ASTROID: Active Surveillance And Other TReatment OptIons For Prostate Cancer. A Randomised Controlled Trial Of Decision Aid And DVD Information Support For Men Diagnosed With Low-risk Prostate Cancer And Their Partners
Funder
National Health and Medical Research Council
Funding Amount
$782,369.00
Summary
This summary was provided in the grant application.
How Can We Accurately Predict Intra-cranial Injury In Children: The APIC Study
Funder
National Health and Medical Research Council
Funding Amount
$836,500.00
Summary
Head injuries are a common in children. Even a seemingly minor incident may cause serious brain injury. Whilst head computed tomography (CT) identifies all important injuries there is a growing recognition that radiation from CTs increases the risk of fatal brain cancers, especially in younger children. This study of 10,000 children with head injuries aims to investigate the best way to accurately predict which children should undergo a head CT, and which children do not require one.
The CRISP Trial: An RCT Of Risk Assessment And Decision Support To Implement Risk-stratified Colorectal Cancer Screening In Primary Care.
Funder
National Health and Medical Research Council
Funding Amount
$936,641.00
Summary
There is a mismatch between people’s use of bowel cancer screening tests through faecal occult blood testing or colonoscopy and their individual risk of bowel cancer. Building on the work of our NHMRC Centre for Research Excellence (CRE) on Optimising Colorectal Cancer Screening, this trial will test the effect of an electronic risk assessment tool, implemented in general practice, on use of the most appropriate screening test for bowel cancer based on a person’s risk of developing the condition
Improving Global Tuberculosis Control With The AuTuMN Platform
Funder
National Health and Medical Research Council
Funding Amount
$655,059.00
Summary
Tuberculosis (TB) is the world’s leading infectious killer, with the failure of global control responsible for the vast majority of Australia’s cases. Using our robustly developed software platform, we have performed several country-level studies to predict the future burden of disease and compare the impact of alternative responses to controlling the epidemic. In this project, we will extend our platform to perform simulations at the global level and answer key questions in TB control.
Improving Communication Outcomes For Migrant Cancer Patients
Funder
National Health and Medical Research Council
Funding Amount
$609,493.00
Summary
INFORM is a research project designed to improve services available for Culturally and Linguistically Diverse (CALD) cancer patients. To achieve this, we are developing a communication aid intervention, which involves audio-recording key patient hospital consultations and Question Prompt List (QPL). The purpose of this communication aid package will be to improve patient health information knowledge, and communication with their healthcare team.
Towards Adequate National Provision Of Genomic Testing In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$515,493.00
Summary
Genomic information about unborn children can now be provided using chromosomal microarrays which have the potential to revolutionize maternal care in Australia, but are currently only used in high risk pregnancies. Soon all pregnant women, the vast majority who currently have prenatal screening, will be able to access this and other genomic technologies. We will examine the psychological impact of fetal genomic testing and, in doing so, assess the need for service planning, as well as potential ....Genomic information about unborn children can now be provided using chromosomal microarrays which have the potential to revolutionize maternal care in Australia, but are currently only used in high risk pregnancies. Soon all pregnant women, the vast majority who currently have prenatal screening, will be able to access this and other genomic technologies. We will examine the psychological impact of fetal genomic testing and, in doing so, assess the need for service planning, as well as potential legal and policy changes in Australia.Read moreRead less
Asking The Right Questions About Attention-deficit Hyperactivity Disorder In Children: A Cluster Randomized Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$484,930.00
Summary
This study will evaluate the impact of a novel question prompt list (QPL) for parents of children with attention-deficit hyperactivity disorder (ADHD), on their communication with their child’s doctor, and health outcomes such as adherence. The QPL aims to increase parent question asking and information sharing between clinicians and parents; improve parents’ ADHD knowledge across the developmental lifespan of their child; and thus improve adherence to medication in children with ADHD.
Informing Women About Over-diagnosis In Mammography Screening: A Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$441,666.00
Summary
Overdiagnosis (detection of inconsequential disease) is a serious and important harm of breast cancer screening. Women have little or no knowledge of it and there is no evidence about how information on overdiagnosis affects women’s views about breast cancer and screening. This study will examine how women respond to evidence-based information about overdiagnosis in breast screening, in terms of their screening decisions, attitudes and understanding, and other relevant aspects of their experienc ....Overdiagnosis (detection of inconsequential disease) is a serious and important harm of breast cancer screening. Women have little or no knowledge of it and there is no evidence about how information on overdiagnosis affects women’s views about breast cancer and screening. This study will examine how women respond to evidence-based information about overdiagnosis in breast screening, in terms of their screening decisions, attitudes and understanding, and other relevant aspects of their experience.Read moreRead less
IPrevent: Development And Pilot Testing Of An Evidence-based, Tailored, Computerised Risk Assessment And Decision Support Tool To Facilitate Discussions About Breast Cancer Prevention And Screening Measures.
Funder
National Health and Medical Research Council
Funding Amount
$415,143.00
Summary
Women at increased risk for breast cancer should be identified and offered prevention and intensified screening. Yet most women don’t know their personal risk for breast cancer. We will develop a user friendly, computerised tool which, used with her doctor, will help each woman understand her personal breast cancer risk and the benefits and disadvantages of prevention and screening strategies. It will empower women to understand and take control of their breast cancer risk.
Optimization Of Splice Switching Therapies To Treat Duchenne Muscular Dystrophy
Funder
National Health and Medical Research Council
Funding Amount
$448,827.00
Summary
Duchenne muscular dystrophy, the most common and serious form of childhood muscle wasting, is caused by mutations in the dystrophin gene that block synthesis of the normal product. Antisense oligomers have been used in clinical trials to remove the disease-causing part of the message and rescue expression. Clinical trials have demonstrated proof-of-concept, although individual responses varied. This application seeks to improve the therapeutic potential of these compounds.