How Replication Stress Activates The Mitotic Telomere DNA Damage Response To Kill Cancer Cells
Funder
National Health and Medical Research Council
Funding Amount
$486,467.00
Summary
We discovered a novel mechanism linking stress during DNA replication to difficulties with the cell division process, and identified how this turns on DNA damage response signals from the chromosome ends (i.e. “telomeres”). We have further identified that we can exploit this mechanism to kill cancer cells. In this project we will explore this newly discovered mechanism and identify how it can be targeted for therapeutic purposes.
Ubiquitin And SUMO DNA Damage Response Signalling At Deprotected Telomeres During The Cell Cycle
Funder
National Health and Medical Research Council
Funding Amount
$302,627.00
Summary
Following genome damage cells stop the cell division process and initiate DNA repair. We discovered that at specific times during cell division his does not happen if the damage signals originate from the chromosome ends (i.e. “telomeres”). We anticipate this is necessary to prevent genomic instability in healthy cells and may be driving genomic instability in cancer cells. Experiments described here will elucidate the molecular mechanisms and biological significance of our observation.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100030
Funder
Australian Research Council
Funding Amount
$270,000.00
Summary
Test-bed for Wide-Area Software Defined Networking Research. Test bed for wide-area software defined networking research: This project aims to develop a wide-area test bed, spanning ten organisations, for conducting research and experimentation in the emerging disruptive technology of Software Defined Networking (SDN). SDN is likely to bring long-term transformation to the networking industry, much like cloud computing did, by enabling dynamic virtualised elastic network services under software ....Test-bed for Wide-Area Software Defined Networking Research. Test bed for wide-area software defined networking research: This project aims to develop a wide-area test bed, spanning ten organisations, for conducting research and experimentation in the emerging disruptive technology of Software Defined Networking (SDN). SDN is likely to bring long-term transformation to the networking industry, much like cloud computing did, by enabling dynamic virtualised elastic network services under software control. The test bed will empower Australian researchers in network technologies and dependent applications (for example, multimedia and security) to collaboratively develop and demonstrate novel ideas at scale. This is expected to benefit Australia by giving our researchers international recognition in this nascent area, and developing a national talent pool for local industry.Read moreRead less
Object-based motion estimation for highly efficient streaming video. This project aims to develop motion and shape estimation tools that allow video content to be predicted at any point in time using frame data that is available at other points in time. Applications of this include video coding, frame synthesis for temporal re-sampling. The project expects to develop algorithms for jointly estimating compact motion and shape descriptions of video content. These descriptions will allow quality re ....Object-based motion estimation for highly efficient streaming video. This project aims to develop motion and shape estimation tools that allow video content to be predicted at any point in time using frame data that is available at other points in time. Applications of this include video coding, frame synthesis for temporal re-sampling. The project expects to develop algorithms for jointly estimating compact motion and shape descriptions of video content. These descriptions will allow quality refinement by progressively adding spatial and temporal detail. It is expected that these compact descriptions will lead to significantly more flexible and efficient transmission of video content over modern communications networks.Read moreRead less
The Role Of Nuclear Architecture In The DNA Damage Response
Funder
National Health and Medical Research Council
Funding Amount
$561,966.00
Summary
The goal of the proposed research is to understand how dynamic changes to the chromatin genome packaging network, interact with the DNA damage response and gene expression machinery, to repair damaged DNA and the impact this has on cancer biology. To do so we are combining cutting edge molecular biology techniques with innovative novel microscopy methods developed by our research team, that far exceed the spatiotemporal resolution currently used to study chromatin biology.
Information-theoretic secure communications via caching. This project aims to address the cybersecurity problem of securing telecommunication networks to prevent data leakage. Current widely-adopted data-encryption approaches to secure communications will be broken with large-scale quantum computers, and existing information-theoretic approaches rely on the channel quality of the network. To circumvent these risks, this project proposes a new information security approach using information cache ....Information-theoretic secure communications via caching. This project aims to address the cybersecurity problem of securing telecommunication networks to prevent data leakage. Current widely-adopted data-encryption approaches to secure communications will be broken with large-scale quantum computers, and existing information-theoretic approaches rely on the channel quality of the network. To circumvent these risks, this project proposes a new information security approach using information cached at devices to camouflage data. The project will future-proof secure communication systems against large-scale quantum computers, which threaten current encryption approaches. This should ensure that data transmitted over communication networks can never be revealed to interceptors or hackers, even in public WiFi.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190101418
Funder
Australian Research Council
Funding Amount
$398,000.00
Summary
Extremely-high-speed and reliable coding for next generation communications. This project aims to develop fundamental coding theories and innovative coded-modulation techniques for the next generation backbone communication systems. The development of these techniques is expected to lead to dramatic increases of spectrum efficiency, data rate and reliability of communication systems. The techniques will enable extremely high speed and extremely reliable front-haul/back-haul communications, which ....Extremely-high-speed and reliable coding for next generation communications. This project aims to develop fundamental coding theories and innovative coded-modulation techniques for the next generation backbone communication systems. The development of these techniques is expected to lead to dramatic increases of spectrum efficiency, data rate and reliability of communication systems. The techniques will enable extremely high speed and extremely reliable front-haul/back-haul communications, which constitute the major building blocks of critical information and communications technology infrastructures for future digital society. This project is expected to support the sustainable development of the emerging digital society and new data-intensive applications, which are crucial for the long term economic growth for the Australian community.Read moreRead less
Enhancing Internet of Everything content acquisition, distribution, and security using software defined networking. The aim of this project is to develop novel frameworks and algorithms that improve video streaming experience across multiple interconnected content distribution networks. The novelty of the scheme is in optimally coupling cache server selection with network path control using software defined networking technology. The intended outcomes of this project are the development and demo ....Enhancing Internet of Everything content acquisition, distribution, and security using software defined networking. The aim of this project is to develop novel frameworks and algorithms that improve video streaming experience across multiple interconnected content distribution networks. The novelty of the scheme is in optimally coupling cache server selection with network path control using software defined networking technology. The intended outcomes of this project are the development and demonstration of algorithms and mechanisms for efficient Internet content delivery to achieve unprecedented user experience. The proposed project is expected to lead to commercial outcomes with consequent economic and social benefits, while strengthening Australia’s leadership in the emerging area of software defined networking.Read moreRead less
Cloud Security: Techniques for Securing Cloud Data and Services. Fundamental challenges in security and trust arise in cloud data storage and service provision. This project will achieve conceptual advances by proposing new security and trust models to secure cloud data and services. It will develop novel techniques to achieve efficient and secure cloud data management, propose new access control schemes for cloud services and develop new mechanisms for detecting sophisticated cyber threats. Thi ....Cloud Security: Techniques for Securing Cloud Data and Services. Fundamental challenges in security and trust arise in cloud data storage and service provision. This project will achieve conceptual advances by proposing new security and trust models to secure cloud data and services. It will develop novel techniques to achieve efficient and secure cloud data management, propose new access control schemes for cloud services and develop new mechanisms for detecting sophisticated cyber threats. This project will also propose a novel integrated trust enhanced cloud security architecture, enabling the design of adaptive secure systems which will be more resilient to dynamic cyber security attacks. It will demonstrate the proposed models and architecture using a practical cloud based online application.Read moreRead less
New high-performance iterative error correction codes. This project develops new error correction codes to underpin the success of next-generation communications technologies. The nature of the project presents significant potential for project outcomes to be beneficial to the Australian telecommunications industry in a wide range of application areas from optical communication to digital broadcasting.