Trials of numerous agents to slow the progression of Parkinsons disease have provided ambiguous or negative results despite having good preliminary evidence for their efficacy. The most likely reason is that many nerve cells are already destroyed by the time of diagnosis. Thus effective therapies may be most (and possible only) effective when administered in the presymptomatic stages of disease. This proposal is directed at developing method to detect early presymptomatic Parkinsons disease.
Mechanisms, Biomarkers And New Therapies For Abdominal Aortic Aneurysm
Funder
National Health and Medical Research Council
Funding Amount
$551,370.00
Summary
Approximately 5% of men and 1% of women aged over 60 years develop artery weakening. The management of artery weakening is currently focused on radiological imaging and surgery. In this fellowship work will be performed to better understand the mechanisms involved in artery weakening, assess new ways of monitoring disease progression and evaluate new medical therapies. It is envisaged that the work will identify a number of new management stratergies for this common condition.
Advances in positron emission tomography now allow specific pathological features of many brain diseases such as Alzheimer's disease to be measured with a brain scan during life. This Fellowship will assist Professor Rowe and his team in their world leading work on new PET scanning techniques to improve diagnosis and assist the development of treatment for Alzheimer's and other degenerative diseases of the brain.
Developing Improved Management For Peripheral Artery Diseases
Funder
National Health and Medical Research Council
Funding Amount
$569,219.00
Summary
~1 million Australians have peripheral artery disease. The current application is for a Practitioner Fellowship to support my research aimed at improving care of artery disease. The aim of the work is to develop improved management approaches for patients with blocked and weakened arteries. This work is particularly important given the recognised management deficiencies for patients with artery disease and the relative little research being undertaken in this area.
Understanding Early Life Risk Factors For Inflammation In The Rising Predisposition For NCDs
Funder
National Health and Medical Research Council
Funding Amount
$568,892.00
Summary
In 2011 the UN General Assembly identified the rise in non-communicable diseases (NCDs) as a major global threat, and prioritized preventive strategies against diseases like obesity, diabetes, heart disease, allergy and asthma. Common risk factors for these inflammatory diseases begin early in life, the most logical time for prevention. Our international interdisciplinary network aims to improve health and prevent NCDs by early interventions that reduce inflammation over the life-course.
Better Care Of Heart And Lung Disease For Aboriginal And Torres Strait Islander People In Rural And Remote Australia
Funder
National Health and Medical Research Council
Funding Amount
$380,583.00
Summary
Lung and heart disease are major contributors to the Aboriginal Australian and Torres Strait Islander health gap. This is even more so in remote and regional Australia. This Fellowship will generate new knowledge regarding how best to prevent, diagnose and treat heart and lung disease in this setting. Based in Alice Springs, it will bring together researchers and health care providers across northern and Central Australia and link them with our leading national research institutes.
In spite of significant progress, inflammatory diseases remain poorly understood and difficult to treat and are of growing public health importance. This fellowship application is for translational research on improving treatment for inflammatory diseases, including rheumatoid arthritis. It will link the senior clinical appointments of Prof Ian Wicks in Rheumatology at the Royal Melbourne Hospital with his appointment as Head of the Inflammation Division at the Walter & Eliza Hall Institute of M ....In spite of significant progress, inflammatory diseases remain poorly understood and difficult to treat and are of growing public health importance. This fellowship application is for translational research on improving treatment for inflammatory diseases, including rheumatoid arthritis. It will link the senior clinical appointments of Prof Ian Wicks in Rheumatology at the Royal Melbourne Hospital with his appointment as Head of the Inflammation Division at the Walter & Eliza Hall Institute of Medical Research.Read moreRead less
Brain Ageing - Studying Causes And Developing Interventions
Funder
National Health and Medical Research Council
Funding Amount
$481,156.00
Summary
This fellowship will assist in better understanding the complex reasons for serious conditions (dementia, stroke, falls, walking impairment) affecting brain health in ageing individuals, and in developing ways to reduce the risk or impact of these conditions in affected people.
Airway Inflammometry For Asthma And COPD: Practitioner Fellowship Peter G Gibson
Funder
National Health and Medical Research Council
Funding Amount
$568,892.00
Summary
Asthma and chronic obstructive pulmonary disease will receive the benefits of personalized medicine with this Fellowship funding. Dr Gibson, an international leader in this field, has identified key biomarkers that will allow treatments to be rationalized based on the underlying disease mechanisms. This research will translate the benefits on modern technology and apply these to individualized care for people with asthma and COPD, who can expect fewer lung attacks and better quality of life.
Identification And Early Treatment Of Autoimmune Brain Disease In Children
Funder
National Health and Medical Research Council
Funding Amount
$406,491.00
Summary
Acquired brain injury affects 2% of Australians, particularly young people, and can result in permanent disability. Most acquired brain injury is not reversible, however ‘autoimmune brain disease' is due to an overactive immune system and is treatable with modulation of the immune system. By measuring antibodies in the blood, this fellowship will result in early identification and treatment of autoimmune brain disease, and improve outcomes.