Methylation Sensitive Genes And The Transition To Allergic Disease: A Twin Study
Funder
National Health and Medical Research Council
Funding Amount
$493,843.00
Summary
Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in ....Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in children.Read moreRead less
Methylation-sensitive T Cell Genes And Childhood Food Allergy.
Funder
National Health and Medical Research Council
Funding Amount
$461,232.00
Summary
Australia has the highest reported prevalence food allergy in the world. Despite this, little is known about how allergy develops. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of food challenge proven food allergy with assessment of immune functioning & cutting edge genomics, to extensively characterise the pathways leading to food allergy in children.
Early Nutrition, Epigenetics And Developmental Outcomes In Children.
Funder
National Health and Medical Research Council
Funding Amount
$550,093.00
Summary
Increasing evidence demonstrates that early nutrition, including in pregnancy, has long lasting programming effects on later health of children. Evidence implicates epigenetics (literally ‘above DNA’) in mediating these effects. The most convincing data exists for obesity and related disorders such as metabolic syndrome, diabetes, and heart disease. The focus of this project is on understanding how ‘epigenetic’ mechanisms are influencing the way our genes function to cause these disorders.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100004
Funder
Australian Research Council
Funding Amount
$762,800.00
Summary
Ultrafast Infrared Spectroscopy Facility. The Ultrafast Infrared Spectroscopy Facility will provide a suite of techniques spanning the visible to mid-infrared spectral regions, on time scales corresponding to the emission of light, and energy conversion in low energy advanced functional materials. Research performed with this equipment will include photonic and thermal energy conversion; nanophotonics; quantum technologies and new infrared functional materials. This facility will enhance capacit ....Ultrafast Infrared Spectroscopy Facility. The Ultrafast Infrared Spectroscopy Facility will provide a suite of techniques spanning the visible to mid-infrared spectral regions, on time scales corresponding to the emission of light, and energy conversion in low energy advanced functional materials. Research performed with this equipment will include photonic and thermal energy conversion; nanophotonics; quantum technologies and new infrared functional materials. This facility will enhance capacity in probing new materials and devices in the near and mid-infrared regions, and will increase institutional and cross-disciplinary research collaboration.Read moreRead less
Nanowire infrared avalanche photodetectors towards single photon detection. This project aims to demonstrate semiconductor nanowire based infrared avalanche photodetectors (APDs) with ultra-high sensitivity towards single photon detection. By employing the advantages of their unique one-dimensional nanoscale geometry, the nanowire APDs can be engineered to different device architectures to achieve performance superior to their conventional counterparts. It is expected that this project will mak ....Nanowire infrared avalanche photodetectors towards single photon detection. This project aims to demonstrate semiconductor nanowire based infrared avalanche photodetectors (APDs) with ultra-high sensitivity towards single photon detection. By employing the advantages of their unique one-dimensional nanoscale geometry, the nanowire APDs can be engineered to different device architectures to achieve performance superior to their conventional counterparts. It is expected that this project will make significant contributions to the development of next generation high performance, fast speed, small size and low cost infrared photodetector technology platform enabling numerous emerging fields in modern transportation, communication, quantum computation and information processing to revolutionise our life and society.Read moreRead less
Nanophotonic tandem designs for high efficiency solar cells. This project will develop high-efficiency tandem solar cells that combine established silicon cell technology with novel low-cost thin-film solar cells. It will incorporate nanostructured layers between the cells that selectively trap different wavelengths of light, maximising light absorption in the top cell. This will make it possible to use a very thin top cell, reducing the requirements on electronic quality of the material. This p ....Nanophotonic tandem designs for high efficiency solar cells. This project will develop high-efficiency tandem solar cells that combine established silicon cell technology with novel low-cost thin-film solar cells. It will incorporate nanostructured layers between the cells that selectively trap different wavelengths of light, maximising light absorption in the top cell. This will make it possible to use a very thin top cell, reducing the requirements on electronic quality of the material. This project will also develop self-assembly techniques to enable the new nanostructures to be fabricated quickly and cheaply but with a high degree of control. Such cells will allow open the door to higher efficiencies, and lower costs, than is achievable with conventional solar cells.Read moreRead less
Ultrathin III-V Solar Cells via Crack-Assisted Layer Exfoliation. III-V semiconductors are excellent photovoltaic materials with highest demonstrated solar-to-electricity conversion efficiencies, but find limited usage in terrestrial applications due to high material and fabrication costs. This project aims to improve the cost-effectiveness of III-V solar cells by developing ultrathin III-V semiconductors via crack-assisted layer transfer approach and epitaxy-free fabrication via heterojunction ....Ultrathin III-V Solar Cells via Crack-Assisted Layer Exfoliation. III-V semiconductors are excellent photovoltaic materials with highest demonstrated solar-to-electricity conversion efficiencies, but find limited usage in terrestrial applications due to high material and fabrication costs. This project aims to improve the cost-effectiveness of III-V solar cells by developing ultrathin III-V semiconductors via crack-assisted layer transfer approach and epitaxy-free fabrication via heterojunction architectures, paving the way for cost-effective, high-efficiency, flexible solar cells. The expected outcomes include a disruptive technology for integrated photovoltaics, novel contact and passivation materials, as well as new knowledge generated in materials science and optoelectronics disciplines.Read moreRead less
Uncovering The Basis Of Inflammatory And Immunodeficiency Diseases
Funder
National Health and Medical Research Council
Funding Amount
$15,718,075.00
Summary
A world-class team from 3 institutions, spanning disciplines of clinical and experimental immunology, therapeutics, signalling and genetics, will identify how immune and inflammatory responses are controlled in both health and disease. The major outcomes of this work will be the generation of new knowledge, concepts and approaches to diagnose, prevent and treat the major human health problems of autoimmune diseases, inflammation, allergy and immunodeficiency.
It is feasible to sequence patient genomes but we need to know more about how genetic variants cause complex disease. We have sequenced genomes from patients with immune deficiency and will test the idea that genetic variation causes consistent changes in particular white blood cells, thus providing a bridge between genomic information and clinical diagnosis. Outcomes will include more accurate diagnosis, better understanding of immunity, and a strategy for using whole genome information.
Nanophotonics for strong absorption in extremely thin solar cells: moving beyond silicon. This project will lead to the development of extremely thin solar cells made of novel low-cost materials, which would likely reduce the cost of photovoltaic technology. If the cost of photovoltaics was sufficiently low then it could have a major impact on reducing greenhouse gas emissions and pollution in Australia and worldwide.