shape of chaos: geometric advances in partially hyperbolic dynamics. This project aims to use recent advances in geometry and topology to discover new forms of chaotic dynamical systems and further classify the forms of chaos which are possible. Many systems in nature exhibit chaotic dynamics as they change in time. Not all systems are chaotic in the same way, and identifying the form of chaos and its qualitative properties is crucial to truly understanding the system. Chaotic dynamics arise in chemical reactions, celestial mechanics, industrial mixing processes, fusion reactors, and many other processes. This project will aid in predicting the possible long-term behaviours of these systems.Read moreRead less
New Geometric and Entropy Techniques for Differential Equations. The three main practical outcomes of this mathematical research will be better predictability of salt movement responsible for land degradation, better predictability of surface evolution of microelectronic components in nanoscale technology and an open source computer package that harnesses new and powerful geometrical techniques to solve differential equations. The project will train the next generation of researchers in the math ....New Geometric and Entropy Techniques for Differential Equations. The three main practical outcomes of this mathematical research will be better predictability of salt movement responsible for land degradation, better predictability of surface evolution of microelectronic components in nanoscale technology and an open source computer package that harnesses new and powerful geometrical techniques to solve differential equations. The project will train the next generation of researchers in the mathematical modelling of critical physical processes and it will bring international experts to Australia to work on these vital problems.Read moreRead less
GEOMETRIC NUMERICAL INTEGRATION. Many scientific phenomena in physics, astronomy, and chemistry, are modelled by ordinary differential equations (ODEs). Often these equations have no solution in closed form, and one relies on numerical integration. Traditionally this is done using Runge-Kutta methods or linear multistep methods. In the last decade, however, we (and others) have discovered novel classes of so-called "geometric" numerical integration methods that preserve qualititative featur ....GEOMETRIC NUMERICAL INTEGRATION. Many scientific phenomena in physics, astronomy, and chemistry, are modelled by ordinary differential equations (ODEs). Often these equations have no solution in closed form, and one relies on numerical integration. Traditionally this is done using Runge-Kutta methods or linear multistep methods. In the last decade, however, we (and others) have discovered novel classes of so-called "geometric" numerical integration methods that preserve qualititative features of certain ODE's exactly (in contrast to traditional methods), leading to crucial stability improvements. Extending concepts from dynamical systems theory and traditional numerical ODEs, this project will improve, extend and systematize this new field of geometric integration.Read moreRead less
Geometric Integration. This project gives an important boost to Australia's strength in the niche area of geometric numerical integration,in the face of strong international competition. It gathers 7 world experts from 5 countries to create new computer programs to improve calculations in dynamics, with applications ranging from astronomy, physics, chemistry, biology, and meteorology to finance. It strengthens Australia's links with the mathematical software industry, and will lead to world-clas ....Geometric Integration. This project gives an important boost to Australia's strength in the niche area of geometric numerical integration,in the face of strong international competition. It gathers 7 world experts from 5 countries to create new computer programs to improve calculations in dynamics, with applications ranging from astronomy, physics, chemistry, biology, and meteorology to finance. It strengthens Australia's links with the mathematical software industry, and will lead to world-class graduates and research training.Read moreRead less
Geometric numerical integration of differential equations. Differential equations (DEs) play a central role in modelling scientific phenomena in physics, biology, chemistry, astronomy, meteorology, and geoscience. We have developed new ways of solving DEs, using geometric integration, which have significant advantages over traditional methods because of the crucial nonlinear stability they provide.
This project, combining 7 world experts from 6 countries and 1 early career researcher, will pl ....Geometric numerical integration of differential equations. Differential equations (DEs) play a central role in modelling scientific phenomena in physics, biology, chemistry, astronomy, meteorology, and geoscience. We have developed new ways of solving DEs, using geometric integration, which have significant advantages over traditional methods because of the crucial nonlinear stability they provide.
This project, combining 7 world experts from 6 countries and 1 early career researcher, will place Australia at the forefront of this intensive international activity.
It will significantly strengthen Australia's links with the mathematical software industry (e.g. Wolfram Research, Inc), and will lead to world class graduates and research training.
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