New Directions in Non-linear Mathematical Asymptotics. Major challenges such as predicting epidemics or modelling cancer rely on our understanding of simple mathematical models with extremely complicated solutions. The first and only model in the literature to reproduce the three-phase cycle of immune response in HIV/AIDS was based on cellular automata. Its results are extremely sensitive to infinitesimally small changes in parameters. Yet, no technique exists to study such variation in cellular ....New Directions in Non-linear Mathematical Asymptotics. Major challenges such as predicting epidemics or modelling cancer rely on our understanding of simple mathematical models with extremely complicated solutions. The first and only model in the literature to reproduce the three-phase cycle of immune response in HIV/AIDS was based on cellular automata. Its results are extremely sensitive to infinitesimally small changes in parameters. Yet, no technique exists to study such variation in cellular automata. This research will provide new methods for prediction and analysis of such models. Read moreRead less
A geometric theory for non-standard relaxation oscillators. This project aims to develop new geometric methods for the analysis of multi-scale models of biological rhythms, and design diagnostic tools to identify key parameters that cause and control these signals. Rhythms, such as breathing, neural and cardiac rhythms and pulsatile hormone secretion, are central for life. Many important biochemical cell signals exhibiting relaxation-type behaviour cannot be rigorously analysed with standard dy ....A geometric theory for non-standard relaxation oscillators. This project aims to develop new geometric methods for the analysis of multi-scale models of biological rhythms, and design diagnostic tools to identify key parameters that cause and control these signals. Rhythms, such as breathing, neural and cardiac rhythms and pulsatile hormone secretion, are central for life. Many important biochemical cell signals exhibiting relaxation-type behaviour cannot be rigorously analysed with standard dynamical systems tools due to an inherent non-uniform time-scale splitting in these models. This project aims to develop a unified mathematical theory that weaves together results from geometric singular perturbation theory and algebraic geometry to explain the genesis of complex rhythms and patterns in biological, non-standard, multi-scale systems, both at individual and network level.Read moreRead less
Geometric methods in mathematical physiology. This project will develop new geometric methods for the analysis of multiple-scales models of physiological rhythms and patterns, and will design diagnostic tools to identify key parameters that cause and control these signals. Thus, this project will deliver powerful mathematics for detecting and understanding fundamental issues of physiological systems.