Optimisation of a novel hybrid vaccine for liver fluke disease in cattle. Optimisation of a novel hybrid vaccine for liver fluke disease in cattle. This project aims to optimise the formulation of novel fluke vaccine antigens by constructing combination hybrid recombinant antigens and using a protein adjuvant to improve immunogenicity, and test new antigens expressed in young flukes as vaccines and evaluate their ability to synergise with hybrid vaccines. Fasciola (fluke) infections cause seriou ....Optimisation of a novel hybrid vaccine for liver fluke disease in cattle. Optimisation of a novel hybrid vaccine for liver fluke disease in cattle. This project aims to optimise the formulation of novel fluke vaccine antigens by constructing combination hybrid recombinant antigens and using a protein adjuvant to improve immunogenicity, and test new antigens expressed in young flukes as vaccines and evaluate their ability to synergise with hybrid vaccines. Fasciola (fluke) infections cause serious economic losses to livestock production and fluke drug resistance threatens control, so new therapies such as a vaccine are needed. These vaccines should be evaluated in cattle trials. The major outcome plan is validation of hybrid antigens for commercial vaccine development for fluke control in cattle, leading to more sustainable beef and milk production in Australia.Read moreRead less
Topical and cryoanaesthesia for livestock husbandry. The livestock industries contribute $15billion annually to Australia's economy, playing a vital role in rural communities. However we must respond to changing demands of our customers, by complementing our competitive disease-free advantage with welfare-conscious production systems. This project will address the threat of growing international demands for improved animal welfare in farming. We will provide research and technical solutions, pro ....Topical and cryoanaesthesia for livestock husbandry. The livestock industries contribute $15billion annually to Australia's economy, playing a vital role in rural communities. However we must respond to changing demands of our customers, by complementing our competitive disease-free advantage with welfare-conscious production systems. This project will address the threat of growing international demands for improved animal welfare in farming. We will provide research and technical solutions, providing pain mangement products for on-farm use that will reduce animal suffering during routine husbandry interventions. The project offers significant benefits for producers by protecting their industries against the threats of a welfare embargo on our livestock products. Read moreRead less
Development of a novel vaccine targeting parasite tegument proteins for liver fluke disease in livestock. Liver fluke parasites cause serious economic losses for livestock producers in South-East Australia, but drug resistance threatens parasite control and economic productivity in rural communities. This project will use novel technologies to identify lead vaccine candidates for improved fluke control to sustain agricultural productivity.
Identification of causal variants for complex traits. The aim of this project is to identify causal variants for complex traits in cattle and humans. Although most important traits in agriculture, medicine and evolution are complex traits, very few of the genetic variants affecting these traits are known and this undermines our understanding of how genetic variants affect a trait and practical uses of this knowledge. Huge datasets of individuals with genome sequence and phenotypes and new statis ....Identification of causal variants for complex traits. The aim of this project is to identify causal variants for complex traits in cattle and humans. Although most important traits in agriculture, medicine and evolution are complex traits, very few of the genetic variants affecting these traits are known and this undermines our understanding of how genetic variants affect a trait and practical uses of this knowledge. Huge datasets of individuals with genome sequence and phenotypes and new statistical methods provide the opportunity to close this gap. The outcome will be identification of many genomic variants causing variation in complex traits. This will benefit scientific understanding of complex traits and the ability to predict traits for individuals from their genome sequence.Read moreRead less
Cracking the code of snails to elucidate parasite disease transmission. In Australia, a disease caused by liver flukes causes major economic losses to livestock production. The role of Australian pond snails as intermediate hosts for this parasite is poorly understood. This project aims to explore the phylogeography, biology and genomics of these snails. It expects to create novel molecular resources for important snail species and verify their roles as key vectors of flatworm parasites. The cur ....Cracking the code of snails to elucidate parasite disease transmission. In Australia, a disease caused by liver flukes causes major economic losses to livestock production. The role of Australian pond snails as intermediate hosts for this parasite is poorly understood. This project aims to explore the phylogeography, biology and genomics of these snails. It expects to create novel molecular resources for important snail species and verify their roles as key vectors of flatworm parasites. The curation of genomic and transcriptomic data sets, and elucidation of snail–parasite interactions will underpin the development of environmental diagnostic tests and deliver a new generation of intervention strategies to reduce the burden of liver fluke disease through the control of their snail intermediate hosts.Read moreRead less
Novel, Cost-Effective Methods for Measuring Methane Emissions from Grazing Livestock. Agriculture is second only to energy generation as a source of greenhouse gas emissions in Australia. Methane from cattle and sheep constitute 60% of these agricultural emissions. Their abatement is a win-win goal for the agricultural industry, reducing greenhouse emissions while increasing food efficiency. This project will develop a novel, cost- and-labour efficient method for on-farm measurements of the emis ....Novel, Cost-Effective Methods for Measuring Methane Emissions from Grazing Livestock. Agriculture is second only to energy generation as a source of greenhouse gas emissions in Australia. Methane from cattle and sheep constitute 60% of these agricultural emissions. Their abatement is a win-win goal for the agricultural industry, reducing greenhouse emissions while increasing food efficiency. This project will develop a novel, cost- and-labour efficient method for on-farm measurements of the emissions of methane from free-grazing cattle and sheep in their undisturbed environment. The method will be used to assess the dependence of methane emissions on factors such as diet and the efficacy of proposed methods for abatement of methane emissions, as well as providing improved data to the National Greenhouse Gas Inventory.Read moreRead less
Understanding the structure-function relationship of dietary fibre for engineering novel food products with superior textural properties and nutrition. The focus of this project will be on the merits of dietary fibre from underutilised agricultural by-products as valuable ingredients in food products. This project aims to innovate by developing high quality foods using dietary fibre, hence delivering socioeconomic benefits through a healthier population and increased financial returns to agri-fo ....Understanding the structure-function relationship of dietary fibre for engineering novel food products with superior textural properties and nutrition. The focus of this project will be on the merits of dietary fibre from underutilised agricultural by-products as valuable ingredients in food products. This project aims to innovate by developing high quality foods using dietary fibre, hence delivering socioeconomic benefits through a healthier population and increased financial returns to agri-food processors.Read moreRead less
Incorporation of legume protein in liquid breakfast for a healthy Australia. This project aims to understand and control the properties and interactions of legume protein with other ingredients (e.g. whey protein and dietary fibre) to formulate healthy liquid foods with superior techno-functionality. This research should significantly broaden our understanding of the behaviour of legume protein-phospholipid complexes and their contribution to malodorous flavour development. The expected outcomes ....Incorporation of legume protein in liquid breakfast for a healthy Australia. This project aims to understand and control the properties and interactions of legume protein with other ingredients (e.g. whey protein and dietary fibre) to formulate healthy liquid foods with superior techno-functionality. This research should significantly broaden our understanding of the behaviour of legume protein-phospholipid complexes and their contribution to malodorous flavour development. The expected outcomes are protocols to prevent undesirable sensory characteristics in liquid foods. This should benefit the food industry by improving the sensory attributes of beverages enriched with legume protein, leading to the creation of novel, highly nutritious products with superior sensory attributes and long shelf-life.Read moreRead less
Intelligent bioprocessing for next-generation nutritional yeast extracts. This project aims to provide new, science-based levers for optimising the industrial production of tailormade yeast extracts for food applications. Advanced biochemical and engineering methods will be used to develop new knowledge of the links between yeast growth conditions, cell biochemistry, processing and the flavour and texture profiles of yeast hydrolysates. This understanding will allow the properties of yeast hydro ....Intelligent bioprocessing for next-generation nutritional yeast extracts. This project aims to provide new, science-based levers for optimising the industrial production of tailormade yeast extracts for food applications. Advanced biochemical and engineering methods will be used to develop new knowledge of the links between yeast growth conditions, cell biochemistry, processing and the flavour and texture profiles of yeast hydrolysates. This understanding will allow the properties of yeast hydrolysates to be accurately tuned during yeast production and processing. The resulting process improvements and innovations will increase the efficiency and quality of current yeast extract products and allow the development of new food products.Read moreRead less