A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interac ....A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interactions, which will greatly complement existing meta-omics approaches. The deliverables include a proof-of-concept system validated for gut-liver axis as well as the creation of new knowledge and framework to assimilate design thinking and advanced manufacturing to elevate tissue engineering into physiology engineering. Read moreRead less
Liquids to semiconductors: the formation of solution-processed electronics. This project aims to understand and control the formation of solution-processed organic semiconductors. This project will create unique experimental methodologies to study, in situ, the evolution of the structure and the emergence of electrical transport all the way from the initial solution to the final film. These findings will be used to formulate design rules and principles that will accelerate the development of sol ....Liquids to semiconductors: the formation of solution-processed electronics. This project aims to understand and control the formation of solution-processed organic semiconductors. This project will create unique experimental methodologies to study, in situ, the evolution of the structure and the emergence of electrical transport all the way from the initial solution to the final film. These findings will be used to formulate design rules and principles that will accelerate the development of solution-processed semiconductors beyond current trial-and-error approaches. This will provide significant benefits, such as unlocking the potential of soft and flexible semiconductors for new technologies based on sustainable manufacturing.Read moreRead less
ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to unde ....ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to understand how single cells react to and communicate with their surroundings. This science will underpin a new generation of devices capable of probing the response of cells within individuals to environmental conditions or treatment, creating innovative and powerful new sensing platforms.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100030
Funder
Australian Research Council
Funding Amount
$541,705.00
Summary
National facility for nanoscale characterisation of luminescent materials. The project aims to establish a national facility for nanoscale characterisation of advanced optoelectronic materials, including atomically-thin materials, luminescent nanocrystals, metamaterials, and plasmonic nanostructures. The combination of a highly focused electron beam, and novel light detection optics, will enable temperature-dependent, angle, polarisation and time-resolved luminescence analysis with unprecedented ....National facility for nanoscale characterisation of luminescent materials. The project aims to establish a national facility for nanoscale characterisation of advanced optoelectronic materials, including atomically-thin materials, luminescent nanocrystals, metamaterials, and plasmonic nanostructures. The combination of a highly focused electron beam, and novel light detection optics, will enable temperature-dependent, angle, polarisation and time-resolved luminescence analysis with unprecedented resolution. It is expected this will yield discoveries in nanoscale physics and materials science. It will create interdisciplinary collaborations by linking Australian scientists who use high-resolution multimodal characterisation methods to innovate and develop materials and device technologies.Read moreRead less
Non-classical motion of a macroscopic mechanical resonator. This project will create the experimental tools to fully control the motion of a mechanical oscillator at the single-quanta level, opening a rich avenue for fundamental research and the development of quantum physics enhanced applications. This project will prepare a quantum state of a macroscopic mechanical resonator exhibiting quantum interference fringes at at an unprecedented mass scale. The observation of these fringes will enable ....Non-classical motion of a macroscopic mechanical resonator. This project will create the experimental tools to fully control the motion of a mechanical oscillator at the single-quanta level, opening a rich avenue for fundamental research and the development of quantum physics enhanced applications. This project will prepare a quantum state of a macroscopic mechanical resonator exhibiting quantum interference fringes at at an unprecedented mass scale. The observation of these fringes will enable the study of the intricacies of quantum decoherence and ultimately even probe quantum gravitational phenomena. To achieve these goals it will employ micro-scale optical resonators fabricated by established techniques, that also provide the ideal platform for scalable mechanical-oscillator-based quantum information applications.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100934
Funder
Australian Research Council
Funding Amount
$439,082.00
Summary
Taming the light: full control in polarisation, space, and time. This project aims to develop two prototype optical beam shaping systems, culminating in the demonstration of new high-power optical fibre amplifiers. This novel ability to control all the properties of light enables the generation of optical beams that were only theoretical ideas but never previously implemented experimentally. This advanced technology can potentially open new ways in which objects can be probed using light. Expect ....Taming the light: full control in polarisation, space, and time. This project aims to develop two prototype optical beam shaping systems, culminating in the demonstration of new high-power optical fibre amplifiers. This novel ability to control all the properties of light enables the generation of optical beams that were only theoretical ideas but never previously implemented experimentally. This advanced technology can potentially open new ways in which objects can be probed using light. Expected outcomes include the creation of an optical platform that the optical community at large may utilise for their specific applications. Besides the intellectual property benefits of such optical devices directly, this project should bridge the gap between the developed knowledge and commercial opportunities.Read moreRead less
Control of light in space and time in multimode optical fibres. This project aims to create devices to measure and manipulate the spatial and temporal properties of light. The ability to control or measure the spatial and/or temporal properties of light is a fundamental feature of many applications, including biomedical imaging, astronomy, telecommunications, high-power lasers and quantum computing. This project will develop five prototype systems to control the spatiotemporal properties of ligh ....Control of light in space and time in multimode optical fibres. This project aims to create devices to measure and manipulate the spatial and temporal properties of light. The ability to control or measure the spatial and/or temporal properties of light is a fundamental feature of many applications, including biomedical imaging, astronomy, telecommunications, high-power lasers and quantum computing. This project will develop five prototype systems to control the spatiotemporal properties of light in ways that were previously not possible. This would affect fundamental and applied applications where the inability to sufficiently control light’s spatial and/or temporal properties is an impediment. Examples include imaging deep into ‘opaque’ objects such as human skin or brain, high-power lasers for material processing and manufacturing, optical telecommunications and quantum computation.Read moreRead less
Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most importa ....Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most important mechano-sensor implicated in cell adhesion, migration, growth and survival. Specifically, it integrates nationally unique cutting-edge techniques including single-molecule force probe, microparticle image velocimetry, microfluidics and molecular dynamics simulation, super resolution and 3D volumetric imaging modalities.Read moreRead less
High shear fluid flow driving carbon foundry for advanced manufacturing. This project aims to develop versatile continuous flow thin film microfluidic device technology for harnessing contact electrification generated by sub-micron high shear flows in fabricating novel and high-performance nano-carbons for which current methods are ineffective or impossible. This project expects to generate new knowledge on complex vortex fluid fields, their intricate interactions with external electric and magn ....High shear fluid flow driving carbon foundry for advanced manufacturing. This project aims to develop versatile continuous flow thin film microfluidic device technology for harnessing contact electrification generated by sub-micron high shear flows in fabricating novel and high-performance nano-carbons for which current methods are ineffective or impossible. This project expects to generate new knowledge on complex vortex fluid fields, their intricate interactions with external electric and magnetic fields and carbon nanostructure formation. Expected outcomes for this project include exquisite control on reforming nanocarbon with tuneable properties and unprecedented hetero-structures. This should provide significant benefits, such as in generating new processes and products for advanced manufacturing. Read moreRead less
Creating a non-invasive window into the mind. This project aims to create better tools to study the human mind. This project expects to generate new knowledge that can be used to non-invasively image neuronal activity. Expected outcomes include the development of unique new Magnetic Resonance Imaging (MRI) instruments to study neuronal activity in both highly controlled laboratory conditions and in humans, with the spatial and temporal resolution needed to study the neuronal circuitry that drive ....Creating a non-invasive window into the mind. This project aims to create better tools to study the human mind. This project expects to generate new knowledge that can be used to non-invasively image neuronal activity. Expected outcomes include the development of unique new Magnetic Resonance Imaging (MRI) instruments to study neuronal activity in both highly controlled laboratory conditions and in humans, with the spatial and temporal resolution needed to study the neuronal circuitry that drives low and high-level brain functions, i.e., creating a window into the mind. In the future, outcomes from this study could improve our understanding of mental disorders, advance computer brain interface technology, and inspire the next paradigm shift in artificial intelligence.Read moreRead less