The Role Of Nuclear Architecture In The DNA Damage Response
Funder
National Health and Medical Research Council
Funding Amount
$561,966.00
Summary
The goal of the proposed research is to understand how dynamic changes to the chromatin genome packaging network, interact with the DNA damage response and gene expression machinery, to repair damaged DNA and the impact this has on cancer biology. To do so we are combining cutting edge molecular biology techniques with innovative novel microscopy methods developed by our research team, that far exceed the spatiotemporal resolution currently used to study chromatin biology.
On the mechanism of boiling instability in microchannels. This project will enable designers to create highly efficient miniaturised devices based on the boiling of fluids such as water or organics. These devices include micro-power generation systems, coolers for computer chips and solar collectors, and micro-chemical process systems. Such devices provide environmental, safety and economic benefits.
How Replication Stress Activates The Mitotic Telomere DNA Damage Response To Kill Cancer Cells
Funder
National Health and Medical Research Council
Funding Amount
$486,467.00
Summary
We discovered a novel mechanism linking stress during DNA replication to difficulties with the cell division process, and identified how this turns on DNA damage response signals from the chromosome ends (i.e. “telomeres”). We have further identified that we can exploit this mechanism to kill cancer cells. In this project we will explore this newly discovered mechanism and identify how it can be targeted for therapeutic purposes.
Heat Transfer Characteristics of Biological Tissues with Nanoparticles. Heat transfer of laser-irradiated nanoparticles in biological tissues requires a basic knowledge of the unique strong resonance absorption properties and a fundamental understanding of the thermal and chemical conversions as a consequence of these heated nanoparticles. This project aims to investigate the extent of the non-equilibrium heating effects of heated nanoparticles on the destruction of biological tissues. Comprehen ....Heat Transfer Characteristics of Biological Tissues with Nanoparticles. Heat transfer of laser-irradiated nanoparticles in biological tissues requires a basic knowledge of the unique strong resonance absorption properties and a fundamental understanding of the thermal and chemical conversions as a consequence of these heated nanoparticles. This project aims to investigate the extent of the non-equilibrium heating effects of heated nanoparticles on the destruction of biological tissues. Comprehensive experimental studies and computational modelling to be performed are expected to significantly enhance the understanding of laser-induced heating phenomena of embedded nanoparticles in biological tissues and the prediction of the level of destruction that can be experienced by these heated nanoparticles.Read moreRead less
Design and Optimisation of Novel Enthalpy Heat Exchangers. This project deals with the thermal design and optimisation of a novel type of latent energy heat exchanger. This new heat exchanger overcomes the practical implementation problems of previous latent energy heat exchangers such as heat-wheels. The main application of this innovative heat exchanger will be to improve the capacity and efficiency of air conditioning systems. As the new heat exchanger is very compact it will be ideally sui ....Design and Optimisation of Novel Enthalpy Heat Exchangers. This project deals with the thermal design and optimisation of a novel type of latent energy heat exchanger. This new heat exchanger overcomes the practical implementation problems of previous latent energy heat exchangers such as heat-wheels. The main application of this innovative heat exchanger will be to improve the capacity and efficiency of air conditioning systems. As the new heat exchanger is very compact it will be ideally suited for integration with air conditioning coils. Existing latent heat wheels are very bulky and are difficult to integrate into standard air conditioner installations.Read moreRead less
Deciphering The Role Of Atypical DNA Methylation In Neuronal Genome Regulation And Neurological Disorders
Funder
National Health and Medical Research Council
Funding Amount
$773,484.00
Summary
This research will use a combination of genomic, biochemical and functional genomics approaches to investigate the role of the atypical mCH form of DNA methylation in neuronal genome regulation and function, and provide new insights into the role of the epigenome in healthy brain function and neural pathologies.
Solving Delivery Of Gene Therapy For Control Of Human Immunodeficiency Virus Infection
Funder
National Health and Medical Research Council
Funding Amount
$765,439.00
Summary
Antiretroviral therapy free control of Human Immunodeficiency Virus (HIV) infection requires control of the viral reservoir. We have a unique approach, aimed at enforcing HIV latency by targeting highly conserved regions in the viral promoter. These constructs completely silence viral transcription for long periods of time. We intend to develop & assess vectors that are specifically targeted to the reservoir and which can enforce viral latency despite immune activation or viral variation.
Design of high performance heat sink composites. Heat sink composites are advanced materials that have the very substantial but widely untapped potential to reduce Society's energy consumption by means of utilizing waste energy or through energy-efficient temperature control. This Project uses computational analysis and parallel experimentation to design optimum heat-sink composites for highly energy-efficient temperature control of chemical batteries or electronic components as well as the mean ....Design of high performance heat sink composites. Heat sink composites are advanced materials that have the very substantial but widely untapped potential to reduce Society's energy consumption by means of utilizing waste energy or through energy-efficient temperature control. This Project uses computational analysis and parallel experimentation to design optimum heat-sink composites for highly energy-efficient temperature control of chemical batteries or electronic components as well as the means for the efficient heating/cooling of buildings. The outcomes of the project will lay the scientific foundation for the industrial scale development of advanced heat sinks that will lower energy costs and decrease climate changing emissions. This represents a new market for Australian industry.Read moreRead less
Epigenetic Changes In The Prostate Cancer Microenvironment
Funder
National Health and Medical Research Council
Funding Amount
$848,954.00
Summary
Many men with prostate cancer have slow-growing tumours that are unlikely to spread outside the prostate. These men with low-risk cancer are often monitored to prevent unnecessary aggressive treatments. However, the current methods used to distinguish between slow-growing and aggressive tumours are imprecise and there is a risk of missing aggressive tumours. We aim to identify new biomarkers of prostate cancer by measuring modifications to the DNA in the tumour and surrounding cells
Circulating Tumour DNA To Monitor Treatment Response And Resistance In Chronic Lymphocytic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$876,950.00
Summary
Many cancers shed small amounts of DNA (ctDNA) into the patient’s bloodstream and recent advances in genomic technologies now allow levels of ctDNA to be accurately measured in the blood. Changes in ctDNA levels have potential to be used as specific markers of disease progression and/or response to cancer therapy. This project will evaluate if ctDNA can be used to monitor treatment responses and individualise treatment decisions in patients with chronic lymphocytic leukaemia.