Methylation-sensitive T Cell Genes And Childhood Food Allergy.
Funder
National Health and Medical Research Council
Funding Amount
$461,232.00
Summary
Australia has the highest reported prevalence food allergy in the world. Despite this, little is known about how allergy develops. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of food challenge proven food allergy with assessment of immune functioning & cutting edge genomics, to extensively characterise the pathways leading to food allergy in children.
Methylation Sensitive Genes And The Transition To Allergic Disease: A Twin Study
Funder
National Health and Medical Research Council
Funding Amount
$493,843.00
Summary
Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in ....Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in children.Read moreRead less
Early Nutrition, Epigenetics And Developmental Outcomes In Children.
Funder
National Health and Medical Research Council
Funding Amount
$550,093.00
Summary
Increasing evidence demonstrates that early nutrition, including in pregnancy, has long lasting programming effects on later health of children. Evidence implicates epigenetics (literally ‘above DNA’) in mediating these effects. The most convincing data exists for obesity and related disorders such as metabolic syndrome, diabetes, and heart disease. The focus of this project is on understanding how ‘epigenetic’ mechanisms are influencing the way our genes function to cause these disorders.
Researching the Social Role of Religions in Australia. Most Australians claim allegiance to various religions in the Census. The number of religious denominations has greatly increased in recent years, most notably through immigration, with significant numbers from all world religions. Political and social policies are frequently influenced by religious principles and a detailed analysis of this variety is of crucial national importance. Religions from neighbouring societies are significantly r ....Researching the Social Role of Religions in Australia. Most Australians claim allegiance to various religions in the Census. The number of religious denominations has greatly increased in recent years, most notably through immigration, with significant numbers from all world religions. Political and social policies are frequently influenced by religious principles and a detailed analysis of this variety is of crucial national importance. Religions from neighbouring societies are significantly represented in Australia. Understanding them is of central importance in international political and commercial activity. Current research is essential, based on the most recent Census and other recent socio-economic information.
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What makes for successful numeracy education in remote Indigenous contexts: an ethnographic case study approach. There are many successful teachers and schools who have enabled remote Indigenous learners to engage with, and learn, school mathematics. But what do they do? How do they do it? This project investigates and documents successful practices in 32 schools located in remote communities. The project includes the many aspects of teaching practice.
The endangered swift parrot as a model for managing small migratory birds. Endangered swift parrots use variable locations while breeding in eastern Tasmania and over winter on the Australian mainland. This project aims to develop effective conservation strategies for swift parrots and other migrants using new and long term data and innovative technological solutions to tracking small birds across vast landscapes.
Processing mathematics tasks: the nature and role of visual and non-visual reasoning in digital and non-digital environments. Within the next four years, it is likely that the National Assessment Plan for Literacy and Numeracy (NAPLAN) will be administered in a digital mode. This project identifies differences between the delivery of mathematics assessment in pencil-and-paper and computer-based modes. Primary students' mathematics reasoning is compared across these modes and to cohorts from Sing ....Processing mathematics tasks: the nature and role of visual and non-visual reasoning in digital and non-digital environments. Within the next four years, it is likely that the National Assessment Plan for Literacy and Numeracy (NAPLAN) will be administered in a digital mode. This project identifies differences between the delivery of mathematics assessment in pencil-and-paper and computer-based modes. Primary students' mathematics reasoning is compared across these modes and to cohorts from Singapore.Read moreRead less
Processing dynamic graphics: Visuospatial reasoning in mathematics. Increasingly, mathematics competence will be measured in digital and dynamic contexts. Students who possess high visuospatial reasoning are expected to become even better equipped to succeed in science, technology, engineering and mathematics (STEM) related disciplines as technological advances shape how we interpret and decode information. This project explores those aspects of visuospatial reasoning critical for success when s ....Processing dynamic graphics: Visuospatial reasoning in mathematics. Increasingly, mathematics competence will be measured in digital and dynamic contexts. Students who possess high visuospatial reasoning are expected to become even better equipped to succeed in science, technology, engineering and mathematics (STEM) related disciplines as technological advances shape how we interpret and decode information. This project explores those aspects of visuospatial reasoning critical for success when students encounter dynamic mathematics tasks, and attempts to determine whether different forms of visuospatial reasoning are required to decode static and dynamic information. The project aims to better understand how students process mathematics tasks, so the inevitable move toward digital assessment can be managed effectively to promote assessment for learning.Read moreRead less
Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outco ....Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outcomes include innovative genetic rescue protocols, a framework for genetic rescue, and leading-edge conservation training. Expected benefits are increased persistence of species that are otherwise unresponsive to management, and a new path to saving endangered species.Read moreRead less
Social and geographical location and its impact on mathematics teaching and learning. Too many students from poor urban backgrounds or from rural communities are at risk of underperforming in school mathematics. This project identifies the critical factors that contribute to this failure and seeks to develop improved practices to enable greater access to school mathematics.