This project will improve our understanding of how painkiller medicines work in very old and frail people which will improve the use of these medicines in pain management. This study will carefully examine pain control with two of the most commonly used pain killer medicines - paracetamol and oxycodone. By understanding all the factors that influence an older persons pain control we will be able to improve the safe and effective use of painkiller medicines in this special group of people.
Effects Of Ageing On Hepatic Drug Clearance And Mechanisms Of Drug Induced Liver Disease
Funder
National Health and Medical Research Council
Funding Amount
$581,892.00
Summary
With increasing age, there is increase in disease, for which medications may provide benefit, and an increase in the risk of adverse drug reactions, even after considering the increase in medication use by older people. We will investigate how the liver clears drugs from the blood in old age. This will guide dosing of medications for older people. We will also study how drugs injure the liver in old age and test interventions to prevent this toxicity.
Policy Translation Of An Australian Evaluation Of Computed Tomography (CT) Scanning
Funder
National Health and Medical Research Council
Funding Amount
$398,295.00
Summary
Our study will inform the national health care policy debate with respect to the future role of CT scanning in the health system, and provide the information needed to launch the dialogue among expert clinicians and technicians necessary for practitioner consensus in the appropriate methods for use of CT scanning. This study will use routinely collected administrative health data and data collected from CT scan providers in WA to evaluate the use of CT scanning in the Australian health system.